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Gene · 6036

RNASE2: ribonuclease A family member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RNASE2: ribonuclease A family member 2. Genes, record 6036. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6036

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Gene

Symbol
RNASE2
HGNC
Name
ribonuclease A family member 2
HGNC
NCBI Gene ID
6036
NCBI Gene
HGNC ID
HGNC:10045
HGNC
Ensembl
ENSG00000169385
NCBI Gene
Aliases
EDN, RAF3, RNS2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10153Non-secretory ribonuclease16127Ensembl, GeneID, HGNC

Source UniProt

Patents55

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461921P10153Espacenet
EP 4650780 A22025-11-194204P10153Espacenet
WO 2025217591 A12025-10-1689P10153Espacenet
JP 2025147176 A2025-10-0611450P10153Espacenet
JP 2025529142 A2025-09-047575P10153Espacenet
US 12371689 B22025-07-297575P10153Espacenet
JP 2025517970 A2025-06-124204P10153Espacenet
JP 2025028160 A2025-02-2811450P10153Espacenet
KR 1020250010750 A2025-01-2111450P10153Espacenet
JP 2024109657 A2024-08-1411457P10153Espacenet

1 to 10 of 55

See all 55 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants906

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRNASE2 papersNewest fiscal year
U19AI070235Epithelial Genes in Allergic Inflammation132025
ZIAAI001130Eosinophils and Eosinophil Activation in the Pathogenesis of Human Disease122025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease72025
T32AI007635Wisconsin Allergy Research Training (WiscART) Program62025
ZIAAI000197Immunoregulation /Immune Recognition In Filarial/Nonfilarial Parasitic Infection52025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
R01AI124355Genetic and Immunological Dissection of Eosinophilic Esophagitis42025
U19AI104317Interactions Between the Microbiome, Immunity and Respiratory Health in Traditional Agrarian and Suburban children32025
ZIAAI000439Clinical And Therapeutic Studies Of Human Filariasis and Related Diseases32025
P30CA014520UW Comprehensive Cancer Center Support22025

1 to 10 of 906Source NIH's project files

See all 906 nih grants

Papers2,203

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Survival-Associated Molecular and Epigenetic Alterations in Endocervical Adenocarcinoma: An Exploratory TCGA Multi-Omics Cohort Study.Curr Issues Mol Biol202642793237PubTator, text miningPubMed
The Utility of Faecal Biomarkers in the Discrimination Between Acute Gastroenteritis and Inflammatory Bowel Disease.Biomedicines202642792694PubTator, text miningPubMed
Identification of MMP8, DDX24, RNASE2, and EMB as a novel diagnostic gene panel for sepsis: a transcriptome-based modeling study.Front Immunol202642769250PubTator, text miningPubMed
Blood Eosinophil Subtype-Specific Protein Gene Expression and Eosinophil-Derived Serum Mediators in Allergic Asthma Patients After Bronchial Challenge with Dermatophagoides pteronyssinus.Cells202642738872PubTator, text miningPubMed
Distinct Inflammation-Associated Microbiome Signatures in Pediatric Non-IgE-Mediated Food Allergy.Int J Mol Sci202642653482PubTator, text miningPubMed
Estimation of biological variability of inflammatory biomarkers EDN, suPAR and plasma calprotectin.Scand J Clin Lab Invest202642613719PubTator, text miningPubMed
Integrative analysis of methylation-driven genes and macrophage subtypes defines prognostic biomarkers in clear-cell renal cell carcinoma.Comput Methods Biomech Biomed Engin202642537693PubTator, text miningPubMed
Rhinovirus-infected preschool children with problematic wheeze have lung eosinophilic inflammation.J Allergy Clin Immunol202642468745PubTator, text miningPubMed
Serum EDN as a novel biomarker for severe eosinophilic adult asthma.Allergol Immunopathol (Madr)202642433053PubTator, text miningPubMed
Longer Asthma Duration Is Associated With Elevated Non-T2 Sputum Biomarkers and Reduced T2 Inflammation in Severe Asthma.Allergy202642423296PubTator, text miningPubMed

1 to 10 of 2,203

See all 2,203 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6036

GET https://conductscience.org/api/genes/v1/6036/patents?page=2