ConductScience.org, home

Gene · 6118

RPA2: replication protein A2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. RPA2: replication protein A2. Genes, record 6118. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6118

On this page

Gene

Symbol
RPA2
HGNC
Name
replication protein A2
HGNC
NCBI Gene ID
6118
NCBI Gene
HGNC ID
HGNC:10290
HGNC
Ensembl
ENSG00000117748
NCBI Gene
Aliases
REPA2, RP-A p32, RP-A p34, RPA32
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P15927Replication protein A 32 kDa subunit27014Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4791890 A22026-08-19119P15927Espacenet
JP 2026009871 A2026-01-21141P15927Espacenet
JP 2026004568 A2026-01-1461397P15927Espacenet
EP 4650780 A22025-11-199398P15927Espacenet
JP 2025517970 A2025-06-129398P15927Espacenet
US 12281338 B22025-04-2267P15927Espacenet
EP 4464338 A22024-11-20319P15927Espacenet
KR 1020240116572 A2024-07-29141P15927Espacenet
US 11976334 B22024-05-07201P15927Espacenet
US 11932884 B22024-03-19369P15927Espacenet

1 to 10 of 56

See all 56 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,906

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPA2 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines382025
P30CA016672Cancer Center Support Grant302025
P30CA008748Cancer Center Support Grant202025
P30CA068485Cancer Center Support Grant132025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant112025
P30CA016058Cancer Center Support Grant112025
P30CA086862Cancer Center Support Grant102025
R01HL052725Molecular Pathogenesis of Fanconi Anemia102025
T32CA009582Biochemical and Chemical Training for Cancer Research102025
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs102025

1 to 10 of 1,906Source NIH's project files

See all 1,906 nih grants

Papers2,490

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
BUB1 and CDK4/6 Dual Inhibition Increases Radiation Sensitivity in Glioblastoma, Lung Cancer, and Triple-Negative Breast Cancer.Biomedicines202642792682PubTator, text miningPubMed
Nanoparticle Co-delivery of Microtubule Inhibitors and Cisplatin Overcomes DNA Repair-Mediated Resistance in Head and Neck Cancer.Mol Cancer Ther202642777141PubTator, text miningPubMed
The KEAP1-NFE2L2/NRF2 Axis in Non-Small Cell Lung Cancer Radioresistance: Redox Homeostasis and Emerging DNA Damage Response Mechanisms.Cancer Manag Res202642708106PubTator, text miningPubMed
Corrigendum to "CSDE1 enhances genotoxic drug resistance in cancer by modulating RPA2 through the CSDE1-eIF3a regulatory complex" [Drug Resist. Updat. 81 (2025) 101249].Drug Resist Updat202642632763PubTator, text miningPubMed
The tumor suppressor menin is a key scaffold mediator for homologous recombination repair.Nucleic Acids Res202642578372PubTator, text miningPubMed
Fission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination.bioRxiv202642539071PubTator, text miningPubMed
EFHD2 drives lactate-mediated DNA damage repair and immunosuppression via HMGB1 and HIF-1α to confer radioresistance in colorectal cancer.Cell Death Dis202642336814PubTator, text miningPubMed
TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells.Nat Cell Biol202642277434PubTator, text miningPubMed
A RHNO1-ATR/Chk1 positive feedback loop sustains the DNA replication stress response.bioRxiv202642239230PubTator, text miningPubMed
Combination of CHK1 and CHK2 inhibitors exerts synergistic antitumor effects against neuroblastoma cells.Pediatr Res202642230907PubTator, text miningPubMed

1 to 10 of 2,490

See all 2,490 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6118

GET https://conductscience.org/api/genes/v1/6118/patents?page=2