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Gene · 6196

RPS6KA2: ribosomal protein S6 kinase A2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPS6KA2: ribosomal protein S6 kinase A2. Genes, record 6196. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6196

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Gene

Symbol
RPS6KA2
HGNC
Name
ribosomal protein S6 kinase A2
HGNC
NCBI Gene ID
6196
NCBI Gene
HGNC ID
HGNC:10431
HGNC
Ensembl
ENSG00000071242
NCBI Gene
Aliases
HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, p90RSK2, pp90RSK3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15349Ribosomal protein S6 kinase alpha-27330Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12569486 B22026-03-102Q15349Espacenet
JP 2026505638 A2026-02-1610Q15349Espacenet
EP 4665851 A22025-12-2410Q15349Espacenet
JP 2025041721 A2025-03-261Q15349Espacenet
JP 2024123008 A2024-09-108240Q15349Espacenet
US 11944625 B22024-04-022Q15349Espacenet
US 11938198 B22024-03-261Q15349Espacenet
US 11931402 B22024-03-191Q15349Espacenet
US 11446398 B22022-09-2074424Q15349Espacenet
JP 2022532763 A2022-07-1912Q15349Espacenet

1 to 10 of 49

See all 49 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
TAS0612CHEMBL4650277p90RSK inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,170

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPS6KA2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant302025
P30CA008748Cancer Center Support Grant172025
R01CA046595Mitogenic and Oncogenic Regulation of ERK/RSK Signaling122025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes102025
P30CA016086Cancer Center Support Grant82025
P30CA068485Cancer Center Support Grant72025
P30CA056036Translational Research in Cancer62025
T32CA071341Cancer Cell Biology Training Program62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30CA030199Cancer Center Support Grant (CCSG)52025

1 to 10 of 2,170Source NIH's project files

See all 2,170 nih grants

Papers2,567

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MAPK signaling links BRD2 chromatin occupancy to PI3K/AKT inhibitor sensitivity.bioRxiv202642818240PubTator, text miningPubMed
A multi-omics Mendelian randomization study identifies putatively causal genes and pathways for Alzheimer's disease associated with reactive astrocytes.J Alzheimers Dis202642775789PubTator, text miningPubMed
Dual Targeting of FGFR4 and PI3K-mTOR Suppresses Tumor-Associated Phenotypes in Pancreatic Ductal Adenocarcinoma.Int J Mol Sci202642737619PubTator, text miningPubMed
PDK1 signaling in cancer: Current status and future perspectives.Int J Biol Macromol202642716156PubTator, text miningPubMed
Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults.Environ Epigenet202642698993PubTator, text miningPubMed
Genomic insights into stroke recovery: cross-phenotype associations.Brain Commun202642695012PubTator, text miningPubMed
Placental Epigenetic Alterations and IL-10 Dysregulation Drive Early Persistent Food Allergy.Allergy202642618975PubTator, text miningPubMed
Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis.Mol Med Rep202642596822PubTator, text miningPubMed
Integrating dynamic modeling of signaling pathways with subject-specific transcriptomic data to assess breast cancer risk.PLoS One202642594127PubTator, text miningPubMed
EPHA2/CD44-directed trafficking enhances endosomal leakiness and antisense therapy delivery.J Cell Biol202642578958PubTator, text miningPubMed

1 to 10 of 2,567

See all 2,567 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6196

GET https://conductscience.org/api/genes/v1/6196/patents?page=2