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Gene · 6195

RPS6KA1: ribosomal protein S6 kinase A1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPS6KA1: ribosomal protein S6 kinase A1. Genes, record 6195. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6195

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Gene

Symbol
RPS6KA1
HGNC
Name
ribosomal protein S6 kinase A1
HGNC
NCBI Gene ID
6195
NCBI Gene
HGNC ID
HGNC:10430
HGNC
Ensembl
ENSG00000117676
NCBI Gene
Aliases
HU-1, MAPKAPK1, MAPKAPK1A, RSK, RSK1, p90Rsk
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15418Ribosomal protein S6 kinase alpha-173523Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025032204 A2025-03-1135029Q15418Espacenet
JP 2025032204 A2025-03-1135041Q15418Espacenet
EP 4461818 A22024-11-1335029Q15418Espacenet
EP 4461818 A22024-11-1335041Q15418Espacenet
JP 2024123008 A2024-09-108236Q15418Espacenet
US 11884978 B22024-01-30718Q15418Espacenet
JP 2023123507 A2023-09-0545Q15418Espacenet
US 11708396 B22023-07-251827Q15418Espacenet
JP 2023058610 A2023-04-2535029Q15418Espacenet
JP 2023058610 A2023-04-2535041Q15418Espacenet

1 to 10 of 47

See all 47 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
TAS0612CHEMBL4650277p90RSK inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,723

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPS6KA1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant602025
P30CA008748Cancer Center Support Grant182025
R01CA046595Mitogenic and Oncogenic Regulation of ERK/RSK Signaling182025
P30CA068485Cancer Center Support Grant102025
P30CA076292Moffitt Cancer Center Support Grant102025
P30CA010815Consolidated Basic Cancer Research Program82025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center82025
P30CA016086Cancer Center Support Grant72025
P30CA044579University of Virginia Cancer Center Support Grant72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025

1 to 10 of 2,723Source NIH's project files

See all 2,723 nih grants

Papers3,575

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genome-wide transcriptomics and a machine learning-based random forest model identify novel biomarkers to predict phenotypic variability in Wilson disease.Hum Immunol202642826579PubTator, text miningPubMed
A functional prognostic model predicts progression-free survival in patients with relapsed chronic lymphocytic leukemia treated with ibrutinib + venetoclax.Hemasphere202642757031PubTator, text miningPubMed
USP5 stabilizes RSK1 and promotes temozolomide resistance in glioblastoma.Biochem Biophys Res Commun202642636771PubTator, text miningPubMed
Comprehensive profiling of OTSSP167 action in adrenocortical carcinoma.Endocrinology202642601067PubTator, text miningPubMed
Nuclear RSK1 mediates interferon-γ-induced proinflammatory activation in human primary macrophages and humanized mice.Sci Adv202642600004PubTator, text miningPubMed
Deciphering protein mutation-phenotype linkages from CRISPR-based tiling mutagenesis screens.Cell Syst202642361799PubTator, text miningPubMed
Podoplanin Antibody SZ168 Alleviates Sepsis Inflammation and Macrophage Dysregulation via ERK Signaling.Hum Mutat202642272990PubTator, text miningPubMed
Emodin inhibits Newcastle disease virus replication via regulating the phosphorylation levels of eEF2K/eEF2 and targeting viral N protein to reduce viral protein production.Poult Sci202642241768PubTator, text miningPubMed
The anticancer effects of PCAIs in pancreatic cancer cells involve MAPK and PI3K/AKT pathways hyperactivation.Oncotarget202642233520PubTator, text miningPubMed
Ionizing radiation expands a p90RSK-activated patrolling monocyte subset: modulation by colchicine.Front Cardiovasc Med202642064851PubTator, text miningPubMed

1 to 10 of 3,575

See all 3,575 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6195

GET https://conductscience.org/api/genes/v1/6195/patents?page=2