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Gene · 623

BDKRB1: bradykinin receptor B1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BDKRB1: bradykinin receptor B1. Genes, record 623. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/623

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Gene

Symbol
BDKRB1
HGNC
Name
bradykinin receptor B1
HGNC
NCBI Gene ID
623
NCBI Gene
HGNC ID
HGNC:1029
HGNC
Ensembl
ENSG00000100739
NCBI Gene
Aliases
B1BKR, B1R, BKB1R, BKR1, BRADYB1, bradyb1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P46663B1 bradykinin receptor3533Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439083P46663Espacenet
EP 4641201 A22025-10-29259P46663Espacenet
JP 2025529142 A2025-09-04573P46663Espacenet
US 12371689 B22025-07-29573P46663Espacenet
JP 2025517969 A2025-06-12259P46663Espacenet
JP 2025062604 A2025-04-149404P46663Espacenet
JP 2025062604 A2025-04-149406P46663Espacenet
US 11732303 B22023-08-2211P46663Espacenet
US 11446398 B22022-09-209404P46663Espacenet
US 11446398 B22022-09-209406P46663Espacenet

1 to 10 of 31

See all 31 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BI113823CHEMBL3545386Bradykinin B1 receptor antagonistANTAGONISTChEMBL
MK0686CHEMBL232943Bradykinin B1 receptor antagonistANTAGONISTChEMBL
SAFOTIBANTCHEMBL1254771Bradykinin B1 receptor antagonistANTAGONISTChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01319487SAFOTIBANTPHASE2ClinicalTrials.gov
NCT01207973BI113823PHASE1ClinicalTrials.gov
NCT00296569MK0686PHASE2ClinicalTrials.gov
NCT00282763MK0686PHASE2ClinicalTrials.gov

NIH grants929

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBDKRB1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant52025
P30DK036836Diabetes Research Center42025
R01HL049277Animal Models for Studying the Genetics of Complex Diseases42025
T32GM007569Clinical Pharmacology Training Program42025
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS42025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center22025
R01AI183620Role of the Hippo pathway in scleroderma pathogenesis22025
R01NS106879Development and Characterization of Small Molecule Activators of Peptidase Neurolysin for Stroke Therapy22025
T32AR007080Scientist Training in Rheumatology Research22025
T32HL007227Pathophysiology of Myocardial Disease22025

1 to 10 of 929Source NIH's project files

See all 929 nih grants

Papers2,473

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Beta-Blockers for the Treatment of Arrhythmias: Which Drug for Which Arrhythmia? A State-of-the-Art Narrative Review.Am J Cardiovasc Drugs202642766102PubTator, text miningPubMed
G protein signaling capabilities at the bradykinin 2 receptor.Naunyn Schmiedebergs Arch Pharmacol202642547588PubTator, text miningPubMed
Therapeutic Targeting of the Bradykinin B2 Receptor in Immunological and Vascular Diseases: Insights from Kinin Biology to Clinical Outcomes.Clin Rev Allergy Immunol202642397484PubTator, text miningPubMed
Survival benefit analysis of beta-blockers in patients with sepsis-induced TnT-positive myocardial injury across different clinical subtypes of sepsis: A retrospective study based on the MIMIC-IV database.
Eur J Pharmacol202642248500PubTator, text miningPubMed
G protein-coupled receptor autoantibody expression patterns in adults with decelerated biological aging mirror pediatric profiles.BMC Immunol202642237231PubTator, text miningPubMed
A human telomerase reverse transcriptase-derived peptide GV1001 rescues neurodegeneration in a mouse model of Alzheimer disease.Exp Mol Med202642236894PubTator, text miningPubMed
Molecular mechanisms for subtype selectivity of kinin receptors' antagonists.Nat Commun202642185275PubTator, text miningPubMed
Kallikrein-8 contributes to kallikrein-kinin system dysregulation in Alzheimer's disease.Exp Neurol202642140379PubTator, text miningPubMed
BDKRB1 Links Copy Number-Defined Genomic Instability to Inflammatory and Immunosuppressive Tumor Ecosystems in Ovarian Cancer: An Integrative Multiomics Analysis.Int J Genomics202642088621PubTator, text miningPubMed
An Immunomodulating Peptide With Potential to Counteract Endometriosis.Aust N Z J Obstet Gynaecol202641913689PubTator, text miningPubMed

1 to 10 of 2,473

See all 2,473 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/623

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