ConductScience.org, home

Gene · 5981

RFC1: replication factor C subunit 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. RFC1: replication factor C subunit 1. Genes, record 5981. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5981

On this page

Gene

Symbol
RFC1
HGNC
Name
replication factor C subunit 1
HGNC
NCBI Gene ID
5981
NCBI Gene
HGNC ID
HGNC:9969
HGNC
Ensembl
ENSG00000035928
NCBI Gene
Aliases
A1, CANVAS, MHCBFB, PO-GA, RECC1, RFC, RFC140
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35251Replication factor C subunit 11,1484Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2910840P35251Espacenet
JP 2025517969 A2025-06-1210840P35251Espacenet
EP 4464338 A22024-11-20363P35251Espacenet
JP 2024123008 A2024-09-108164P35251Espacenet
US 11680268 B22023-06-20363P35251Espacenet
US 11446398 B22022-09-2072595P35251Espacenet
JP 2022524081 A2022-04-27175566P35251Espacenet
US 11078247 B22021-08-039511P35251Espacenet
WO 2020043864 A12020-03-052090P35251Espacenet
US 10501513 B22019-12-108164P35251Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,549

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRFC1 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines352025
P01CA013106Targeting Transcription and Splicing in Cancer162025
R01GM050006Enzymology of Mismatch Repair in Yeast92025
R35GM131754Structural mechanism of DNA replication92025
P30CA016672Cancer Center Support Grant82025
R01NS072248Genome Studies in Hereditary Spastic Paraplegia- Beyond the Exome72025
R01GM058015Recombinational Mechanisms of DNA Repair62025
P30CA008748Cancer Center Support Grant52025
P30CA033572Cancer Center Support Grant52025
P30ES010126UNC Center for Environmental Health and Susceptibility52025

1 to 10 of 1,549Source NIH's project files

See all 1,549 nih grants

Papers2,391

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Erratum for the Research Article "AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS neurons" by C. Maltby et al.Sci Adv202642826216PubTator, text miningPubMed
Lightweight CNN recognition of HeLa cell PCNA‑based S‑phase subphases and RFC‑dependent dynamics.Acta Neurobiol Exp (Wars)202642808670PubTator, text miningPubMed
Hereditary and Non-hereditary Cerebellar Ataxias in Latvia: Six Years of Experience at the National Reference Centre (ERN-RND Affiliated Partner).Cerebellum202642802208PubTator, text miningPubMed
Association of solute carrier family 19 member 1 (SLC19A1) A80G polymorphism with the maternal risk for having a child with Down syndrome: A systematic review and meta-analysis.Mutat Res Rev Mutat Res202642762765PubTator, text miningPubMed
Cramps as the initial presentation of CANVAS/RFC1-related disorder.J Neuromuscul Dis202642758088PubTator, text miningPubMed
Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1.Brain Pathol202642757740PubTator, text miningPubMed
Non-coding repeat expansions within NOTCH2NLC and RFC1 genes contribute to unsolved inherited peripheral neuropathies.J Hum Genet202642716992PubTator, text miningPubMed
Characteristics of a Cohort of Individuals With SCA27B Associated With Repeat Expansions in FGF14.Neurol Genet202642699715PubTator, text miningPubMed
Optimized Cas9-Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders.Adv Sci (Weinh)202642667167PubTator, text miningPubMed
The Genetic Architecture of Chronic Cough: From Sensory Hypersensitivity to Treatable Trait.Pulm Ther202642633611PubTator, text miningPubMed

1 to 10 of 2,391

See all 2,391 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5981

GET https://conductscience.org/api/genes/v1/5981/patents?page=2