Gene · 6241
RRM2: ribonucleotide reductase regulatory subunit M2
11 sourcesgene-search-2026-11-11-0.1.0
Cite this record
ConductScience Library. RRM2: ribonucleotide reductase regulatory subunit M2. Genes, record 6241. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/6241
On this page
Gene
Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P31350 | Ribonucleoside-diphosphate reductase subunit M2 | 389 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents66
Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 61937 | P31350 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4179 | P31350 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4785 | P31350 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3785 | P31350 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3785 | P31350 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4179 | P31350 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4785 | P31350 | Espacenet |
| US 12208133 B2 | 2025-01-28 | 4 | P31350 | Espacenet |
| EP 4310198 A2 | 2024-01-24 | 36 | P31350 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 73870 | P31350 | Espacenet |
1 to 10 of 66
See all 66 patentsDrugs10
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| CLOFARABINE | CHEMBL1750 | Ribonucleoside-diphosphate reductase RR1 inhibitor | INHIBITOR | ChEMBL |
| FLUDARABINE PHOSPHATE | CHEMBL1096882 | Ribonucleoside-diphosphate reductase RR1 inhibitor | INHIBITOR | ChEMBL |
| GALLIUM NITRATE | CHEMBL1200983 | Ribonucleoside-diphosphate reductase RR1 inhibitor | INHIBITOR | ChEMBL |
| GEMCITABINE | CHEMBL888 | Ribonucleoside-diphosphate reductase RR1 inhibitor | INHIBITOR | ChEMBL |
| GEMCITABINE HYDROCHLORIDE | CHEMBL1637 | Ribonucleoside-diphosphate reductase RR1 inhibitor | INHIBITOR | ChEMBL |
| GTI-2040 | CHEMBL4297763 | Ribonucleotide reductase small subunit mRNA antisense inhibitor | ANTISENSE INHIBITOR | ChEMBL |
| HYDROXYUREA | CHEMBL467 | Ribonucleoside-diphosphate reductase RR1 inhibitor | INHIBITOR | ChEMBL |
| MOTEXAFIN GADOLINIUM | CHEMBL3544910 | Ribonucleoside-diphosphate reductase RR1 inhibitor | INHIBITOR | ChEMBL |
| TEZACITABINE | CHEMBL3989496 | Ribonucleoside-diphosphate reductase RR1 inhibitor | INHIBITOR | ChEMBL |
| TEZACITABINE ANHYDROUS | CHEMBL2105467 | Ribonucleoside-diphosphate reductase RR1 inhibitor | INHIBITOR | ChEMBL |
Trials3,154
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604766 | GEMCITABINE | PHASE3 | ClinicalTrials.gov | |
| NCT07603557 | FLUDARABINE PHOSPHATE | PHASE2 | ClinicalTrials.gov | |
| NCT07602140 | GEMCITABINE | PHASE2 | ClinicalTrials.gov | |
| NCT07598318 | GEMCITABINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07579195 | GEMCITABINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07575191 | GEMCITABINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07570849 | GEMCITABINE | PHASE2 | ClinicalTrials.gov | |
| NCT07570823 | GEMCITABINE | PHASE3 | ClinicalTrials.gov | |
| NCT07570017 | GEMCITABINE | PHASE1 | ClinicalTrials.gov | |
| NCT07569679 | GEMCITABINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 3,154
See all 3,154 trialsNIH grants2,322
NIH projects whose papers are about the gene, through NIH's grant-paper links.
| Project | Title | Its papers about the gene | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 26 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 25 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 12 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 11 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 11 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 10 | 2025 |
| R01GM070503 | Molecular Recognition During Pre-mRNA Splicing | 10 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 9 | 2025 |
| ZIAAG000511 | Post-transcriptional control of Proliferation, Stress Response & Carcinogenesis | 9 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 8 | 2025 |
1 to 10 of 2,322Source NIH's project files
See all 2,322 nih grantsPapers4,414
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| PMID | Found by | Source |
|---|---|---|
| 42821473 | PubTator, text mining | PubMed |
| 42817800 | PubTator, text mining | PubMed |
| 42794427 | PubTator, text mining | PubMed |
| 42732660 | PubTator, text mining | PubMed |
| 42726806 | PubTator, text mining | PubMed |
| 42708612 | PubTator, text mining | PubMed |
| 42703413 | PubTator, text mining | PubMed |
| 42667808 | PubTator, text mining | PubMed |
| 42664521 | PubTator, text mining | PubMed |
| 42661875 | PubTator, text mining | PubMed |
1 to 10 of 4,414
See all 4,414 papersSources 11
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNone stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GeneNone named. Public domain as US government information
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6241
GET https://conductscience.org/api/genes/v1/6241/patents?page=2