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Gene · 6046

BRD2: bromodomain containing 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BRD2: bromodomain containing 2. Genes, record 6046. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6046

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Gene

Symbol
BRD2
HGNC
Name
bromodomain containing 2
HGNC
NCBI Gene ID
6046
NCBI Gene
HGNC ID
HGNC:1103
HGNC
Ensembl
ENSG00000204256
NCBI Gene
Aliases
BRD2-IT1, D6S113E, FSH, FSHRG1, FSRG1, KIAA9001, NAT, O27.1.1, RING3, RNF3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25440Bromodomain-containing protein 2801174Ensembl, GeneID, HGNC

Source UniProt

Patents110

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16713P25440Espacenet
JP 2026004568 A2026-01-1439198P25440Espacenet
JP 2026004568 A2026-01-1439199P25440Espacenet
JP 2026004568 A2026-01-1439200P25440Espacenet
JP 2026004568 A2026-01-1439204P25440Espacenet
JP 2026004568 A2026-01-1439205P25440Espacenet
JP 2026004568 A2026-01-1439215P25440Espacenet
JP 2026004568 A2026-01-1439243P25440Espacenet
WO 2025243001 A12025-11-272P25440Espacenet
EP 4650780 A22025-11-199530P25440Espacenet

1 to 10 of 110

See all 110 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APABETALONECHEMBL2393130Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
BIRABRESIBCHEMBL3581647Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
EZOBRESIBCHEMBL4297458Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
MOLIBRESIBCHEMBL1232461Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
PELABRESIBCHEMBL4303404Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
RO-6870810CHEMBL4297423Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL

Trials42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07357727PELABRESIBPHASE3ClinicalTrials.gov
NCT07340138PELABRESIBPHASE1ClinicalTrials.gov
NCT06590324APABETALONEPHASE2/PHASE3ClinicalTrials.gov
NCT06401356PELABRESIBPHASE3ClinicalTrials.gov
NCT05372354EZOBRESIBPHASE1/PHASE2ClinicalTrials.gov
NCT04915300APABETALONEPHASE2ClinicalTrials.gov
NCT04894266APABETALONEPHASE2/PHASE3ClinicalTrials.gov
NCT04817007EZOBRESIBPHASE1/PHASE2ClinicalTrials.gov
NCT04603495PELABRESIBPHASE32024-10-28ClinicalTrials.gov
NCT03936465EZOBRESIBPHASE1ClinicalTrials.gov

1 to 10 of 42

See all 42 trials

NIH grants2,589

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBRD2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant192025
P30CA008748Cancer Center Support Grant162025
R35CA197589Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities132025
P30CA010815Consolidated Basic Cancer Research Program122025
P30CA021765Cancer Center Support Grant (CCSG)122025
P30AI027763UCSF-Bay Area Center for AIDS Research102025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028102025
P30CA068485Cancer Center Support Grant102025
P30CA076292Moffitt Cancer Center Support Grant102025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias82025

1 to 10 of 2,589Source NIH's project files

See all 2,589 nih grants

Papers3,414

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MAPK signaling links BRD2 chromatin occupancy to PI3K/AKT inhibitor sensitivity.bioRxiv202642818240PubTator, text miningPubMed
Correction to 'INO80/SWR remodelers regulate Pol II transcription through BRD2 and chromatin landscape'.Nucleic Acids Res202642741843PubTator, text miningPubMed
BRD2-Mediated TGR5 destabilization impairs fatty acid oxidation and drives tubular ferroptosis in diabetic kidney injury.Free Radic Biol Med202642685932PubTator, text miningPubMed
BRD4: From molecular understanding to therapeutics development.Mol Cell202642492506PubTator, text miningPubMed
Neuroinflammation- molecular target based therapeutic approach.Adv Protein Chem Struct Biol202642448410PubTator, text miningPubMed
Targeting bromodomain and extraterminal proteins in cardiovascular disease: Pathological mechanisms and therapeutic applications.J Int Med Res202642426583PubTator, text miningPubMed
Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters.J Cardiovasc Aging202642369572PubTator, text miningPubMed
Single-cell and spatial transcriptomic colocalization analysis reveals the roles of histone deacetylation in lung adenocarcinoma progression and microenvironment.Transl Res202642336135PubTator, text miningPubMed
Identification of macrophage-enriched genes in ovarian cancer by single-cell RNA sequencing and establishment of a prognosis model.Sci Rep202642324278PubTator, text miningPubMed
EVs-MSC alleviate RA progression via USP21-dependent BRD2 stabilization to regulate autophagy in FLS.Biochem Pharmacol202642302977PubTator, text miningPubMed

1 to 10 of 3,414

See all 3,414 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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