Gene · 6045
RNF2: ring finger protein 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RNF2: ring finger protein 2. Genes, record 6045. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6045
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99496 | E3 ubiquitin-protein ligase RING2 | 336 | 27 | Ensembl, GeneID, HGNC |
Source UniProt
Patents18
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 62271 | Q99496 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8246 | Q99496 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8246 | Q99496 | Espacenet |
| JP 2023529026 A | 2023-07-06 | 81 | Q99496 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 74930 | Q99496 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 177901 | Q99496 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 242706 | Q99496 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 242706 | Q99496 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 242706 | Q99496 | Espacenet |
| US 8349555 B2 | 2013-01-08 | 62 | Q99496 | Espacenet |
1 to 10 of 18
See all 18 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,523
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RNF2 papers | Newest fiscal year |
|---|---|---|---|
| RM1HG009490 | Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease | 14 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 9 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 8 | 2025 |
| ZIAAG000741 | Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability | 8 | 2025 |
| ZIAAG000753 | Fanconi Anemia Pathway | 8 | 2025 |
| R01CA097098 | Targeting the MUC1-C Oncoprotein in Triple-Negative Breast Cancer | 7 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 6 | 2025 |
1 to 10 of 1,523Source NIH's project files
See all 1,523 nih grantsPapers2,066
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| SMC1A drives radioresistance in lung squamous cell carcinoma through the ILF2/RNF2 axis. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42727711 | PubTator, text mining | PubMed |
| Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1. | Nat Struct Mol Biol | 2026 | 42736418 | PubTator, text mining | PubMed |
| Cloning of human DING: Developmental expression and downregulation by EtOH in-utero. | Arch Intern Med Res | 2026 | 42683440 | PubTator, text mining | PubMed |
| BRD4 represses developmental and neuronal genes through interaction with PRC1.6. | bioRxiv | 2026 | 42619710 | PubTator, text mining | PubMed |
| Citrullination in proteins of the polycomb repressor complex 1. | Arch Biochem Biophys | 2026 | 42546893 | PubTator, text mining | PubMed |
| Topic: boron toxicity in semi-arid crops: the overlooked metalloid in abiotic stress. | Physiol Mol Biol Plants | 2026 | 42358426 | PubTator, text mining | PubMed |
| TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells. | Nat Cell Biol | 2026 | 42277434 | PubTator, text mining | PubMed |
| Disrupting the CBFβ-SMMHC-RUNX1 oncogenic protein-protein interaction in inv(16) AML: from fusion biology to targeted therapy. | Discov Oncol | 2026 | 42142238 | PubTator, text mining | PubMed |
| Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria to nucleus signaling. | bioRxiv | 2026 | 42079170 | PubTator, text mining | PubMed |
| RYBP regulates selective genomic binding of TrxG and PcG components in embryonic stem cell fate control. | EMBO J | 2026 | 42049912 | PubTator, text mining | PubMed |
1 to 10 of 2,066
See all 2,066 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6045
GET https://conductscience.org/api/genes/v1/6045/patents