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RET: ret proto-oncogene

1 protein, 169 patents, 22 drugs, 1,500 trials, 13,531 NIH grants and 40,232 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRETHGNC
Nameret proto-oncogeneHGNC
NCBI Gene ID5979NCBI Gene
HGNC IDHGNC:9967HGNC
EnsemblENSG00000165731NCBI Gene
AliasesCDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07949Proto-oncogene tyrosine-protein kinase receptor Ret1,11434Ensembl, GeneID, HGNCUniProt

Patents 169

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4808922 A12026-09-232P07949Espacenet
JP 2026004568 A2026-01-1461413P07949Espacenet
EP 4640849 A22025-10-291061P07949Espacenet
EP 4641201 A22025-10-297133P07949Espacenet
JP 2025533979 A2025-10-092P07949Espacenet
JP 2025147176 A2025-10-0611339P07949Espacenet
JP 2025529142 A2025-09-043697P07949Espacenet
JP 2025529142 A2025-09-047552P07949Espacenet
JP 2025113406 A2025-08-01310P07949Espacenet
JP 2025525078 A2025-08-012P07949Espacenet

Drugs 22

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALECTINIBCHEMBL1738797Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
ALECTINIB HYDROCHLORIDECHEMBL3707320Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
AST-487CHEMBL574738Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
BOS-589CHEMBL4650296Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
CEP-2563CHEMBL6069183Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
CEP-32496CHEMBL2029988Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
LESTAURTINIBCHEMBL603469Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
MOTESANIBCHEMBL572881Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
PRALSETINIBCHEMBL4582651Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL

Trials 1500

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07573696ALECTINIBPHASE2ClinicalTrials.gov
NCT07572695SORAFENIBClinicalTrials.gov
NCT07560410ALECTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov
NCT07495579REGORAFENIBPHASE2ClinicalTrials.gov
NCT07478991QUIZARTINIBPHASE3ClinicalTrials.gov

NIH grants 13531

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant5482,025NIH's project files
P30CA016672Cancer Center Support Grant4592,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant972,025NIH's project files
P30CA016058Cancer Center Support Grant902,025NIH's project files
P30CA006973Regional Oncology Research Center742,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant672,025NIH's project files
P30CA068485Cancer Center Support Grant592,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)562,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award462,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase452,025NIH's project files

Papers 40232

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826913PubTator, text miningPubMed
42824982PubTator, text miningPubMed
42823821PubTator, text miningPubMed
42823154PubTator, text miningPubMed
42822756PubTator, text miningPubMed
42822599PubTator, text miningPubMed
42820254PubTator, text miningPubMed
42819803PubTator, text miningPubMed
42818202PubTator, text miningPubMed
42812292PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license