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RXRA: retinoid X receptor alpha

1 protein, 95 patents, 8 drugs, 81 trials, 8,435 NIH grants and 15,812 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRXRAHGNC
Nameretinoid X receptor alphaHGNC
NCBI Gene ID6256NCBI Gene
HGNC IDHGNC:10477HGNC
EnsemblENSG00000186350NCBI Gene
AliasesNR2B1, RXR-alpha, RXRalphaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P19793Retinoic acid receptor RXR-alpha462110Ensembl, GeneID, HGNCUniProt

Patents 95

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461534P19793Espacenet
EP 4650780 A22025-11-1914359P19793Espacenet
EP 4641201 A22025-10-2916796P19793Espacenet
JP 2025147176 A2025-10-0615592P19793Espacenet
JP 2025517969 A2025-06-1216796P19793Espacenet
JP 2025517970 A2025-06-1214359P19793Espacenet
US 12280021 B22025-04-2264P19793Espacenet
US 12269793 B22025-04-0864P19793Espacenet
WO 2025059663 A12025-03-2028P19793Espacenet
JP 2025038035 A2025-03-184339P19793Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACITRETINCHEMBL1131Retinoid receptor agonistAGONISTChEMBL
ALITRETINOINCHEMBL705Retinoid receptor agonistAGONISTChEMBL
BEXAROTENECHEMBL1023Retinoid X receptor agonistAGONISTChEMBL
DANTHRONCHEMBL53418Retinoid X receptor alpha antagonistANTAGONISTChEMBL
ETRETINATECHEMBL464Retinoid receptor agonistAGONISTChEMBL
IRX-4204CHEMBL75133Retinoid X receptor agonistAGONISTChEMBL
MOFAROTENECHEMBL146506Retinoid receptor modulatorMODULATORChEMBL
SDX-101CHEMBL1716091Retinoid X receptor alpha modulatorMODULATORChEMBL

Trials 81

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06739551ACITRETINPHASE2ClinicalTrials.gov
NCT06723171IRX-4204PHASE2ClinicalTrials.gov
NCT05401006ACITRETINPHASE4ClinicalTrials.gov
NCT05296304BEXAROTENEPHASE1ClinicalTrials.gov
NCT05259722ALITRETINOINPHASE32025-03-14ClinicalTrials.gov
NCT05203354ACITRETINPHASE4ClinicalTrials.gov
NCT05184348ACITRETINPHASE1ClinicalTrials.gov
NCT05106192BEXAROTENEClinicalTrials.gov
NCT04664829BEXAROTENEPHASE1ClinicalTrials.gov
NCT04537689ACITRETINPHASE4ClinicalTrials.gov

NIH grants 8435

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant662,025NIH's project files
P30CA008748Cancer Center Support Grant442,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)372,025NIH's project files
ZIABC005708Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers222,025NIH's project files
P30DK063491Diabetes Research Center (DRC)192,025NIH's project files
ZIABC005562Xenobiotic receptors192,025NIH's project files
P30CA016058Cancer Center Support Grant182,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)182,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant162,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)162,025NIH's project files

Papers 15812

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818011PubTator, text miningPubMed
42802156PubTator, text miningPubMed
42797461PubTator, text miningPubMed
42796232PubTator, text miningPubMed
42783391PubTator, text miningPubMed
42777982PubTator, text miningPubMed
42774750PubTator, text miningPubMed
42759629PubTator, text miningPubMed
42752562PubTator, text miningPubMed
42741844PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license