Gene · 6195
RPS6KA1: ribosomal protein S6 kinase A1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RPS6KA1: ribosomal protein S6 kinase A1. Genes, record 6195. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6195
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15418 | Ribosomal protein S6 kinase alpha-1 | 735 | 23 | Ensembl, GeneID, HGNC |
Source UniProt
Patents47
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025032204 A | 2025-03-11 | 35029 | Q15418 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35041 | Q15418 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 35029 | Q15418 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 35041 | Q15418 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8236 | Q15418 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 718 | Q15418 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 45 | Q15418 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1827 | Q15418 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 35029 | Q15418 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 35041 | Q15418 | Espacenet |
1 to 10 of 47
See all 47 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| TAS0612 | CHEMBL4650277 | p90RSK inhibitor | INHIBITOR |
Source ChEMBL
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,723
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RPS6KA1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 60 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 18 | 2025 |
| R01CA046595 | Mitogenic and Oncogenic Regulation of ERK/RSK Signaling | 18 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 10 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 10 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 8 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 8 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 7 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 7 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 6 | 2025 |
1 to 10 of 2,723Source NIH's project files
See all 2,723 nih grantsPapers3,575
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genome-wide transcriptomics and a machine learning-based random forest model identify novel biomarkers to predict phenotypic variability in Wilson disease. | Hum Immunol | 2026 | 42826579 | PubTator, text mining | PubMed |
| A functional prognostic model predicts progression-free survival in patients with relapsed chronic lymphocytic leukemia treated with ibrutinib + venetoclax. | Hemasphere | 2026 | 42757031 | PubTator, text mining | PubMed |
| USP5 stabilizes RSK1 and promotes temozolomide resistance in glioblastoma. | Biochem Biophys Res Commun | 2026 | 42636771 | PubTator, text mining | PubMed |
| Comprehensive profiling of OTSSP167 action in adrenocortical carcinoma. | Endocrinology | 2026 | 42601067 | PubTator, text mining | PubMed |
| Nuclear RSK1 mediates interferon-γ-induced proinflammatory activation in human primary macrophages and humanized mice. | Sci Adv | 2026 | 42600004 | PubTator, text mining | PubMed |
| Deciphering protein mutation-phenotype linkages from CRISPR-based tiling mutagenesis screens. | Cell Syst | 2026 | 42361799 | PubTator, text mining | PubMed |
| Podoplanin Antibody SZ168 Alleviates Sepsis Inflammation and Macrophage Dysregulation via ERK Signaling. | Hum Mutat | 2026 | 42272990 | PubTator, text mining | PubMed |
| Emodin inhibits Newcastle disease virus replication via regulating the phosphorylation levels of eEF2K/eEF2 and targeting viral N protein to reduce viral protein production. | Poult Sci | 2026 | 42241768 | PubTator, text mining | PubMed |
| The anticancer effects of PCAIs in pancreatic cancer cells involve MAPK and PI3K/AKT pathways hyperactivation. | Oncotarget | 2026 | 42233520 | PubTator, text mining | PubMed |
| Ionizing radiation expands a p90RSK-activated patrolling monocyte subset: modulation by colchicine. | Front Cardiovasc Med | 2026 | 42064851 | PubTator, text mining | PubMed |
1 to 10 of 3,575
See all 3,575 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6195
GET https://conductscience.org/api/genes/v1/6195/patents?page=2