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Gene · 6045

RNF2: ring finger protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RNF2: ring finger protein 2. Genes, record 6045. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6045

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Gene

Symbol
RNF2
HGNC
Name
ring finger protein 2
HGNC
NCBI Gene ID
6045
NCBI Gene
HGNC ID
HGNC:10061
HGNC
Ensembl
ENSG00000121481
NCBI Gene
Aliases
BAP-1, BAP1, DING, HIPI3, LUSYAM, RING1B, RING2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99496E3 ubiquitin-protein ligase RING233627Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462271Q99496Espacenet
EP 4650780 A22025-11-198246Q99496Espacenet
JP 2025517970 A2025-06-128246Q99496Espacenet
JP 2023529026 A2023-07-0681Q99496Espacenet
US 11446398 B22022-09-2074930Q99496Espacenet
JP 2022524081 A2022-04-27177901Q99496Espacenet
JP 2019054813 A2019-04-11242706Q99496Espacenet
JP 2017121241 A2017-07-13242706Q99496Espacenet
JP 2015516143 A2015-06-08242706Q99496Espacenet
US 8349555 B22013-01-0862Q99496Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,523

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRNF2 papersNewest fiscal year
RM1HG009490Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease142025
P30CA008748Cancer Center Support Grant122025
R35GM118062Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics112025
P30CA016672Cancer Center Support Grant92025
P30CA054174Mays Cancer Center at UT Health SA92025
P30CA016086Cancer Center Support Grant82025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability82025
ZIAAG000753Fanconi Anemia Pathway82025
R01CA097098Targeting the MUC1-C Oncoprotein in Triple-Negative Breast Cancer72025
P01CA092584Structural Cell Biology of DNA Repair Machines62025

1 to 10 of 1,523Source NIH's project files

See all 1,523 nih grants

Papers2,066

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SMC1A drives radioresistance in lung squamous cell carcinoma through the ILF2/RNF2 axis.Biochim Biophys Acta Mol Basis Dis202742727711PubTator, text miningPubMed
Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1.Nat Struct Mol Biol202642736418PubTator, text miningPubMed
Cloning of human DING: Developmental expression and downregulation by EtOH in-utero.Arch Intern Med Res202642683440PubTator, text miningPubMed
BRD4 represses developmental and neuronal genes through interaction with PRC1.6.bioRxiv202642619710PubTator, text miningPubMed
Citrullination in proteins of the polycomb repressor complex 1.Arch Biochem Biophys202642546893PubTator, text miningPubMed
Topic: boron toxicity in semi-arid crops: the overlooked metalloid in abiotic stress.Physiol Mol Biol Plants202642358426PubTator, text miningPubMed
TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells.Nat Cell Biol202642277434PubTator, text miningPubMed
Disrupting the CBFβ-SMMHC-RUNX1 oncogenic protein-protein interaction in inv(16) AML: from fusion biology to targeted therapy.Discov Oncol202642142238PubTator, text miningPubMed
Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria to nucleus signaling.bioRxiv202642079170PubTator, text miningPubMed
RYBP regulates selective genomic binding of TrxG and PcG components in embryonic stem cell fate control.EMBO J202642049912PubTator, text miningPubMed

1 to 10 of 2,066

See all 2,066 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6045

GET https://conductscience.org/api/genes/v1/6045/patents