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Gene · 6139

RPL17: ribosomal protein L17

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPL17: ribosomal protein L17. Genes, record 6139. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6139

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Gene

Symbol
RPL17
HGNC
Name
ribosomal protein L17
HGNC
NCBI Gene ID
6139
NCBI Gene
HGNC ID
HGNC:10307
HGNC
Ensembl
ENSG00000265681
NCBI Gene
Aliases
DBA22, L17, PD-1, RPL23, rpL23, uL22
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18621Large ribosomal subunit protein uL22184178Ensembl, GeneID, HGNC

Source UniProt

Patents101

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461992P18621Espacenet
JP 2026004568 A2026-01-1461993P18621Espacenet
EP 4650780 A22025-11-1917415P18621Espacenet
EP 4641202 A22025-10-298803P18621Espacenet
JP 2025517970 A2025-06-1217415P18621Espacenet
JP 2025024198 A2025-02-1915585P18621Espacenet
KR 1020250017231 A2025-02-048803P18621Espacenet
US 12006548 B22024-06-11483P18621Espacenet
US 11446398 B22022-09-2073963P18621Espacenet
US 11446398 B22022-09-2073965P18621Espacenet

1 to 10 of 101

See all 101 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATALURENCHEMBL25699780S Ribosome modulatorMODULATORChEMBL
CITATUZUMAB BOGATOXCHEMBL174300080S Ribosome inhibitorINHIBITORChEMBL
CYCLOHEXIMIDECHEMBL12329280S Ribosome inhibitorINHIBITORChEMBL
DORLIMOMAB ARITOXCHEMBL210912480S Ribosome inhibitorINHIBITORChEMBL
ELX-02CHEMBL429774480S Ribosome modulatorMODULATORChEMBL
MT-3724CHEMBL429778980S Ribosome inhibitorINHIBITORChEMBL
TAPLITUMOMAB PAPTOXCHEMBL210789080S Ribosome inhibitorINHIBITORChEMBL
TELIMOMAB ARITOXCHEMBL210879080S Ribosome inhibitorINHIBITORChEMBL
ZOLIMOMAB ARITOXCHEMBL210878580S Ribosome inhibitorINHIBITORChEMBL

Trials38

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07523581ELX-02PHASE2ClinicalTrials.gov
NCT05448755ELX-02PHASE22026-02-24ClinicalTrials.gov
NCT04336826ATALURENPHASE22024-04-01ClinicalTrials.gov
NCT04135495ELX-02PHASE2ClinicalTrials.gov
NCT04126473ELX-02PHASE2ClinicalTrials.gov
NCT04117880ATALURENPHASE2ClinicalTrials.gov
NCT04069260ELX-02PHASE2ClinicalTrials.gov
NCT04014530ATALURENPHASE1/PHASE2ClinicalTrials.gov
NCT03796637ATALURENPHASE22022-04-05ClinicalTrials.gov
NCT03645395MT-3724PHASE22022-08-16ClinicalTrials.gov

1 to 10 of 38

See all 38 trials

NIH grants1,763

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPL17 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA047904Cancer Center Support Grant62025
P51OD011132Emory National Primate Research Center62025
P30CA008748Cancer Center Support Grant52025
P30CA010815Consolidated Basic Cancer Research Program52025
P30CA016086Cancer Center Support Grant52025
P30CA016087Cancer Center Support Grant52025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA015704Cancer Center Support Grant42025

1 to 10 of 1,763Source NIH's project files

See all 1,763 nih grants

Papers2,197

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
IGF2BP3 promotes esophageal squamous cell carcinoma progression by regulating global protein translation.Biochim Biophys Acta Mol Basis Dis202742603622PubTator, text miningPubMed
Macrophage Differentiation Selectively Downregulates RPS15A While Preserving RPL13A and RPL17 Expression in THP-1-Derived Macrophages.J Cardiovasc Dev Dis202642783057PubTator, text miningPubMed
Peripheral Th17 Immune Signature Associates with Excellent Response to Anti-PD-1/Anti-PD-L1 Therapy across Solid Tumors.Cancer Immunol Res202642360819PubTator, text miningPubMed
Ventilation-Associated Differences in Lower Airway Microbial Signatures and Peripheral Blood Transcriptome Among Critically Ill COVID-19 Patients.Infect Drug Resist202642293984PubTator, text miningPubMed
Synergistic antitumor and immunomodulatory effects of Bifidobacterium animalis subsp. lactis V9 combined with anti-PD-1 therapy.Front Immunol202642273689PubTator, text miningPubMed
Endothelial cell RpL17-dependent translational control mediates intima-media thickening in response to disturbed flow.bioRxiv202642244526PubTator, text miningPubMed
TB risk during treatment with biological agents and Janus kinase inhibitors: an umbrella review.Int J Tuberc Lung Dis202642226371PubTator, text miningPubMed
Targeting IL-17 family cytokines and receptors in hepatocellular carcinoma: From biology to combination immunotherapy.Biochim Biophys Acta Rev Cancer202642214769PubTator, text miningPubMed
ZDHHC17-Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance.Adv Sci (Weinh)202642133178PubTator, text miningPubMed
Demethylase ALKBH4 Inhibits Cell Proliferation via Induction of 5'-tsRNAGlu in Non-Small Cell Lung Cancer.Front Biosci (Landmark Ed)202642052838PubTator, text miningPubMed

1 to 10 of 2,197

See all 2,197 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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