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Gene · 5997

RGS2: regulator of G protein signaling 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RGS2: regulator of G protein signaling 2. Genes, record 5997. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5997

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Gene

Symbol
RGS2
HGNC
Name
regulator of G protein signaling 2
HGNC
NCBI Gene ID
5997
NCBI Gene
HGNC ID
HGNC:9998
HGNC
Ensembl
ENSG00000116741
NCBI Gene
Aliases
G0S8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41220Regulator of G protein signaling 22114Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19909P41220Espacenet
EP 4641202 A22025-10-294392P41220Espacenet
JP 2025517970 A2025-06-12909P41220Espacenet
JP 2025032204 A2025-03-1134790P41220Espacenet
KR 1020250017231 A2025-02-044392P41220Espacenet
WO 2024252368 A22024-12-1245P41220Espacenet
EP 4461818 A22024-11-1334790P41220Espacenet
JP 2024123008 A2024-09-108158P41220Espacenet
JP 2024112982 A2024-08-214412P41220Espacenet
US 12006548 B22024-06-11591P41220Espacenet

1 to 10 of 71

See all 71 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,365

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRGS2 papersNewest fiscal year
ZIAAI000738Control of G-protein Signaling: Role of RGSs102025
P30CA016086Cancer Center Support Grant52025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
R01HL134850Angiotensin receptor G protein signal switching in AgRP neurons in cardiometabolic control52025
P30ES013508Center of Excellence in Environmental Toxicology42025
P51OD011132Emory National Primate Research Center42025
ZIAAI000746Heterotrimeric G Protein Signaling In Allergic Inflammation42025
ZIAAI000939Regulation of Normal and Asthmatic Lung Function by G-Protein-Coupled Receptors42025
P30CA016058Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 1,365Source NIH's project files

See all 1,365 nih grants

Papers1,532

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Although myeloid-cell RGS2 knockout does not affect Ang II-induced hypertension/organ damage in mice, high RGS2 in Gitelman/Bartter syndromes-human models of endogenous Ang II signaling antagonism-is associated with hypotensive/antiremodeling effects.
Physiol Rep202642765426PubTator, text miningPubMed
Epigenetic repression of RGS2 transcription by HDAC5 contributes to deep vein thrombosis.Life Sci202642617796PubTator, text miningPubMed
Betaine Downregulates RARRES1 to Alleviate Cartilage Fibrosis and Promote Hyaline Cartilage Repair.Int J Mol Sci202642589340PubTator, text miningPubMed
Regulatory T cells establish an IL-10-IL10Rα immunometabolic checkpoint that limits HSL activation and lipolysis.bioRxiv202642523439PubTator, text miningPubMed
Transcriptomic remodeling of bone marrow mesenchymal stromal cells in pediatric B-cell acute lymphoblastic leukemia: a four-gene signature.Transl Pediatr202642433948PubTator, text miningPubMed
Regulation of RGS2 is an important piece to the puzzle of syncytiotrophoblast dysfunction in preeclampsia.Physiol Genomics202642371061PubTator, text miningPubMed
Corrigendum to: RGS2 promotes brain metastasis of cisplatin-resistant non-small cell lung cancer through caspase-1/IL-1beta signaling pathway.Neuro Oncol202642178173PubTator, text miningPubMed
Secretory Lysosome-Related Gene Signature Defines the Immune Microenvironment and Identifies RGS2 as a Prometastatic Factor in Hepatocellular Carcinoma.Hum Mutat202642147807PubTator, text miningPubMed
Photodynamic therapy remodels the prostate cancer microenvironment by suppressing cancer-associated fibroblast-mediated calcium signaling.J Photochem Photobiol B202642024997PubTator, text miningPubMed
RGS2 facilitates trophoblast function through a loop with the Hippo pathway and ubiquitination of CTGF.Biochem Pharmacol202641962779PubTator, text miningPubMed

1 to 10 of 1,532

See all 1,532 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5997

GET https://conductscience.org/api/genes/v1/5997/patents?page=2