Gene · 5981
RFC1: replication factor C subunit 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RFC1: replication factor C subunit 1. Genes, record 5981. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5981
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P35251 | Replication factor C subunit 1 | 1,148 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 10840 | P35251 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10840 | P35251 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 363 | P35251 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8164 | P35251 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 363 | P35251 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 72595 | P35251 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 175566 | P35251 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 9511 | P35251 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 2090 | P35251 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 8164 | P35251 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,549
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RFC1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 35 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 16 | 2025 |
| R01GM050006 | Enzymology of Mismatch Repair in Yeast | 9 | 2025 |
| R35GM131754 | Structural mechanism of DNA replication | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| R01NS072248 | Genome Studies in Hereditary Spastic Paraplegia- Beyond the Exome | 7 | 2025 |
| R01GM058015 | Recombinational Mechanisms of DNA Repair | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 5 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 5 | 2025 |
1 to 10 of 1,549Source NIH's project files
See all 1,549 nih grantsPapers2,391
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Erratum for the Research Article "AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS neurons" by C. Maltby et al. | Sci Adv | 2026 | 42826216 | PubTator, text mining | PubMed |
| Lightweight CNN recognition of HeLa cell PCNA‑based S‑phase subphases and RFC‑dependent dynamics. | Acta Neurobiol Exp (Wars) | 2026 | 42808670 | PubTator, text mining | PubMed |
| Hereditary and Non-hereditary Cerebellar Ataxias in Latvia: Six Years of Experience at the National Reference Centre (ERN-RND Affiliated Partner). | Cerebellum | 2026 | 42802208 | PubTator, text mining | PubMed |
| Association of solute carrier family 19 member 1 (SLC19A1) A80G polymorphism with the maternal risk for having a child with Down syndrome: A systematic review and meta-analysis. | Mutat Res Rev Mutat Res | 2026 | 42762765 | PubTator, text mining | PubMed |
| Cramps as the initial presentation of CANVAS/RFC1-related disorder. | J Neuromuscul Dis | 2026 | 42758088 | PubTator, text mining | PubMed |
| Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1. | Brain Pathol | 2026 | 42757740 | PubTator, text mining | PubMed |
| Non-coding repeat expansions within NOTCH2NLC and RFC1 genes contribute to unsolved inherited peripheral neuropathies. | J Hum Genet | 2026 | 42716992 | PubTator, text mining | PubMed |
| Characteristics of a Cohort of Individuals With SCA27B Associated With Repeat Expansions in FGF14. | Neurol Genet | 2026 | 42699715 | PubTator, text mining | PubMed |
| Optimized Cas9-Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders. | Adv Sci (Weinh) | 2026 | 42667167 | PubTator, text mining | PubMed |
| The Genetic Architecture of Chronic Cough: From Sensory Hypersensitivity to Treatable Trait. | Pulm Ther | 2026 | 42633611 | PubTator, text mining | PubMed |
1 to 10 of 2,391
See all 2,391 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5981
GET https://conductscience.org/api/genes/v1/5981/patents?page=2