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Gene · 59341

TRPV4: transient receptor potential cation channel subfamily V member 4

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. TRPV4: transient receptor potential cation channel subfamily V member 4. Genes, record 59341. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/59341

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
TRPV4
HGNC
Name
transient receptor potential cation channel subfamily V member 4
HGNC
NCBI Gene ID
59341
NCBI Gene
HGNC ID
HGNC:18083
HGNC
Ensembl
ENSG00000111199
NCBI Gene
Aliases
BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VR-OAC, VRL-2, VRL2, VROAC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HBA0Transient receptor potential cation channel subfamily V member 487119Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467663Q9HBA0Espacenet
JP 2026004568 A2026-01-1467666Q9HBA0Espacenet
EP 4641201 A22025-10-291532Q9HBA0Espacenet
JP 2025529142 A2025-09-045079Q9HBA0Espacenet
US 12371689 B22025-07-295079Q9HBA0Espacenet
JP 2025517969 A2025-06-121532Q9HBA0Espacenet
US 11446398 B22022-09-2090392Q9HBA0Espacenet
US 11446398 B22022-09-2090393Q9HBA0Espacenet
US 11400116 B22022-08-024811Q9HBA0Espacenet
JP 2022524081 A2022-04-27193363Q9HBA0Espacenet

1 to 10 of 38

See all 38 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BUTAMBENCHEMBL127516Transient receptor potential cation channel subfamily V member 4 inhibitorINHIBITORChEMBL
BUTAMBEN PICRATECHEMBL3142541Transient receptor potential cation channel subfamily V member 4 inhibitorINHIBITORChEMBL
GSK2798745CHEMBL4470585Transient receptor potential cation channel subfamily V member 4 antagonistANTAGONISTChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04292912GSK2798745PHASE12024-11-08ClinicalTrials.gov
NCT03511105GSK2798745PHASE12020-02-05ClinicalTrials.gov
NCT02497937GSK2798745PHASE22018-09-05ClinicalTrials.gov

NIH grants2,343

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30EY014800University of Utah Core Vision Research Grant292025
R01EY027920Molecular mechanisms of mechanotransduction in the aqueous outflow pathway242025
T32EY024234Vision Research Training Grant at the University of Utah182025
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center132025
P30AR074992RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE122025
R01HL142808Paracrine TNF signaling impairs endothelial TRPV4 microdomains in obesity112025
R01HL146914Flow-Activated Calcium Signaling Microdomains in Small Pulmonary Arteries102025
R01GM093290Regulation of the epithelial Ca2+ channels TRPV6 and TRPV582025
R01NS070711Nociceptive Mechanisms Underlying Sickle Cell Pain82025
R35NS122306Translating Pathomechanisms into Treatment for Spinal Muscular Atrophies82025

1 to 10 of 2,343Source NIH's project files

See all 2,343 nih grants

Papers4,540

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42808736PubTator, text miningPubMed
42794733PubTator, text miningPubMed
42794478PubTator, text miningPubMed
42782815PubTator, text miningPubMed
42779518PubTator, text miningPubMed
42750211PubTator, text miningPubMed
42749621PubTator, text miningPubMed
42747764PubTator, text miningPubMed
42744885PubTator, text miningPubMed
42737595PubTator, text miningPubMed

1 to 10 of 4,540

See all 4,540 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/59341

GET https://conductscience.org/api/genes/v1/59341/patents?page=2