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REN: renin

1 protein, 37 patents, 5 drugs, 113 trials, 12,867 NIH grants and 87,037 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRENHGNC
NamereninHGNC
NCBI Gene ID5972NCBI Gene
HGNC IDHGNC:9958HGNC
EnsemblENSG00000143839NCBI Gene
AliasesADTKD4, HNFJ2, RTDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00797Renin40691Ensembl, GeneID, HGNCUniProt

Patents 37

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461372P00797Espacenet
EP 4650780 A22025-11-192802P00797Espacenet
JP 2025147176 A2025-10-0611320P00797Espacenet
JP 2025529142 A2025-09-047549P00797Espacenet
US 12371689 B22025-07-297549P00797Espacenet
JP 2025517970 A2025-06-122802P00797Espacenet
JP 2025028160 A2025-02-2811320P00797Espacenet
KR 1020250010750 A2025-01-2111320P00797Espacenet
JP 2024109657 A2024-08-1411327P00797Espacenet
US 11446398 B22022-09-2072586P00797Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALISKIRENCHEMBL1639Renin inhibitorINHIBITORChEMBL
ALISKIREN FUMARATECHEMBL3545059Renin inhibitorINHIBITORChEMBL
IMARIKIRENCHEMBL3990145Renin inhibitorINHIBITORChEMBL
IMARIKIREN HYDROCHLORIDECHEMBL3969876Renin inhibitorINHIBITORChEMBL
SITOKIRENCHEMBL4110551Renin inhibitorINHIBITORChEMBL

Trials 113

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05770609SITOKIRENPHASE2ClinicalTrials.gov
NCT05593575SITOKIRENPHASE2ClinicalTrials.gov
NCT05359068SITOKIRENPHASE3ClinicalTrials.gov
NCT05019742SITOKIRENPHASE22025-06-26ClinicalTrials.gov
NCT04183101ALISKIRENPHASE2ClinicalTrials.gov
NCT03756103SITOKIRENPHASE2ClinicalTrials.gov
NCT02446548ALISKIRENClinicalTrials.gov
NCT02332824IMARIKIREN HYDROCHLORIDEPHASE22018-08-13ClinicalTrials.gov
NCT01922141ALISKIRENPHASE4ClinicalTrials.gov
NCT01715207ALISKIRENPHASE32017-05-04ClinicalTrials.gov

NIH grants 12867

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
UL1TR001863Yale Clinical and Translational Science Award842,025NIH's project files
U54GM115428Mississippi Center for Clinical and Translational Research592,025NIH's project files
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 2442,025NIH's project files
U01DK060902Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center352,025NIH's project files
T32HL007457Mechanisms of Hypertension and Cardiovascular Diseases342,025NIH's project files
P50DK096373Regulation of Cell Fate during Kidney Development and Disease332,025NIH's project files
ZIAHL006001Framingham Project/Levy332,025NIH's project files
T32HL105324Hypertension and Cardiorenal Research Training Program322,025NIH's project files
U01DK060984Prospective renal insufficiency cohort evaluation: PRICE322,025NIH's project files
U54GM104940Louisiana Clinical and Translational Science Center322,025NIH's project files

Papers 87037

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827265PubTator, text miningPubMed
42826581PubTator, text miningPubMed
42826060PubTator, text miningPubMed
42824686PubTator, text miningPubMed
42824143PubTator, text miningPubMed
42823719PubTator, text miningPubMed
42820470PubTator, text miningPubMed
42820267PubTator, text miningPubMed
42819199PubTator, text miningPubMed
42817848PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license