Gene · 60675
PROK2: prokineticin 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PROK2: prokineticin 2. Genes, record 60675. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/60675
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9HC23 | Prokineticin-2 | 129 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents55
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59156 | Q9HC23 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3631 | Q9HC23 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 10843 | Q9HC23 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7439 | Q9HC23 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7439 | Q9HC23 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3631 | Q9HC23 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 10843 | Q9HC23 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 10843 | Q9HC23 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 10850 | Q9HC23 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 66850 | Q9HC23 | Espacenet |
1 to 10 of 55
See all 55 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,075
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PROK2 papers | Newest fiscal year |
|---|---|---|---|
| P30AI050410 | The University of North Carolina Center for AIDS Research | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P51OD011092 | Support for National Primate Research Center | 3 | 2025 |
| R01AI133348 | Mechanisms of viral RNA maturation by co-opting cellular exonucleases | 3 | 2025 |
| R01HD097331 | Understanding the role of the transcription factor Gli3 in Kallmann syndrome and normosmic forms of idiopathic hypogonadotropic hypogonadism | 3 | 2025 |
| R35GM118070 | Structure, function, and dynamics of viral RNAs and RNA-containing complexes | 3 | 2025 |
| I01CX001969 | Neutrophil Exosomes: New Pathogenic Entities in COPD | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 2 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 2 | 2025 |
1 to 10 of 1,075Source NIH's project files
See all 1,075 nih grantsPapers1,805
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identifying JAK2 and ANXA5 as Key Genes Linking Obstructive Sleep Apnea and Oxidative Stress via Machine Learning and Multilayer Transcriptomic Integration With Functional Validation. | FASEB J | 2026 | 42730994 | PubTator, text mining | PubMed |
| Role of Prokineticin-2 and Cytokines in Synovial Fluid in Traumatic Anterior Cruciate Ligament Injuries. | Mediators Inflamm | 2026 | 42714063 | PubTator, text mining | PubMed |
| Double Heterozygous PROK2 p.(Ile55Ter)-PROKR2 p.(Arg85Leu) Variants: Case Report of an Oligogenic Case of Congenital Hypogonadotropic Hypogonadism with Anosmia. | Sex Dev | 2026 | 42550786 | PubTator, text mining | PubMed |
| GIRK Channels Regulate Circadian Rhythms of Excitability in Prokineticin 2 Neurons of the Suprachiasmatic Nucleus and Modulate Behavioral Circadian Rhythms. | J Neurosci | 2026 | 42538300 | PubTator, text mining | PubMed |
| The Pathogenicity Analysis of a Hypogonadotropic Hypogonadism Patient With the Novel Variant in the Deep Intronic Region of the PROK2 Gene. | Mol Genet Genomic Med | 2026 | 42449499 | PubTator, text mining | PubMed |
| Retraction Note: Improving AOX1 promoter efficiency by overexpression of Mit1 transcription factor. | Mol Biol Rep | 2026 | 42033504 | PubTator, text mining | PubMed |
| PROK2 defines a pathogenic neutrophil subset and serves as a clinical indicator of neutrophilic inflammation in COPD. | Respir Res | 2026 | 41998641 | PubTator, text mining | PubMed |
| Prokineticin 2 is upregulated in preeclampsia and impairs trophoblast function. | J Matern Fetal Neonatal Med | 2026 | 41936573 | PubTator, text mining | PubMed |
| Neutrophil-related gene expression profile is associated with future paediatric bronchiectasis exacerbations. | J Mol Med (Berl) | 2026 | 41917171 | PubTator, text mining | PubMed |
| Idiopathic Hypogonadotropic Hypogonadism with a Rare Hemi-Arrhinia: A Case Report with Nasal Reconstruction. | J Otolaryngol Head Neck Surg | 2026 | 41902607 | PubTator, text mining | PubMed |
1 to 10 of 1,805
See all 1,805 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/60675
GET https://conductscience.org/api/genes/v1/60675/patents?page=2