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Gene · 60675

PROK2: prokineticin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PROK2: prokineticin 2. Genes, record 60675. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/60675

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Gene

Symbol
PROK2
HGNC
Name
prokineticin 2
HGNC
NCBI Gene ID
60675
NCBI Gene
HGNC ID
HGNC:18455
HGNC
Ensembl
ENSG00000163421
NCBI Gene
Aliases
BV8, HH4, KAL4, MIT1, PK2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HC23Prokineticin-21290Ensembl, GeneID, HGNC

Source UniProt

Patents55

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459156Q9HC23Espacenet
EP 4650780 A22025-11-193631Q9HC23Espacenet
JP 2025147176 A2025-10-0610843Q9HC23Espacenet
JP 2025529142 A2025-09-047439Q9HC23Espacenet
US 12371689 B22025-07-297439Q9HC23Espacenet
JP 2025517970 A2025-06-123631Q9HC23Espacenet
JP 2025028160 A2025-02-2810843Q9HC23Espacenet
KR 1020250010750 A2025-01-2110843Q9HC23Espacenet
JP 2024109657 A2024-08-1410850Q9HC23Espacenet
US 11446398 B22022-09-2066850Q9HC23Espacenet

1 to 10 of 55

See all 55 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,075

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePROK2 papersNewest fiscal year
P30AI050410The University of North Carolina Center for AIDS Research52025
P30CA016672Cancer Center Support Grant52025
P51OD011092Support for National Primate Research Center32025
R01AI133348Mechanisms of viral RNA maturation by co-opting cellular exonucleases32025
R01HD097331Understanding the role of the transcription factor Gli3 in Kallmann syndrome and normosmic forms of idiopathic hypogonadotropic hypogonadism32025
R35GM118070Structure, function, and dynamics of viral RNAs and RNA-containing complexes32025
I01CX001969Neutrophil Exosomes: New Pathogenic Entities in COPD22025
P30CA008748Cancer Center Support Grant22025
P30CA010815Consolidated Basic Cancer Research Program22025
P30CA014051Cancer Center Support (Core) Grant22025

1 to 10 of 1,075Source NIH's project files

See all 1,075 nih grants

Papers1,805

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identifying JAK2 and ANXA5 as Key Genes Linking Obstructive Sleep Apnea and Oxidative Stress via Machine Learning and Multilayer Transcriptomic Integration With Functional Validation.FASEB J202642730994PubTator, text miningPubMed
Role of Prokineticin-2 and Cytokines in Synovial Fluid in Traumatic Anterior Cruciate Ligament Injuries.Mediators Inflamm202642714063PubTator, text miningPubMed
Double Heterozygous PROK2 p.(Ile55Ter)-PROKR2 p.(Arg85Leu) Variants: Case Report of an Oligogenic Case of Congenital Hypogonadotropic Hypogonadism with Anosmia.Sex Dev202642550786PubTator, text miningPubMed
GIRK Channels Regulate Circadian Rhythms of Excitability in Prokineticin 2 Neurons of the Suprachiasmatic Nucleus and Modulate Behavioral Circadian Rhythms.J Neurosci202642538300PubTator, text miningPubMed
The Pathogenicity Analysis of a Hypogonadotropic Hypogonadism Patient With the Novel Variant in the Deep Intronic Region of the PROK2 Gene.Mol Genet Genomic Med202642449499PubTator, text miningPubMed
Retraction Note: Improving AOX1 promoter efficiency by overexpression of Mit1 transcription factor.Mol Biol Rep202642033504PubTator, text miningPubMed
PROK2 defines a pathogenic neutrophil subset and serves as a clinical indicator of neutrophilic inflammation in COPD.Respir Res202641998641PubTator, text miningPubMed
Prokineticin 2 is upregulated in preeclampsia and impairs trophoblast function.J Matern Fetal Neonatal Med202641936573PubTator, text miningPubMed
Neutrophil-related gene expression profile is associated with future paediatric bronchiectasis exacerbations.J Mol Med (Berl)202641917171PubTator, text miningPubMed
Idiopathic Hypogonadotropic Hypogonadism with a Rare Hemi-Arrhinia: A Case Report with Nasal Reconstruction.J Otolaryngol Head Neck Surg202641902607PubTator, text miningPubMed

1 to 10 of 1,805

See all 1,805 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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