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Gene · 6197

RPS6KA3: ribosomal protein S6 kinase A3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPS6KA3: ribosomal protein S6 kinase A3. Genes, record 6197. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6197

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Gene

Symbol
RPS6KA3
HGNC
Name
ribosomal protein S6 kinase A3
HGNC
NCBI Gene ID
6197
NCBI Gene
HGNC ID
HGNC:10432
HGNC
Ensembl
ENSG00000177189
NCBI Gene
Aliases
CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, XLID19, p90-RSK2, pp90RSK2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51812Ribosomal protein S6 kinase alpha-374015Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1910180P51812Espacenet
EP 4641201 A22025-10-2910486P51812Espacenet
JP 2025517969 A2025-06-1210486P51812Espacenet
JP 2025517970 A2025-06-1210180P51812Espacenet
US 11884978 B22024-01-30719P51812Espacenet
US 11446398 B22022-09-2074434P51812Espacenet
JP 2022524081 A2022-04-27177405P51812Espacenet
KR 1020210142125 A2021-11-243P51812Espacenet
US 11078247 B22021-08-039806P51812Espacenet
US 10813931 B22020-10-2734P51812Espacenet

1 to 10 of 36

See all 36 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
TAS0612CHEMBL4650277p90RSK inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,366

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPS6KA3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant202025
R01CA046595Mitogenic and Oncogenic Regulation of ERK/RSK Signaling72025
P30CA044579University of Virginia Cancer Center Support Grant62025
P30CA043703Case Comprehensive Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
P30CA071789University of Hawaii Cancer Center CCSG42025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025
P30CA076292Moffitt Cancer Center Support Grant32025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer32025
R01CA196643Mechanisms of metabolic reprogramming by PIK3CA oncogenic mutations32025

1 to 10 of 1,366Source NIH's project files

See all 1,366 nih grants

Papers2,253

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative phosphoproteomics reveals kinase-mediated regulation of OCIAD1 and its roles in mitochondrial quality control.Front Bioinform202642564255PubTator, text miningPubMed
A patent perspective of RSK inhibitors to treat cancer (2020-present).Expert Opin Ther Pat202642508020PubTator, text miningPubMed
The PDPK1-RSK2 axis as a potential convergent therapeutic vulnerability in B-cell lymphomas.Expert Opin Ther Targets202642489440PubTator, text miningPubMed
Discovery of a New Scaffold RSK2 Inhibitor With Virtual and Phenotypical Screening.ChemMedChem202642363227PubTator, text miningPubMed
Meta-cancer phosphoproteomic analysis unveils association of Tau phosphosites with DNA damage response.Front Syst Biol202642254072PubTator, text miningPubMed
MEK/ERK/RSK2 positive feedback loop modulates EMT to promote migration and invasion of triple-negative breast cancer through regulating GALNT5 mRNA stability.Carcinogenesis202642236296PubTator, text miningPubMed
[Coffin-Lowry syndrome: Case report in Mexico].Rev Med Inst Mex Seguro Soc202642096245PubTator, text miningPubMed
Benzyl-Naphthoquinones as Selective Anticancer Agents for Oral Squamous Cell Carcinoma via Apoptosis Induction.Biomedicines202642072298PubTator, text miningPubMed
RPS6KA3/RSK2-mediated phosphorylation of DRAM2 promotes lysosomal targeting and autophagic flux in melanoma.Autophagy202642059423PubTator, text miningPubMed
Challenges in Diagnosis and Management of Coffin-Lowry Syndrome-Single-Center Experience.Diagnostics (Basel)202641975704PubTator, text miningPubMed

1 to 10 of 2,253

See all 2,253 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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