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Gene · 6136

RPL12: ribosomal protein L12

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPL12: ribosomal protein L12. Genes, record 6136. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6136

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Gene

Symbol
RPL12
HGNC
Name
ribosomal protein L12
HGNC
NCBI Gene ID
6136
NCBI Gene
HGNC ID
HGNC:10302
HGNC
Ensembl
ENSG00000197958
NCBI Gene
Aliases
L12, uL11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30050Large ribosomal subunit protein uL1116595Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461975P30050Espacenet
EP 4650780 A22025-11-197936P30050Espacenet
EP 4641202 A22025-10-295343P30050Espacenet
JP 2025517970 A2025-06-127936P30050Espacenet
KR 1020250017231 A2025-02-045343P30050Espacenet
US 11860162 B22024-01-021435P30050Espacenet
US 11446398 B22022-09-2073932P30050Espacenet
JP 2022524081 A2022-04-27176903P30050Espacenet
US 11078247 B22021-08-039745P30050Espacenet
US 10746735 B22020-08-181435P30050Espacenet

1 to 10 of 42

See all 42 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATALURENCHEMBL25699780S Ribosome modulatorMODULATORChEMBL
CITATUZUMAB BOGATOXCHEMBL174300080S Ribosome inhibitorINHIBITORChEMBL
CYCLOHEXIMIDECHEMBL12329280S Ribosome inhibitorINHIBITORChEMBL
DORLIMOMAB ARITOXCHEMBL210912480S Ribosome inhibitorINHIBITORChEMBL
ELX-02CHEMBL429774480S Ribosome modulatorMODULATORChEMBL
MT-3724CHEMBL429778980S Ribosome inhibitorINHIBITORChEMBL
TAPLITUMOMAB PAPTOXCHEMBL210789080S Ribosome inhibitorINHIBITORChEMBL
TELIMOMAB ARITOXCHEMBL210879080S Ribosome inhibitorINHIBITORChEMBL
ZOLIMOMAB ARITOXCHEMBL210878580S Ribosome inhibitorINHIBITORChEMBL

Trials38

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07523581ELX-02PHASE2ClinicalTrials.gov
NCT05448755ELX-02PHASE22026-02-24ClinicalTrials.gov
NCT04336826ATALURENPHASE22024-04-01ClinicalTrials.gov
NCT04135495ELX-02PHASE2ClinicalTrials.gov
NCT04126473ELX-02PHASE2ClinicalTrials.gov
NCT04117880ATALURENPHASE2ClinicalTrials.gov
NCT04069260ELX-02PHASE2ClinicalTrials.gov
NCT04014530ATALURENPHASE1/PHASE2ClinicalTrials.gov
NCT03796637ATALURENPHASE22022-04-05ClinicalTrials.gov
NCT03645395MT-3724PHASE22022-08-16ClinicalTrials.gov

1 to 10 of 38

See all 38 trials

NIH grants737

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPL12 papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30AI027763UCSF-Bay Area Center for AIDS Research32025
P30CA016086Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025
T32AR050942Training Program in Adult and Pediatric Rheumatology32025
P01CA092584Structural Cell Biology of DNA Repair Machines22025
P30CA014520UW Comprehensive Cancer Center Support22025
P30CA016672Cancer Center Support Grant22025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202822025
P30CA054174Mays Cancer Center at UT Health SA22025

1 to 10 of 737Source NIH's project files

See all 737 nih grants

Papers1,060

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
IGF2BP3 promotes esophageal squamous cell carcinoma progression by regulating global protein translation.Biochim Biophys Acta Mol Basis Dis202742603622PubTator, text miningPubMed
MYC-Dependent rRNA Catabolism Stress Dictates Survival Heterogeneity of Hepatocellular Carcinoma Cells Under Glutamine Deprivation.Cancer Res202642809776PubTator, text miningPubMed
A strong and ductile Super Kovar alloy via fully coherent nanoprecipitates.Sci Adv202642664320PubTator, text miningPubMed
Single-cell foundation models identify shared and divergent transcriptomic signatures of aging across invertebrates and mammals.bioRxiv202642619888PubTator, text miningPubMed
Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.Biophys J202642381291PubTator, text miningPubMed
Corrigendum to "Mitochondrial ribosomal protein L12 potentiates hepatocellular carcinoma by regulating mitochondrial biogenesis and metabolic reprogramming" [Metabolism. 2024 Mar; 152: 155761. doi:10.1016/j.metabol.2023.155761].
Metabolism202642250458PubTator, text miningPubMed
Identification of a conserved receptor for degrading ribosomes through autophagy.Autophagy202642148801PubTator, text miningPubMed
A single cell transcriptional profile of benign prostatic hyperplasia.Sci Rep202641832222PubTator, text miningPubMed
Decoding the role of RPL38 in lung adenocarcinoma: a multi-omics approach.Front Immunol202641766901PubTator, text miningPubMed
Reversing Mitochondrial Dysfunction in Optineurin E50K Glaucoma: A Metabolic Approach to Neuroprotection.Res Sq202641756461PubTator, text miningPubMed

1 to 10 of 1,060

See all 1,060 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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