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Gene · 5987

TRIM27: tripartite motif containing 27

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRIM27: tripartite motif containing 27. Genes, record 5987. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5987

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Gene

Symbol
TRIM27
HGNC
Name
tripartite motif containing 27
HGNC
NCBI Gene ID
5987
NCBI Gene
HGNC ID
HGNC:9975
HGNC
Ensembl
ENSG00000204713
NCBI Gene
Aliases
RFP, RNF76
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P14373Zinc finger protein RFP5130Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468003P14373Espacenet
JP 2026004568 A2026-01-1468004P14373Espacenet
JP 2026004568 A2026-01-1468012P14373Espacenet
JP 2026004568 A2026-01-1468013P14373Espacenet
JP 2026004568 A2026-01-1468015P14373Espacenet
EP 4641201 A22025-10-2910155P14373Espacenet
WO 2025173787 A2025-08-2112P14373Espacenet
JP 2025517969 A2025-06-1210155P14373Espacenet
JP 2024161501 A2024-11-1954P14373Espacenet
KR 1020240108531 A2024-07-0954P14373Espacenet

1 to 10 of 63

See all 63 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,792

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRIM27 papersNewest fiscal year
P30CA016672Cancer Center Support Grant162025
P30CA008748Cancer Center Support Grant122025
T32CA121938UCSD Cancer Center Training Program in Drug Development62025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center52025
P30CA068485Cancer Center Support Grant42025
P30DK020593Vanderbilt Diabetes Research Center42025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
R01DK073368Mechanisms of Compartmentalized cAMP Signaling42025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA016058Cancer Center Support Grant32025

1 to 10 of 1,792Source NIH's project files

See all 1,792 nih grants

Papers2,241

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell-intrinsic control of endosomal dynamics.bioRxiv202642818731PubTator, text miningPubMed
CRM1-Dependent Cytoplasmic Accumulation of TRIM27 Is Associated with Glomerular Endothelial Cell Injury in Lupus Nephritis.Cells202642782796PubTator, text miningPubMed
GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27-mediated ACLY Ubiquitination and Lipid Metabolism.Adv Sci (Weinh)202642669779PubTator, text miningPubMed
BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells.Adv Sci (Weinh)202642593831PubTator, text miningPubMed
TRIM27-Cas9-loaded EVs suppress HCC proliferation and enhance responsiveness to anti-PD-1 therapy by promoting ACSL4-mediated ferroptosis.Cell Death Differ202642509343PubTator, text miningPubMed
Machine Learning Models for Local Optimization of Red Fluorescent Protein Variants in a Low-Data Setting.J Chem Inf Model202642443100PubTator, text miningPubMed
HMGB1 ubiquitination inhibition and extracellular secretion, mediated by m6A modified-exosomal lncRNA MALAT1, creates a communication between NK92-MI cells and tumor cells to aggravate acute lymphoblastic leukemia.
Cancer Immunol Immunother202642390539PubTator, text miningPubMed
Integrating whole-genome bisulfite sequencing and TCGA data reveals methylation patterns associated with the MTHFR 677 C > T Variant.Sci Rep202642373686PubTator, text miningPubMed
A novel oral vaccine strategy utilizing a plasmid with CAG promoter-driven alphavirus RdRp for Co-expression of NA epitope and adjuvant in attenuated Salmonella boosts immune responses against H9N2 in mice.
Microb Pathog202642297223PubTator, text miningPubMed
Mechanisms of USP7/MAGEL2 Complex Assembly and Its Mutational Disruption in Neurodevelopmental Diseases.bioRxiv202642094436PubTator, text miningPubMed

1 to 10 of 2,241

See all 2,241 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5987

GET https://conductscience.org/api/genes/v1/5987/patents?page=2