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Gene · 5976

UPF1: UPF1 RNA helicase and ATPase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. UPF1: UPF1 RNA helicase and ATPase. Genes, record 5976. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5976

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Gene

Symbol
UPF1
HGNC
Name
UPF1 RNA helicase and ATPase
HGNC
NCBI Gene ID
5976
NCBI Gene
HGNC ID
HGNC:9962
HGNC
Ensembl
ENSG00000005007
NCBI Gene
Aliases
HUPF1, KIAA0221, NORF1, RENT1, UTF, pNORF1, smg-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92900Regulator of nonsense transcripts 11,12912Ensembl, GeneID, HGNC

Source UniProt

Patents10

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1917888Q92900Espacenet
EP 4641201 A22025-10-2922183Q92900Espacenet
JP 2025517969 A2025-06-1222183Q92900Espacenet
JP 2025517970 A2025-06-1217888Q92900Espacenet
US 11446398 B22022-09-2095821Q92900Espacenet
JP 2022524081 A2022-04-27198792Q92900Espacenet
KR 1020210045575 A2021-04-2747Q92900Espacenet
KR 1020210045236 A2021-04-2647Q92900Espacenet
WO 2020043864 A12020-03-052085Q92900Espacenet
WO 2017037279 A12017-03-0932Q92900Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,626

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUPF1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant132025
ZIAHL006158Mechanisms of nonsense-mediated mRNA decay target selection102025
P30CA016672Cancer Center Support Grant72025
R01HL128239Genetic and molecular basis for SRSF2 mutations in myelodysplasia62025
P30CA015704Cancer Center Support Grant52025
P30CA045508CSHL Cancer Center Support Grant52025
P40OD010440Caenorhabditis Genetics Center52025
P30CA010815Consolidated Basic Cancer Research Program42025
P30CA016087Cancer Center Support Grant42025
P30CA021765Cancer Center Support Grant (CCSG)42025

1 to 10 of 1,626Source NIH's project files

See all 1,626 nih grants

Papers2,361

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells.Life Sci Alliance202642716788PubTator, text miningPubMed
TDP-43 promotes allergen-induced inflammation and influenza A virus replication in airway epithelium.Nat Commun202642642428PubTator, text miningPubMed
Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer.Front Syst Biol202642630458PubTator, text miningPubMed
3'UTR-directed, kinase-proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells.iScience202642597915PubTator, text miningPubMed
Genome-Wide Impact of Human DBR1 Depletion on RNA Processing Networks Reveal a Connection Between Pre-mRNA Splicing, mRNA Surveillance and Stress Granule Dynamics.J Mol Biol202642551782PubTator, text miningPubMed
SMG1 in hepatocellular carcinoma: A context-dependent tumor suppressor and a targetable node for NMD-directed immunotherapy.Crit Rev Oncol Hematol202642537828PubTator, text miningPubMed
Global Changes in Unproductive Splicing and NMD Efficiency in Tumors.Acta Naturae202642499671PubTator, text miningPubMed
Correction: Regulation of oncogenic C-terminal truncated p53β protein isoform expression by SRSF3-UPF1 splicing and surveillance axis.Cell Biosci202642437955PubTator, text miningPubMed
Temporal Proteomic Characterization of SARS-CoV-2-Infected Mouse Lungs.Mol Cell Proteomics202642392362PubTator, text miningPubMed
UPF3A and UPF3B Shape the Transcriptome Cooperatively Yet Oppose Cell Function.J Mol Biol202642372941PubTator, text miningPubMed

1 to 10 of 2,361

See all 2,361 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5976

GET https://conductscience.org/api/genes/v1/5976/grants?page=2