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Gene · 6222

RPS18: ribosomal protein S18

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPS18: ribosomal protein S18. Genes, record 6222. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6222

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Gene

Symbol
RPS18
HGNC
Name
ribosomal protein S18
HGNC
NCBI Gene ID
6222
NCBI Gene
HGNC ID
HGNC:10401
HGNC
Ensembl
ENSG00000231500
NCBI Gene
Aliases
D6S218E, HKE3, KE-3, KE3, S18, uS13
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P62269Small ribosomal subunit protein uS13152199Ensembl, GeneID, HGNC

Source UniProt

Patents82

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462094P62269Espacenet
JP 2026004568 A2026-01-1462095P62269Espacenet
JP 2026004568 A2026-01-1462096P62269Espacenet
JP 2026004568 A2026-01-1462098P62269Espacenet
JP 2026004568 A2026-01-1462099P62269Espacenet
EP 4650780 A22025-11-1912566P62269Espacenet
EP 4641202 A22025-10-296278P62269Espacenet
JP 2025517970 A2025-06-1212566P62269Espacenet
KR 1020250017231 A2025-02-046278P62269Espacenet
JP 2024009871 A2024-01-2374P62269Espacenet

1 to 10 of 82

See all 82 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATALURENCHEMBL25699780S Ribosome modulatorMODULATORChEMBL
CITATUZUMAB BOGATOXCHEMBL174300080S Ribosome inhibitorINHIBITORChEMBL
CYCLOHEXIMIDECHEMBL12329280S Ribosome inhibitorINHIBITORChEMBL
DORLIMOMAB ARITOXCHEMBL210912480S Ribosome inhibitorINHIBITORChEMBL
ELX-02CHEMBL429774480S Ribosome modulatorMODULATORChEMBL
MT-3724CHEMBL429778980S Ribosome inhibitorINHIBITORChEMBL
TAPLITUMOMAB PAPTOXCHEMBL210789080S Ribosome inhibitorINHIBITORChEMBL
TELIMOMAB ARITOXCHEMBL210879080S Ribosome inhibitorINHIBITORChEMBL
ZOLIMOMAB ARITOXCHEMBL210878580S Ribosome inhibitorINHIBITORChEMBL

Trials38

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07523581ELX-02PHASE2ClinicalTrials.gov
NCT05448755ELX-02PHASE22026-02-24ClinicalTrials.gov
NCT04336826ATALURENPHASE22024-04-01ClinicalTrials.gov
NCT04135495ELX-02PHASE2ClinicalTrials.gov
NCT04126473ELX-02PHASE2ClinicalTrials.gov
NCT04117880ATALURENPHASE2ClinicalTrials.gov
NCT04069260ELX-02PHASE2ClinicalTrials.gov
NCT04014530ATALURENPHASE1/PHASE2ClinicalTrials.gov
NCT03796637ATALURENPHASE22022-04-05ClinicalTrials.gov
NCT03645395MT-3724PHASE22022-08-16ClinicalTrials.gov

1 to 10 of 38

See all 38 trials

NIH grants1,052

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPS18 papersNewest fiscal year
P20GM103427Nebraska Research Network in Functional Genomics82025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant62025
P30ES006694Southwest Environmental Health Sciences Center62025
P30CA013330Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30CA033572Cancer Center Support Grant32025
P30DK034854Integrated Epithelial and Muscosal Biology32025
P30DK065988UNC Cystic Fibrosis Research and Translation Core Center32025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
T32ES007091Training in Environmental Toxicology of Human Disease32025

1 to 10 of 1,052Source NIH's project files

See all 1,052 nih grants

Papers1,497

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The complete chloroplast genome of Indigofera argentea from Saudi Arabia: comparative genomic analysis within the genus Indigofera.Front Plant Sci202642819347PubTator, text miningPubMed
Characterisation of the chloroplast genome of Macrotyloma species: comparative analysis and phylogenomic insights.Sci Rep202642303652PubTator, text miningPubMed
A synergistic multi-omics approach: causal sepsis drivers identified in activated CD4+ T cells by single-cell RNA sequencing and Mendelian randomization.Front Cell Infect Microbiol202642291321PubTator, text miningPubMed
Selection of reference genes for normalization of quantitative real-time polymerase chain reaction analysis in foxglove aphid (Hemiptera: Aphididae).J Econ Entomol202642161856PubTator, text miningPubMed
MoSAIC: Codon Harmonization of Monte Carlo-Based Simulated Annealing for Linked Codons in Heterologous Protein Expression.ACS Synth Biol202642130380PubTator, text miningPubMed
3-Aminoisoquinolines inhibit selectively phosphodiesterase 4B in KRAS-mutated colorectal cancer cell lines in-vitro and in-vivo.Anticancer Drugs202641934673PubTator, text miningPubMed
Association between omeprazole and memory impairment: Insights from NHANES data analysis and network pharmacology studies.J Alzheimers Dis202641879275PubTator, text miningPubMed
Monkeypox virus protein OPG188 antagonizes cGAS-STING antiviral signaling pathway to mediate immune evasion.Proc Natl Acad Sci U S A202641849394PubTator, text miningPubMed
Chloroplast genome comparison of Valeriana species with sequence variation, selective pressure, and divergence analysis.PLoS One202641843567PubTator, text miningPubMed
RSRC2 is a novel RNA-binding protein that safeguards mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1.Nucleic Acids Res202641841495PubTator, text miningPubMed

1 to 10 of 1,497

See all 1,497 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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