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BCR: BCR activator of RhoGEF and GTPase

1 protein, 41 patents, 15 drugs, 1,131 trials, 6,710 NIH grants and 17,806 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolBCRHGNC
NameBCR activator of RhoGEF and GTPaseHGNC
NCBI Gene ID613NCBI Gene
HGNC IDHGNC:1014HGNC
EnsemblENSG00000186716NCBI Gene
AliasesALL, BCR1, CML, D22S11, D22S662, PHLNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P11274Breakpoint cluster region protein1,2715Ensembl, GeneID, HGNCUniProt

Patents 41

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194217P11274Espacenet
EP 4641201 A22025-10-293774P11274Espacenet
JP 2025147176 A2025-10-0616578P11274Espacenet
EP 4623078 A12025-10-01227P11274Espacenet
JP 2025524002 A2025-07-252P11274Espacenet
JP 2025517969 A2025-06-123774P11274Espacenet
JP 2025517970 A2025-06-124217P11274Espacenet
JP 2025062604 A2025-04-149549P11274Espacenet
KR 1020250039465 A2025-03-202P11274Espacenet
JP 2025028160 A2025-02-2816578P11274Espacenet

Drugs 15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASCIMINIBCHEMBL4208229Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
ASCIMINIB HYDROCHLORIDECHEMBL4297220Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
BOSUTINIBCHEMBL288441Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
BOSUTINIB MONOHYDRATECHEMBL2095206Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
DASATINIBCHEMBL5416410Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
DASATINIB ANHYDROUSCHEMBL1421Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
IMATINIBCHEMBL941Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
IMATINIB MESYLATECHEMBL1642Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
NILOTINIBCHEMBL255863Bcr/Abl fusion protein inhibitorINHIBITORChEMBL
NILOTINIB HYDROCHLORIDE MONOHYDRATECHEMBL1201740Bcr/Abl fusion protein inhibitorINHIBITORChEMBL

Trials 1131

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604233ASCIMINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07559370IMATINIBPHASE2ClinicalTrials.gov
NCT07538401ASCIMINIBPHASE2ClinicalTrials.gov
NCT07538401DASATINIBPHASE2ClinicalTrials.gov
NCT07530367IMATINIBPHASE3ClinicalTrials.gov
NCT07493408NILOTINIBPHASE2ClinicalTrials.gov
NCT07493408ASCIMINIBPHASE2ClinicalTrials.gov
NCT07493408DASATINIBPHASE2ClinicalTrials.gov
NCT07493408IMATINIBPHASE2ClinicalTrials.gov
NCT07493161OLVEREMBATINIBClinicalTrials.gov

NIH grants 6710

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2562,025NIH's project files
P30CA008748Cancer Center Support Grant842,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)802,025NIH's project files
P30CA016058Cancer Center Support Grant352,025NIH's project files
R01CA157644Central tolerance mechanisms in B-cell malignancies272,025NIH's project files
ZIAAI000898B Cell Biology262,025NIH's project files
P30CA042014Cancer Center Support Grant232,025NIH's project files
P30CA006973Regional Oncology Research Center222,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias192,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro192,025NIH's project files

Papers 17806

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825208PubTator, text miningPubMed
42818511PubTator, text miningPubMed
42817982PubTator, text miningPubMed
42817838PubTator, text miningPubMed
42812204PubTator, text miningPubMed
42800522PubTator, text miningPubMed
42794727PubTator, text miningPubMed
42790039PubTator, text miningPubMed
42787611PubTator, text miningPubMed
42784465PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license