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ROCK1: Rho associated coiled-coil containing protein kinase 1

1 protein, 58 patents, 14 drugs, 87 trials, 2,986 NIH grants and 6,226 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolROCK1HGNC
NameRho associated coiled-coil containing protein kinase 1HGNC
NCBI Gene ID6093NCBI Gene
HGNC IDHGNC:10251HGNC
EnsemblENSG00000067900NCBI Gene
AliasesP160ROCK, ROCK-I, p160ROCKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13464Rho-associated protein kinase 11,35432Ensembl, GeneID, HGNCUniProt

Patents 58

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911684Q13464Espacenet
EP 4641201 A22025-10-2912342Q13464Espacenet
JP 2025517969 A2025-06-1212342Q13464Espacenet
JP 2025517970 A2025-06-1211684Q13464Espacenet
EP 4491229 A22025-01-15231Q13464Espacenet
WO 2024230934 A12024-11-14356Q13464Espacenet
JP 2024123008 A2024-09-108227Q13464Espacenet
JP 2024510010 A2024-03-05218Q13464Espacenet
US 11920164 B22024-03-0550Q13464Espacenet
WO 2022195543 A2022-09-22218Q13464Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMA0076CHEMBL3545073Rho-associated protein kinase inhibitorINHIBITORChEMBL
AT-13148CHEMBL3544960Rho-associated protein kinase inhibitorINHIBITORChEMBL
BELUMOSUDILCHEMBL2005186Rho-associated protein kinase inhibitorINHIBITORChEMBL
BELUMOSUDIL MESYLATECHEMBL4802130Rho-associated protein kinase inhibitorINHIBITORChEMBL
DE-104CHEMBL3545153Rho-associated protein kinase inhibitorINHIBITORChEMBL
FASUDILCHEMBL38380Rho-associated protein kinase inhibitorINHIBITORChEMBL
NETARSUDILCHEMBL4594250Rho-associated protein kinase inhibitorINHIBITORChEMBL
NETARSUDIL DIMESYLATECHEMBL4594251Rho-associated protein kinase inhibitorINHIBITORChEMBL
RIPASUDILCHEMBL3426621Rho-associated protein kinase inhibitorINHIBITORChEMBL
RIPASUDIL HYDROCHLORIDE DIHYDRATECHEMBL4594454Rho-associated protein kinase inhibitorINHIBITORChEMBL

Trials 87

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07588152NETARSUDILPHASE4ClinicalTrials.gov
NCT07484113BELUMOSUDILPHASE1ClinicalTrials.gov
NCT07325240NETARSUDILPHASE4ClinicalTrials.gov
NCT07135973BELUMOSUDILPHASE4ClinicalTrials.gov
NCT07116031BELUMOSUDILPHASE2ClinicalTrials.gov
NCT07082816NETARSUDILPHASE3ClinicalTrials.gov
NCT07048886NETARSUDILPHASE4ClinicalTrials.gov
NCT06969586NETARSUDILClinicalTrials.gov
NCT06960629NETARSUDILPHASE2/PHASE3ClinicalTrials.gov
NCT06883123NETARSUDIL DIMESYLATEPHASE4ClinicalTrials.gov

NIH grants 2986

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant172,025NIH's project files
P30CA016672Cancer Center Support Grant142,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant122,025NIH's project files
P30CA068485Cancer Center Support Grant92,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology72,025NIH's project files
T32NS061788UAB Research Training Program in Neurobiology of Cognition and Cognitive Disorders72,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases62,025NIH's project files
P30EY008098Core Grant for Vision Research62,025NIH's project files
R01AG061800Identifying therapeutic targets that confer synaptic resilience to Alzheimer's disease62,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)52,025NIH's project files

Papers 6226

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818172PubTator, text miningPubMed
42810623PubTator, text miningPubMed
42794553PubTator, text miningPubMed
42766575PubTator, text miningPubMed
42738896PubTator, text miningPubMed
42702991PubTator, text miningPubMed
42699659PubTator, text miningPubMed
42676691PubTator, text miningPubMed
42667212PubTator, text miningPubMed
42647867PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license