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Gene · 6146

RPL22: ribosomal protein L22

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPL22: ribosomal protein L22. Genes, record 6146. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6146

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Gene

Symbol
RPL22
HGNC
Name
ribosomal protein L22
HGNC
NCBI Gene ID
6146
NCBI Gene
HGNC ID
HGNC:10315
HGNC
Ensembl
ENSG00000116251
NCBI Gene
Aliases
EAP, HBP15, HBP15/L22, L22, eL22
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35268Large ribosomal subunit protein eL22128142Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462005P35268Espacenet
EP 4650780 A22025-11-197031P35268Espacenet
EP 4641201 A22025-10-296912P35268Espacenet
EP 4641202 A22025-10-295215P35268Espacenet
JP 2025517969 A2025-06-126912P35268Espacenet
JP 2025517970 A2025-06-127031P35268Espacenet
KR 1020250017231 A2025-02-045215P35268Espacenet
US 11884978 B22024-01-30717P35268Espacenet
JP 2024009871 A2024-01-2377P35268Espacenet
US 11446398 B22022-09-2074003P35268Espacenet

1 to 10 of 44

See all 44 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATALURENCHEMBL25699780S Ribosome modulatorMODULATORChEMBL
CITATUZUMAB BOGATOXCHEMBL174300080S Ribosome inhibitorINHIBITORChEMBL
CYCLOHEXIMIDECHEMBL12329280S Ribosome inhibitorINHIBITORChEMBL
DORLIMOMAB ARITOXCHEMBL210912480S Ribosome inhibitorINHIBITORChEMBL
ELX-02CHEMBL429774480S Ribosome modulatorMODULATORChEMBL
MT-3724CHEMBL429778980S Ribosome inhibitorINHIBITORChEMBL
TAPLITUMOMAB PAPTOXCHEMBL210789080S Ribosome inhibitorINHIBITORChEMBL
TELIMOMAB ARITOXCHEMBL210879080S Ribosome inhibitorINHIBITORChEMBL
ZOLIMOMAB ARITOXCHEMBL210878580S Ribosome inhibitorINHIBITORChEMBL

Trials38

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07523581ELX-02PHASE2ClinicalTrials.gov
NCT05448755ELX-02PHASE22026-02-24ClinicalTrials.gov
NCT04336826ATALURENPHASE22024-04-01ClinicalTrials.gov
NCT04135495ELX-02PHASE2ClinicalTrials.gov
NCT04126473ELX-02PHASE2ClinicalTrials.gov
NCT04117880ATALURENPHASE2ClinicalTrials.gov
NCT04069260ELX-02PHASE2ClinicalTrials.gov
NCT04014530ATALURENPHASE1/PHASE2ClinicalTrials.gov
NCT03796637ATALURENPHASE22022-04-05ClinicalTrials.gov
NCT03645395MT-3724PHASE22022-08-16ClinicalTrials.gov

1 to 10 of 38

See all 38 trials

NIH grants1,144

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPL22 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30DK050306Center for Molecular Studies in Digestive and Liver Diseases62025
P30CA016672Cancer Center Support Grant52025
P30CA016086Cancer Center Support Grant42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025
UL1TR001863Yale Clinical and Translational Science Award42025
ZIAHG200338Molecular Analyses of Endometrial Cancer42025
P01CA092584Structural Cell Biology of DNA Repair Machines32025
P30CA072720Cancer Center Support Grant32025

1 to 10 of 1,144Source NIH's project files

See all 1,144 nih grants

Papers1,572

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Translational control by RPL22L1-specific ribosomes enhances DNA repair and chemoresistance.Nat Commun202642680749PubTator, text miningPubMed
Endothelial DANCR deficiency promotes atherosclerotic plaque instability by targeting ribosomal protein L22.J Adv Res202642668039PubTator, text miningPubMed
BAG6-RNF115 Couples Protein Quality Control with Ribosome Assembly.bioRxiv202642620044PubTator, text miningPubMed
Phylogenomic discordance among plastid genes in endangered Maltese Limonium.Sci Rep202642288520PubTator, text miningPubMed
A RiboCancer cell line panel reveals that CLL-associated Rps15 mutations translationally rewire transcription through codon-specific tRNA accommodation defects.Hemasphere202642255948PubTator, text miningPubMed
Loss of ribosomal protein RPL22 restricts African swine fever virus replication by inducing PERK-dependent ER stress.Emerg Microbes Infect202642175753PubTator, text miningPubMed
Anatomy and the chloroplast genome of Bischofia plants reveal important phylogenetic relationship and the genetic diversity in phyllanthaceae.Sci Rep202642128939PubTator, text miningPubMed
Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma.Nat Commun202641792125PubTator, text miningPubMed
Nucleolus as a cornerstone linking proliferation and metabolism to cellular responses to stress: involvement of transcription factors MYC and p53.Front Mol Biosci202641777667PubTator, text miningPubMed
Integrative Spatial Transcriptomics and Immunoinformatics for Prognostic Multi-Epitope Vaccine Construct Prediction Against Synovial Sarcoma.Pharmaceuticals (Basel)202641754822PubTator, text miningPubMed

1 to 10 of 1,572

See all 1,572 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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