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Gene · 6103

RPGR: retinitis pigmentosa GTPase regulator

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPGR: retinitis pigmentosa GTPase regulator. Genes, record 6103. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6103

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Gene

Symbol
RPGR
HGNC
Name
retinitis pigmentosa GTPase regulator
HGNC
NCBI Gene ID
6103
NCBI Gene
HGNC ID
HGNC:10295
HGNC
Ensembl
ENSG00000156313
NCBI Gene
Aliases
COD1, CORDX1, CRD, PCDX, RP15, RP3, XLRP3, orf15
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92834X-linked retinitis pigmentosa GTPase regulator1,0203Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461468Q92834Espacenet
EP 4641201 A22025-10-296633Q92834Espacenet
JP 2025529142 A2025-09-043776Q92834Espacenet
US 12371689 B22025-07-293776Q92834Espacenet
JP 2025517969 A2025-06-126633Q92834Espacenet
US 12310997 B22025-05-27113Q92834Espacenet
US 12246072 B22025-03-1134Q92834Espacenet
KR 1020250023600 A2025-02-18113Q92834Espacenet
EP 4491229 A22025-01-15239Q92834Espacenet
WO 2024230934 A12024-11-14364Q92834Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants858

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPGR papersNewest fiscal year
R01EY006855Models for Therapy of Hereditary Retinal Degeneration302025
R01EY018213Defining Barriers to Gene Therapy252025
P30EY001583P30 Core Grant For Vision Research232025
P30CA013696Cancer Center Support Grant222025
R01EY024698Gene Editing and Silencing in Phototransduction172025
P30EY014104P30 Core Grant for Vision Research152025
R01EY012910Precision Medicine for Inherited Retinal Degenerations122025
R01EY022356Molecular Basis of Human Visual System Disorders122025
R01EY018571Genetics of early onset retinal diseases112025
R01EY017607Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae102025

1 to 10 of 858Source NIH's project files

See all 858 nih grants

Papers1,847

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Tapetal-like reflex in RPGR-associated retinal dystrophies: two cases with distinct phenotypes.Doc Ophthalmol202642758434PubTator, text miningPubMed
IMU-based identification of rowing conditions through supervised machine learning.BMC Sports Sci Med Rehabil202642745342PubTator, text miningPubMed
Progress in gene therapy for RPGR-associated X-linked retinitis pigmentosa.Expert Opin Biol Ther202642733973PubTator, text miningPubMed
Functional Outcomes and Ocular Safety of Subretinal AAV-RPGR Gene Therapy for RPGR-Associated X-Linked Retinitis Pigmentosa: A Systematic Review and Meta-Analysis.J Clin Med202642652548PubTator, text miningPubMed
Genetic Insights Into Retinitis Pigmentosa: A De Novo RPGR Mutation in an Iranian-Azeri Family.Case Rep Ophthalmol Med202642609816PubTator, text miningPubMed
Efficacy and safety of AAV RPGR gene therapy in X-linked retinitis pigmentosa: a systematic review and meta-analysis.J Transl Med202642576225PubTator, text miningPubMed
Defining a Novel RPGR Phenotype of Sector Retinitis Pigmentosa With Cone Dystrophy.Invest Ophthalmol Vis Sci202642573183PubTator, text miningPubMed
PAX6-associated aniridia and RPGR-related X-linked retinitis pigmentosa: a rare dual Mendelian molecular diagnosis.BMJ Case Rep202642538049PubTator, text miningPubMed
Clinical and Genetic Landscape of RPGR -Associated Retinal Dystrophies in Portugal: Insights From the Nationwide IRD-PT Registry.Clin Exp Ophthalmol202642521440PubTator, text miningPubMed
A novel chimeric RNA RPGR-EEF1A1 enhances autophagy by interaction with the small GTPase RAB37 in a GTP-dependent manner.Genes Dis202642389718PubTator, text miningPubMed

1 to 10 of 1,847

See all 1,847 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6103

GET https://conductscience.org/api/genes/v1/6103/patents?page=2