Gene · 5997
RGS2: regulator of G protein signaling 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RGS2: regulator of G protein signaling 2. Genes, record 5997. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5997
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P41220 | Regulator of G protein signaling 2 | 211 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents71
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 909 | P41220 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4392 | P41220 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 909 | P41220 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34790 | P41220 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4392 | P41220 | Espacenet |
| WO 2024252368 A2 | 2024-12-12 | 45 | P41220 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 34790 | P41220 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8158 | P41220 | Espacenet |
| JP 2024112982 A | 2024-08-21 | 4412 | P41220 | Espacenet |
| US 12006548 B2 | 2024-06-11 | 591 | P41220 | Espacenet |
1 to 10 of 71
See all 71 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,365
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RGS2 papers | Newest fiscal year |
|---|---|---|---|
| ZIAAI000738 | Control of G-protein Signaling: Role of RGSs | 10 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 5 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| R01HL134850 | Angiotensin receptor G protein signal switching in AgRP neurons in cardiometabolic control | 5 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 4 | 2025 |
| P51OD011132 | Emory National Primate Research Center | 4 | 2025 |
| ZIAAI000746 | Heterotrimeric G Protein Signaling In Allergic Inflammation | 4 | 2025 |
| ZIAAI000939 | Regulation of Normal and Asthmatic Lung Function by G-Protein-Coupled Receptors | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,365Source NIH's project files
See all 1,365 nih grantsPapers1,532
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Although myeloid-cell RGS2 knockout does not affect Ang II-induced hypertension/organ damage in mice, high RGS2 in Gitelman/Bartter syndromes-human models of endogenous Ang II signaling antagonism-is associated with hypotensive/antiremodeling effects. | Physiol Rep | 2026 | 42765426 | PubTator, text mining | PubMed |
| Epigenetic repression of RGS2 transcription by HDAC5 contributes to deep vein thrombosis. | Life Sci | 2026 | 42617796 | PubTator, text mining | PubMed |
| Betaine Downregulates RARRES1 to Alleviate Cartilage Fibrosis and Promote Hyaline Cartilage Repair. | Int J Mol Sci | 2026 | 42589340 | PubTator, text mining | PubMed |
| Regulatory T cells establish an IL-10-IL10Rα immunometabolic checkpoint that limits HSL activation and lipolysis. | bioRxiv | 2026 | 42523439 | PubTator, text mining | PubMed |
| Transcriptomic remodeling of bone marrow mesenchymal stromal cells in pediatric B-cell acute lymphoblastic leukemia: a four-gene signature. | Transl Pediatr | 2026 | 42433948 | PubTator, text mining | PubMed |
| Regulation of RGS2 is an important piece to the puzzle of syncytiotrophoblast dysfunction in preeclampsia. | Physiol Genomics | 2026 | 42371061 | PubTator, text mining | PubMed |
| Corrigendum to: RGS2 promotes brain metastasis of cisplatin-resistant non-small cell lung cancer through caspase-1/IL-1beta signaling pathway. | Neuro Oncol | 2026 | 42178173 | PubTator, text mining | PubMed |
| Secretory Lysosome-Related Gene Signature Defines the Immune Microenvironment and Identifies RGS2 as a Prometastatic Factor in Hepatocellular Carcinoma. | Hum Mutat | 2026 | 42147807 | PubTator, text mining | PubMed |
| Photodynamic therapy remodels the prostate cancer microenvironment by suppressing cancer-associated fibroblast-mediated calcium signaling. | J Photochem Photobiol B | 2026 | 42024997 | PubTator, text mining | PubMed |
| RGS2 facilitates trophoblast function through a loop with the Hippo pathway and ubiquitination of CTGF. | Biochem Pharmacol | 2026 | 41962779 | PubTator, text mining | PubMed |
1 to 10 of 1,532
See all 1,532 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5997
GET https://conductscience.org/api/genes/v1/5997/patents?page=2