ConductScience.org, home

Gene · 59340

HRH4: histamine receptor H4

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. HRH4: histamine receptor H4. Genes, record 59340. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/59340

On this page

Gene

Symbol
HRH4
HGNC
Name
histamine receptor H4
HGNC
NCBI Gene ID
59340
NCBI Gene
HGNC ID
HGNC:17383
HGNC
Ensembl
ENSG00000134489
NCBI Gene
Aliases
AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H3N8Histamine H4 receptor39015Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449120Q9H3N8Espacenet
JP 2025529142 A2025-09-041985Q9H3N8Espacenet
US 12371689 B22025-07-291985Q9H3N8Espacenet
US 11446398 B22022-09-2038379Q9H3N8Espacenet
US 11400116 B22022-08-024810Q9H3N8Espacenet
JP 2022524081 A2022-04-27141350Q9H3N8Espacenet
US 10772934 B22020-09-151129Q9H3N8Espacenet
EP 3504344 A12019-07-031478Q9H3N8Espacenet
US 10292374 B22019-05-21598Q9H3N8Espacenet
JP 2019054813 A2019-04-11229555Q9H3N8Espacenet

1 to 10 of 61

See all 61 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADRIFORANTCHEMBL1915540Histamine H4 receptor antagonistANTAGONISTChEMBL
TOREFORANTCHEMBL3301609Histamine H4 receptor antagonistANTAGONISTChEMBL
UR-63325CHEMBL5314396Histamine H4 receptor antagonistANTAGONISTChEMBL

Trials10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03948334ADRIFORANTPHASE22021-07-20ClinicalTrials.gov
NCT03517566ADRIFORANTPHASE22021-07-20ClinicalTrials.gov
NCT02618616ADRIFORANTPHASE22021-07-20ClinicalTrials.gov
NCT02424253ADRIFORANTPHASE22021-05-13ClinicalTrials.gov
NCT01823016TOREFORANTPHASE2ClinicalTrials.gov
NCT01679951TOREFORANTPHASE2ClinicalTrials.gov
NCT01450982TOREFORANTPHASE1ClinicalTrials.gov
NCT01260753UR-63325PHASE2ClinicalTrials.gov
NCT00941707TOREFORANTPHASE2ClinicalTrials.gov
NCT00856687ADRIFORANTPHASE1ClinicalTrials.gov

NIH grants468

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHRH4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant22025
P30CA013148Comprehensive Cancer Center Support Grant22025
P30DK056338Texas Medical Center Digestive Diseases Center22025
P30DK123704MUSC Digestive Disease Research Core Center22025
P50CA097257Brain Tumor SPORE Grant22025
P50CA127001SPORE in Brain Cancer22025
R01CA120813Modulation of Microglia and T Cell Interactions in Malignant Glioma22025
T32AI083216Northwestern University Allergy and Immunology Research (NUAIR) Program22025
T32DK007664Research Training in Pediatrics Gastroenterolgy22025
U19AG063893The Long Life Family Study22025

1 to 10 of 468Source NIH's project files

See all 468 nih grants

Papers1,168

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TRPV4 promotes histamine receptor signaling in lymphatic endothelial cells.Cell Calcium202642664800PubTator, text miningPubMed
Virtual Screening, Synthesis and In Vitro Characterization of Histamine H4 Receptor Ligands Based on Pyrimidine Scaffolds.Int J Mol Sci202642589546PubTator, text miningPubMed
A subset of histamine H4 receptor antagonists prevents B lymphocyte proliferation induced by BCR/TLR9 engagement or EBV infection.Antiviral Res202642140525PubTator, text miningPubMed
Histamine H4 receptor in neuroinflammation: Dual roles in multiple sclerosis and Parkinson's disease.Neurobiol Dis202641997459PubTator, text miningPubMed
Quantitative deciphering of mammalian histamine receptors through mathematical genomics.Biochem Biophys Res Commun202641946080PubTator, text miningPubMed
A Potential Central Hub of Histamine in the Microbiota-Gut-Joint Axis in Rheumatoid Arthritis: Mechanisms and Translational Implications.Int J Mol Sci202641828539PubTator, text miningPubMed
Differential conservation analysis identifies residues defining constitutive internalization in beta-adrenergic receptors.iScience202641797919PubTator, text miningPubMed
Computational approaches for the identification of potential HDAC2 inhibitors and histamine H3 receptor antagonists from Berberis vulgaris: a dual mechanistic approach for autism spectrum disorder treatment.
Open Life Sci202641737604PubTator, text miningPubMed
Deciphering the air pollution-osteoarthritis relationship: insights from network toxicology, integrated machine learning, and molecular docking.Environ Geochem Health202641718809PubTator, text miningPubMed
Cystamine is a redox-dependent inverse agonist of the histamine H4 receptor.Am J Physiol Cell Physiol202641481277PubTator, text miningPubMed

1 to 10 of 1,168

See all 1,168 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/59340

GET https://conductscience.org/api/genes/v1/59340/patents?page=2