ConductScience.org, home

Gene · 6144

RPL21: ribosomal protein L21

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. RPL21: ribosomal protein L21. Genes, record 6144. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6144

On this page

Gene

Symbol
RPL21
HGNC
Name
ribosomal protein L21
HGNC
NCBI Gene ID
6144
NCBI Gene
HGNC ID
HGNC:10313
HGNC
Ensembl
ENSG00000122026
NCBI Gene
Aliases
DKFZp686C06101, FLJ27458, HYPT12, L21, MGC104274, MGC104275, MGC71252, eL21
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P46778Large ribosomal subunit protein eL21160177Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462001P46778Espacenet
JP 2026004568 A2026-01-1462002P46778Espacenet
JP 2026004568 A2026-01-1462003P46778Espacenet
JP 2026004568 A2026-01-1462004P46778Espacenet
EP 4641201 A22025-10-296908P46778Espacenet
JP 2025517969 A2025-06-126908P46778Espacenet
US 11446398 B22022-09-2073996P46778Espacenet
US 11446398 B22022-09-2073997P46778Espacenet
US 11446398 B22022-09-2073998P46778Espacenet
US 11446398 B22022-09-2073999P46778Espacenet

1 to 10 of 45

See all 45 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATALURENCHEMBL25699780S Ribosome modulatorMODULATORChEMBL
CITATUZUMAB BOGATOXCHEMBL174300080S Ribosome inhibitorINHIBITORChEMBL
CYCLOHEXIMIDECHEMBL12329280S Ribosome inhibitorINHIBITORChEMBL
DORLIMOMAB ARITOXCHEMBL210912480S Ribosome inhibitorINHIBITORChEMBL
ELX-02CHEMBL429774480S Ribosome modulatorMODULATORChEMBL
MT-3724CHEMBL429778980S Ribosome inhibitorINHIBITORChEMBL
TAPLITUMOMAB PAPTOXCHEMBL210789080S Ribosome inhibitorINHIBITORChEMBL
TELIMOMAB ARITOXCHEMBL210879080S Ribosome inhibitorINHIBITORChEMBL
ZOLIMOMAB ARITOXCHEMBL210878580S Ribosome inhibitorINHIBITORChEMBL

Trials38

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07523581ELX-02PHASE2ClinicalTrials.gov
NCT05448755ELX-02PHASE22026-02-24ClinicalTrials.gov
NCT04336826ATALURENPHASE22024-04-01ClinicalTrials.gov
NCT04135495ELX-02PHASE2ClinicalTrials.gov
NCT04126473ELX-02PHASE2ClinicalTrials.gov
NCT04117880ATALURENPHASE2ClinicalTrials.gov
NCT04069260ELX-02PHASE2ClinicalTrials.gov
NCT04014530ATALURENPHASE1/PHASE2ClinicalTrials.gov
NCT03796637ATALURENPHASE22022-04-05ClinicalTrials.gov
NCT03645395MT-3724PHASE22022-08-16ClinicalTrials.gov

1 to 10 of 38

See all 38 trials

NIH grants500

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPL21 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines22025
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.22025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA016042Cancer Center Support Grant22025
P30CA054174Mays Cancer Center at UT Health SA22025
P30CA124435Stanford Cancer Institute22025
P30DK020572Michigan Diabetes Research Center (MDRC)22025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control22025
R01HD086634Specialized Translational Control of Stem Cell Differentiation and Embryonic Development22025
ZIAAG000393Influence of Post-transcriptional Gene Regulation on Cell Senescence and Aging22025

1 to 10 of 500Source NIH's project files

See all 500 nih grants

Papers644

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-omics Mendelian randomization identifies mitochondrial genes associated with immune microenvironment signatures in endometriosis.Front Reprod Health202642157969PubTator, text miningPubMed
Identification of ribosomal protein eL21 as a novel externalized protein and a target in triple-negative breast cancer.Cancer Gene Ther202641957522PubTator, text miningPubMed
Aerobic sister lineage of breviates has gene-rich mitochondrial genomes.Curr Biol202641831440PubTator, text miningPubMed
Single-cell spatial transcriptomics uncovers niches that govern response to PD-1/PD-L1 blockade in cutaneous squamous cell carcinoma.J Immunother Cancer202641617396PubTator, text miningPubMed
Integrative Analysis of the Role of MRPL21 in Human Pan-Cancer and Its Relationship with the Progression of Lung Adenocarcinoma.Mol Biotechnol202639775548PubTator, text miningPubMed
Multi-omics identification of immune-related biomarkers predicting tofacitinib response in rheumatoid arthritis.Front Immunol202541668767PubTator, text miningPubMed
LTO1 and YAE1 regulate MHC-I expression via nonsense-mediated RNA decay in tumor cells.J Immunother Cancer202540987494PubTator, text miningPubMed
Triglycerides and T Cells in Cardiovascular Risk: Inflammatory Transcriptomic Profile in Hypertriglyceridemia Patients' T Cells.JACC Basic Transl Sci202540845480PubTator, text miningPubMed
Identifying Molecular Modulators of the Vascular Invasion in Rectal Carcinoma: Role of ADAMTS8 and Its Co-Dependent Genes.Int J Mol Sci202540650042PubTator, text miningPubMed
adverSCarial: assessing the vulnerability of single-cell RNA-sequencing classifiers to adversarial attacks.Bioinformatics202540234247PubTator, text miningPubMed

1 to 10 of 644

See all 644 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6144

GET https://conductscience.org/api/genes/v1/6144/patents?page=2