Gene · 5976
UPF1: UPF1 RNA helicase and ATPase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. UPF1: UPF1 RNA helicase and ATPase. Genes, record 5976. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5976
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92900 | Regulator of nonsense transcripts 1 | 1,129 | 12 | Ensembl, GeneID, HGNC |
Source UniProt
Patents10
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 17888 | Q92900 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 22183 | Q92900 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 22183 | Q92900 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 17888 | Q92900 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 95821 | Q92900 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 198792 | Q92900 | Espacenet |
| KR 1020210045575 A | 2021-04-27 | 47 | Q92900 | Espacenet |
| KR 1020210045236 A | 2021-04-26 | 47 | Q92900 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 2085 | Q92900 | Espacenet |
| WO 2017037279 A1 | 2017-03-09 | 32 | Q92900 | Espacenet |
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,626
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | UPF1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| ZIAHL006158 | Mechanisms of nonsense-mediated mRNA decay target selection | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| R01HL128239 | Genetic and molecular basis for SRSF2 mutations in myelodysplasia | 6 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 5 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 5 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 5 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 4 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
1 to 10 of 1,626Source NIH's project files
See all 1,626 nih grantsPapers2,361
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells. | Life Sci Alliance | 2026 | 42716788 | PubTator, text mining | PubMed |
| TDP-43 promotes allergen-induced inflammation and influenza A virus replication in airway epithelium. | Nat Commun | 2026 | 42642428 | PubTator, text mining | PubMed |
| Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer. | Front Syst Biol | 2026 | 42630458 | PubTator, text mining | PubMed |
| 3'UTR-directed, kinase-proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells. | iScience | 2026 | 42597915 | PubTator, text mining | PubMed |
| Genome-Wide Impact of Human DBR1 Depletion on RNA Processing Networks Reveal a Connection Between Pre-mRNA Splicing, mRNA Surveillance and Stress Granule Dynamics. | J Mol Biol | 2026 | 42551782 | PubTator, text mining | PubMed |
| SMG1 in hepatocellular carcinoma: A context-dependent tumor suppressor and a targetable node for NMD-directed immunotherapy. | Crit Rev Oncol Hematol | 2026 | 42537828 | PubTator, text mining | PubMed |
| Global Changes in Unproductive Splicing and NMD Efficiency in Tumors. | Acta Naturae | 2026 | 42499671 | PubTator, text mining | PubMed |
| Correction: Regulation of oncogenic C-terminal truncated p53β protein isoform expression by SRSF3-UPF1 splicing and surveillance axis. | Cell Biosci | 2026 | 42437955 | PubTator, text mining | PubMed |
| Temporal Proteomic Characterization of SARS-CoV-2-Infected Mouse Lungs. | Mol Cell Proteomics | 2026 | 42392362 | PubTator, text mining | PubMed |
| UPF3A and UPF3B Shape the Transcriptome Cooperatively Yet Oppose Cell Function. | J Mol Biol | 2026 | 42372941 | PubTator, text mining | PubMed |
1 to 10 of 2,361
See all 2,361 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5976
GET https://conductscience.org/api/genes/v1/5976/grants?page=2