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BCL2: BCL2 apoptosis regulator

1 protein, 223 patents, 7 drugs, 848 trials, 26,096 NIH grants and 145,102 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolBCL2HGNC
NameBCL2 apoptosis regulatorHGNC
NCBI Gene ID596NCBI Gene
HGNC IDHGNC:990HGNC
EnsemblENSG00000171791NCBI Gene
AliasesBcl-2, PPP1R50NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P10415Apoptosis regulator Bcl-223963Ensembl, GeneID, HGNCUniProt

Patents 223

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4825362 A12026-10-2148P10415Espacenet
EP 4803075 A12026-09-0948P10415Espacenet
WO 2026013153 A12026-01-151P10415Espacenet
WO 2025229052 A12025-11-063P10415Espacenet
EP 4641201 A22025-10-295523P10415Espacenet
JP 2025147176 A2025-10-0616521P10415Espacenet
US 12419913 B22025-09-23242P10415Espacenet
WO 2025132801 A12025-06-261P10415Espacenet
JP 2025517969 A2025-06-125523P10415Espacenet
US 12287338 B22025-04-291P10415Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APG-2575CHEMBL4650374Apoptosis regulator Bcl-2 inhibitorINHIBITORChEMBL
NAVITOCLAXCHEMBL443684Apoptosis regulator Bcl-2 inhibitorINHIBITORChEMBL
OBATOCLAXCHEMBL408194Apoptosis regulator Bcl-2 inhibitorINHIBITORChEMBL
OBATOCLAX MESYLATECHEMBL2107358Apoptosis regulator Bcl-2 inhibitorINHIBITORChEMBL
OBLIMERSENCHEMBL2108324Bcl-2 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
OBLIMERSEN SODIUMCHEMBL2109229Bcl-2 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
VENETOCLAXCHEMBL3137309Apoptosis regulator Bcl-2 inhibitorINHIBITORChEMBL

Trials 848

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605949VENETOCLAXPHASE2ClinicalTrials.gov
NCT07604233VENETOCLAXPHASE1/PHASE2ClinicalTrials.gov
NCT07601607APG-2575PHASE1/PHASE2ClinicalTrials.gov
NCT07583888VENETOCLAXPHASE2/PHASE3ClinicalTrials.gov
NCT07582159VENETOCLAXPHASE2ClinicalTrials.gov
NCT07581002VENETOCLAXPHASE2/PHASE3ClinicalTrials.gov
NCT07572695VENETOCLAXClinicalTrials.gov
NCT07563179VENETOCLAXPHASE2ClinicalTrials.gov
NCT07557056VENETOCLAXPHASE2ClinicalTrials.gov
NCT07552324APG-2575PHASE2ClinicalTrials.gov

NIH grants 26096

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant8512,025NIH's project files
P30CA008748Cancer Center Support Grant4072,025NIH's project files
P30CA016058Cancer Center Support Grant1582,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)1212,025NIH's project files
P30CA006973Regional Oncology Research Center1162,025NIH's project files
P30CA047904Cancer Center Support Grant1082,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant982,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant922,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant862,025NIH's project files
P30CA033572Cancer Center Support Grant812,025NIH's project files

Papers 145102

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827144PubTator, text miningPubMed
42826809PubTator, text miningPubMed
42826661PubTator, text miningPubMed
42825974PubTator, text miningPubMed
42824816PubTator, text miningPubMed
42824338PubTator, text miningPubMed
42824020PubTator, text miningPubMed
42823178PubTator, text miningPubMed
42822579PubTator, text miningPubMed
42820997PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license