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Gene · 5999

RGS4: regulator of G protein signaling 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RGS4: regulator of G protein signaling 4. Genes, record 5999. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5999

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Gene

Symbol
RGS4
HGNC
Name
regulator of G protein signaling 4
HGNC
NCBI Gene ID
5999
NCBI Gene
HGNC ID
HGNC:10000
HGNC
Ensembl
ENSG00000117152
NCBI Gene
Aliases
RGP4, SCZD9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49798Regulator of G protein signaling 42050Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461281P49798Espacenet
EP 4650780 A22025-11-198318P49798Espacenet
EP 4641201 A22025-10-298513P49798Espacenet
JP 2025517969 A2025-06-128513P49798Espacenet
JP 2025517970 A2025-06-128318P49798Espacenet
JP 2025032204 A2025-03-1134798P49798Espacenet
EP 4461818 A22024-11-1334798P49798Espacenet
JP 2023058610 A2023-04-2534798P49798Espacenet
US 11446398 B22022-09-2072362P49798Espacenet
JP 2022524081 A2022-04-27175333P49798Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,299

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRGS4 papersNewest fiscal year
ZIAAI000939Regulation of Normal and Asthmatic Lung Function by G-Protein-Coupled Receptors72025
ZIAAI000746Heterotrimeric G Protein Signaling In Allergic Inflammation62025
P30CA016672Cancer Center Support Grant52025
R28AA012725Brain Tissue Resource Center for Alcohol Research42025
UL1TR001863Yale Clinical and Translational Science Award42025
P20GM113131Center of Integrated Biomedical and Bioengineering Research (CIBBR)32025
P30CA016086Cancer Center Support Grant32025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202832025
P30CA086862Cancer Center Support Grant32025
P30ES005605Environmental Health Sciences Research Center32025

1 to 10 of 1,299Source NIH's project files

See all 1,299 nih grants

Papers1,442

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The single nucleotide polymorphism rs12041948 influences CDX4-Mediated RGS4 gene expression.Gene202642542172PubTator, text miningPubMed
RGS Family Remodeling in Breast Cancer: A Meta-Analysis and Multi-Omics Profiling of Prognostic Biomarkers.Cancer Med202642520291PubTator, text miningPubMed
Region-specific Transcriptomic Signatures in Alzheimer's Disease: A Meta-analysis of Vulnerable Brain Regions Reveals MicroRNA-hub Gene Regulatory Networks.J Med Signals Sens202642434351PubTator, text miningPubMed
GATA6 marks fibrosis-associated stromal cells rather than repair macrophages in kidney disease.Sci Rep202642426262PubTator, text miningPubMed
Localization of O₂‑sensing ADO‑RGS pathway components in mouse and human kidneys under normoxia, hypoxia and renal fibrosis.Pflugers Arch202642343042PubTator, text miningPubMed
Integrating single-cell and bulk RNA sequencing data reveals RGS4 as a functional driver in a proliferative subgroup of SF-1 lineage PitNETs.Front Cell Dev Biol202642099385PubTator, text miningPubMed
Network pharmacology-based discovery and experimental validation of novel drug repurposing candidates in Alzheimer's Disease.bioRxiv202641959283PubTator, text miningPubMed
The hippo-YAP1/TEAD1-SLC7A5 axis: uncovering a novel therapeutic target for oxalate-induced renal tubular ferroptosis.Redox Rep202641833934PubTator, text miningPubMed
Transcriptomic analysis and machine learning have identified shared diagnostic genes and a possible mechanism linking bipolar disorder and epilepsy.Medicine (Baltimore)202641790636PubTator, text miningPubMed
Potential Biological Processes Related to Brain SLC13A5 Across the Lifespan: Weighted Gene Co-Expression Network Analysis from Large Human Transcriptomic Data.Brain Sci202641750164PubTator, text miningPubMed

1 to 10 of 1,442

See all 1,442 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5999

GET https://conductscience.org/api/genes/v1/5999/patents?page=2