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RPS6KB1: ribosomal protein S6 kinase B1

1 protein, 54 patents, 5 drugs, 4 trials, 9,452 NIH grants and 21,306 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRPS6KB1HGNC
Nameribosomal protein S6 kinase B1HGNC
NCBI Gene ID6198NCBI Gene
HGNC IDHGNC:10436HGNC
EnsemblENSG00000108443NCBI Gene
AliasesPS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alphaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P23443Ribosomal protein S6 kinase beta-152522Ensembl, GeneID, HGNCUniProt

Patents 54

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19632P23443Espacenet
EP 4641201 A22025-10-29443P23443Espacenet
JP 2025517969 A2025-06-12443P23443Espacenet
JP 2025517970 A2025-06-12632P23443Espacenet
US 12130292 B22024-10-2933P23443Espacenet
JP 2024123008 A2024-09-108230P23443Espacenet
US 11708396 B22023-07-251818P23443Espacenet
US 11446398 B22022-09-2074387P23443Espacenet
JP 2022524081 A2022-04-27177358P23443Espacenet
US 11237173 B22022-02-0133P23443Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LY-2584702CHEMBL3545076Ribosomal protein S6 kinase 1 inhibitorINHIBITORChEMBL
LY-2780301CHEMBL3545134Ribosomal protein S6 kinase (P70S6K) inhibitorINHIBITORChEMBL
RUPITASERTIBCHEMBL4871106Ribosomal protein S6 kinase (P70S6K) inhibitorINHIBITORChEMBL
TAS0612CHEMBL4650277Ribosomal protein S6 kinase (P70S6K) inhibitorINHIBITORChEMBL
XL-418CHEMBL2016893Ribosomal protein S6 kinase (P70S6K) inhibitorINHIBITORChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01980277LY-2780301PHASE1/PHASE2ClinicalTrials.gov
NCT01971515RUPITASERTIBPHASE1ClinicalTrials.gov
NCT01115803LY-2584702PHASE12019-01-18ClinicalTrials.gov
NCT00460278XL-418PHASE1ClinicalTrials.gov

NIH grants 9452

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant3112,025NIH's project files
P30CA008748Cancer Center Support Grant1162,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes732,025NIH's project files
P30AG024832UTMB Claude D. Pepper Older Americans Independence Center352,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)282,025NIH's project files
P30CA016086Cancer Center Support Grant262,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA262,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant262,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program252,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center252,025NIH's project files

Papers 21306

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821034PubTator, text miningPubMed
42817110PubTator, text miningPubMed
42816254PubTator, text miningPubMed
42807832PubTator, text miningPubMed
42785080PubTator, text miningPubMed
42778578PubTator, text miningPubMed
42767540PubTator, text miningPubMed
42736652PubTator, text miningPubMed
42736631PubTator, text miningPubMed
42716156PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license