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Gene · 5932

RBBP8: RB binding protein 8, endonuclease

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RBBP8: RB binding protein 8, endonuclease. Genes, record 5932. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5932

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Gene

Symbol
RBBP8
HGNC
Name
RB binding protein 8, endonuclease
HGNC
NCBI Gene ID
5932
NCBI Gene
HGNC ID
HGNC:9891
HGNC
Ensembl
ENSG00000101773
NCBI Gene
Aliases
COM1, CTIP, CtIP, JAWAD, JWDS, RIM, SAE2, SCKL2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99708DNA endonuclease RBBP88974Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4827902 A12026-10-2810Q99708Espacenet
EP 4650780 A22025-11-195469Q99708Espacenet
EP 4641201 A22025-10-295081Q99708Espacenet
EP 4641202 A22025-10-294967Q99708Espacenet
JP 2025100656 A2025-07-0316Q99708Espacenet
JP 2025517969 A2025-06-125081Q99708Espacenet
JP 2025517970 A2025-06-125469Q99708Espacenet
KR 1020250017231 A2025-02-044967Q99708Espacenet
WO 2025006963 A12025-01-0237Q99708Espacenet
EP 4464338 A22024-11-20166Q99708Espacenet

1 to 10 of 60

See all 60 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,983

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRBBP8 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines552025
P30CA008748Cancer Center Support Grant332025
P30CA016672Cancer Center Support Grant252025
ZIABC010959Relationship between DNA damage detection and signaling142025
ZIABC010283DNA repair132025
P30CA006927Comprehensive Cancer Center Program at Fox Chase122025
P30CA033572Cancer Center Support Grant122025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability122025
P30CA016086Cancer Center Support Grant112025
R01CA198279Shaping DNA Damage Response Networks Via Histone H2A Variants112025

1 to 10 of 1,983Source NIH's project files

See all 1,983 nih grants

Papers3,043

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The BRCA1-A complex: At the edge of resection and the beauty of restraint.DNA Repair (Amst)202642826492PubTator, text miningPubMed
Structural and thermodynamic analysis of BRCA1 BRCT variants identified in Middle Eastern breast cancer cohorts.Protein Pept Lett202642692369PubTator, text miningPubMed
The tumor suppressor menin is a key scaffold mediator for homologous recombination repair.Nucleic Acids Res202642578372PubTator, text miningPubMed
NEK3 promotes cancer resistance through facilitating CtIP-mediated DNA repair.DNA Repair (Amst)202642497526PubTator, text miningPubMed
Cell-cycle-dependent regulation of DNA end resection by PLK1 and PLK3 without CtIP level modulation.iScience202642436985PubTator, text miningPubMed
Pemphigoid gestationis and anti-SAE2-positive inflammatory myopathy without cutaneous involvement following assisted reproductive technology pregnancy: a rare autoimmune association.Ital J Dermatol Venerol202642411699PubTator, text miningPubMed
Integrating Machine Learning and Structure-Guided Discovery of a Novel Type II SYK Inhibitor for Treating Triple-Negative Breast Cancer.J Med Chem202642304805PubTator, text miningPubMed
SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy.Sci Adv202642284420PubTator, text miningPubMed
An integrative mutational and network analysis of pancreatic cancer reveals key genes, and signalling pathways.Funct Integr Genomics202642277390PubTator, text miningPubMed
Construction of a novel signature based on CRISPR-Cas9 screening for prognostic prediction in breast cancer.BMC Cancer202642135732PubTator, text miningPubMed

1 to 10 of 3,043

See all 3,043 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5932

GET https://conductscience.org/api/genes/v1/5932/patents?page=2