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Gene · 6155

RPL27: ribosomal protein L27

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPL27: ribosomal protein L27. Genes, record 6155. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6155

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Gene

Symbol
RPL27
HGNC
Name
ribosomal protein L27
HGNC
NCBI Gene ID
6155
NCBI Gene
HGNC ID
HGNC:10328
HGNC
Ensembl
ENSG00000131469
NCBI Gene
Aliases
DBA16, L27, eL27
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61353Large ribosomal subunit protein eL27136164Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462017P61353Espacenet
EP 4650780 A22025-11-191469P61353Espacenet
EP 4641202 A22025-10-294466P61353Espacenet
JP 2025517970 A2025-06-121469P61353Espacenet
KR 1020250017231 A2025-02-044466P61353Espacenet
JP 2024009871 A2024-01-2343P61353Espacenet
US 11446398 B22022-09-2074048P61353Espacenet
US 11446398 B22022-09-2074049P61353Espacenet
US 11446398 B22022-09-2074051P61353Espacenet
JP 2022524081 A2022-04-27177019P61353Espacenet

1 to 10 of 36

See all 36 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATALURENCHEMBL25699780S Ribosome modulatorMODULATORChEMBL
CITATUZUMAB BOGATOXCHEMBL174300080S Ribosome inhibitorINHIBITORChEMBL
CYCLOHEXIMIDECHEMBL12329280S Ribosome inhibitorINHIBITORChEMBL
DORLIMOMAB ARITOXCHEMBL210912480S Ribosome inhibitorINHIBITORChEMBL
ELX-02CHEMBL429774480S Ribosome modulatorMODULATORChEMBL
MT-3724CHEMBL429778980S Ribosome inhibitorINHIBITORChEMBL
TAPLITUMOMAB PAPTOXCHEMBL210789080S Ribosome inhibitorINHIBITORChEMBL
TELIMOMAB ARITOXCHEMBL210879080S Ribosome inhibitorINHIBITORChEMBL
ZOLIMOMAB ARITOXCHEMBL210878580S Ribosome inhibitorINHIBITORChEMBL

Trials38

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07523581ELX-02PHASE2ClinicalTrials.gov
NCT05448755ELX-02PHASE22026-02-24ClinicalTrials.gov
NCT04336826ATALURENPHASE22024-04-01ClinicalTrials.gov
NCT04135495ELX-02PHASE2ClinicalTrials.gov
NCT04126473ELX-02PHASE2ClinicalTrials.gov
NCT04117880ATALURENPHASE2ClinicalTrials.gov
NCT04069260ELX-02PHASE2ClinicalTrials.gov
NCT04014530ATALURENPHASE1/PHASE2ClinicalTrials.gov
NCT03796637ATALURENPHASE22022-04-05ClinicalTrials.gov
NCT03645395MT-3724PHASE22022-08-16ClinicalTrials.gov

1 to 10 of 38

See all 38 trials

NIH grants889

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPL27 papersNewest fiscal year
P30CA008748Cancer Center Support Grant142025
P30AI036214San Diego Center for AIDS Research (SD CFAR)72025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center72025
R01AR045203D4Z4 Coding Transcripts and FSHD72025
P30CA016086Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
P30CA015704Cancer Center Support Grant52025
P30EY007551Center Core Grant for Vision Research42025
T32HG000035Interdisciplinary Training in Genome Sciences42025
P30AI027763UCSF-Bay Area Center for AIDS Research32025

1 to 10 of 889Source NIH's project files

See all 889 nih grants

Papers1,010

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single-cell transcriptomics combined with Mendelian randomization reveals the pivotal role of WDR83OS in clear cell renal cell carcinoma: An observational and bioinformatic study.Medicine (Baltimore)202642760660PubTator, text miningPubMed
Reference Genes for Expression Analyses by RT-qPCR in Hyblaea puera (Lepidoptera: Hyblaeidae).Insects202642355372PubTator, text miningPubMed
Selection of reference genes for normalization of quantitative real-time polymerase chain reaction analysis in foxglove aphid (Hemiptera: Aphididae).J Econ Entomol202642161856PubTator, text miningPubMed
Global molecular landscape of early MASLD progression in human obesity.Elife202641870035PubTator, text miningPubMed
Identification of hub genes and signaling pathways as possible therapeutic targets in human glioblastoma: evidenced by bioinformatics analysis.Brain Res202641478499PubTator, text miningPubMed
Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy.Acta Neuropathol Commun202540993824PubTator, text miningPubMed
Intron retention: a novel method for evaluating the response to ketamine in patients with treatment-resistant depression.Npj Ment Health Res202540946107PubTator, text miningPubMed
Characterization of ribosome heterogeneity during endothelial to hematopoietic transition.FEBS Open Bio202540588840PubTator, text miningPubMed
Identification of robust RT-qPCR reference genes for studying changes in gene expression in response to hypoxia in breast cancer cell lines.BMC Genomics202539838295PubTator, text miningPubMed
Identification of Genes Associated with Familial Focal Segmental Glomerulosclerosis Through Transcriptomics and In Silico Analysis, Including RPL27, TUBB6, and PFDN5.Int J Mol Sci202439519211PubTator, text miningPubMed

1 to 10 of 1,010

See all 1,010 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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