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Gene · 6041

RNASEL: ribonuclease L

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RNASEL: ribonuclease L. Genes, record 6041. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6041

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Gene

Symbol
RNASEL
HGNC
Name
ribonuclease L
HGNC
NCBI Gene ID
6041
NCBI Gene
HGNC ID
HGNC:10050
HGNC
Ensembl
ENSG00000135828
NCBI Gene
Aliases
PRCA1, RNS4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q058232-5A-dependent ribonuclease7415Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026148146 A12026-07-0930Q05823Espacenet
JP 2026094314 A2026-06-0988Q05823Espacenet
JP 2026021360 A2026-02-10130Q05823Espacenet
JP 2026004568 A2026-01-1461867Q05823Espacenet
JP 2026004568 A2026-01-1461868Q05823Espacenet
EP 4650780 A22025-11-198250Q05823Espacenet
WO 2025217591 A12025-10-1686Q05823Espacenet
JP 2025517970 A2025-06-128250Q05823Espacenet
JP 2025041709 A2025-03-26111Q05823Espacenet
EP 4518908 A22025-03-126Q05823Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,143

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRNASEL papersNewest fiscal year
R01AI140442Betacoronaviruses: activation and antagonism of host innate immune responses152025
R01CA249180Targeted degradation of RNAs by using small molecules122025
P30CA006973Regional Oncology Research Center92025
R35NS116846Design of Precision Small Molecules Targeting RNA Repeating Transcripts to Manipulate and Study Disease Biology92025
P30CA046934University of Colorado Cancer Center Support Grant72025
R01AI169537Human coronavirus infection of the nasal epithelium72025
R01CA136367Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated Herpesvirus72025
R35GM151249Understanding the OAS/RNase L pathway during pathogenic viral infections72025
P30CA008748Cancer Center Support Grant62025
P30CA054174Mays Cancer Center at UT Health SA62025

1 to 10 of 2,143Source NIH's project files

See all 2,143 nih grants

Papers3,466

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Interferon-stimulated restriction factors in enterovirus infection: A review on the mechanisms and antiviral roles of shiftless (C19orf66).Virology202742784970PubTator, text miningPubMed
Benzothiazole derivatives target oligoadenylate synthetase and enhance RSV vaccine efficacy as adjuvants.Bioact Mater202742592354PubTator, text miningPubMed
Tumour-associated dsRNA accumulation and innate immune activation: mechanistic basis and therapeutic strategies.EBioMedicine202642800308PubTator, text miningPubMed
West African Clade C MERS-CoV Strains BF785 and Mor213 Induce More Robust Interferon and Inflammatory Signaling Compared to Clade A in Human Respiratory Cells.Viruses202642797768PubTator, text miningPubMed
Enterovirus RNase L inhibiting RNAs are highly conserved with limited phylogenetic distribution.RNA202642772853PubTator, text miningPubMed
Linker Optimization of cMYC RIBOTAC for Efficient cMYC Modulation.ChemMedChem202642745536PubTator, text miningPubMed
Association of selected ELAC2, MSR1, RNASEL and KLK3 polymorphisms with prostate cancer susceptibility in a Hungarian cohort.Pathol Oncol Res202642729212PubTator, text miningPubMed
Systemic removal of host restriction factors enables rapid, scalable virus production for cell culture-based vaccine development.Front Bioeng Biotechnol202642698639PubTator, text miningPubMed
RIBOTAC-mediated degradation of hsa-microRNA-301a-3p suppresses TNBC bone metastasis.Sci Adv202642647607PubTator, text miningPubMed
Tumour-Derived Extracellular Vesicles Containing dsRNA Induce Degradation of Ribosomal Protein mRNA in Platelets.J Extracell Vesicles202642572919PubTator, text miningPubMed

1 to 10 of 3,466

See all 3,466 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6041

GET https://conductscience.org/api/genes/v1/6041/patents?page=2