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RYR1: ryanodine receptor 1

1 protein, 26 patents, 2 drugs, 10 trials, 2,838 NIH grants and 5,457 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRYR1HGNC
Nameryanodine receptor 1HGNC
NCBI Gene ID6261NCBI Gene
HGNC IDHGNC:10483HGNC
EnsemblENSG00000196218NCBI Gene
AliasesCCO, CMYO1A, CMYO1B, CMYP1A, CMYP1B, KDS, MHS, MHS1, PPP1R137, RYDR, RYR, RYR-1, SKRRNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P21817Ryanodine receptor 15,0382Ensembl, GeneID, HGNCUniProt

Patents 26

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462510P21817Espacenet
EP 4641201 A22025-10-297726P21817Espacenet
JP 2025529142 A2025-09-043806P21817Espacenet
US 12371689 B22025-07-293806P21817Espacenet
JP 2025517969 A2025-06-127726P21817Espacenet
JP 2025032204 A2025-03-1135174P21817Espacenet
EP 4461818 A22024-11-1335174P21817Espacenet
JP 2024530931 A2024-08-2724P21817Espacenet
EP 4380580 A22024-06-1224P21817Espacenet
KR 1020240083171 A2024-06-1124P21817Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DANTROLENECHEMBL1201288Ryanodine receptor 1 antagonistANTAGONISTChEMBL
DANTROLENE SODIUMCHEMBL928Ryanodine receptor 1 antagonistANTAGONISTChEMBL

Trials 10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06966843DANTROLENEPHASE2/PHASE3ClinicalTrials.gov
NCT04134845DANTROLENEPHASE2/PHASE32025-08-15ClinicalTrials.gov
NCT03600376DANTROLENE SODIUMPHASE32021-04-26ClinicalTrials.gov
NCT03109288DANTROLENEPHASE1/PHASE2ClinicalTrials.gov
NCT02829268DANTROLENE SODIUMPHASE1/PHASE22024-03-13ClinicalTrials.gov
NCT02513095DANTROLENE SODIUMPHASE22017-05-09ClinicalTrials.gov
NCT01950520DANTROLENEPHASE22024-10-16ClinicalTrials.gov
NCT01024972DANTROLENEPHASE1/PHASE22015-03-05ClinicalTrials.gov
NCT00964548DANTROLENEPHASE1/PHASE22012-05-25ClinicalTrials.gov
NCT00796900DANTROLENEPHASE2/PHASE3ClinicalTrials.gov

NIH grants 2838

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01ES014901Molecular and Cellular Basis of PCB Developmental Neurotoxicity372,025NIH's project files
ZIANS003129Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies272,025NIH's project files
T32ES007059Advanced Training in Environmental Health Sciences202,025NIH's project files
R01HL092097Calmodulin and Regulation of Cardiac Ryanodine Receptor and CaMKII192,025NIH's project files
R01HL140934Exploring the Molecular Physiology of Atrial Fibrillation152,025NIH's project files
P30ES023513UC Davis Environmental Health Sciences Core Center112,025NIH's project files
P42ES013661Iowa Superfund Research Program: Airborne PCBs: Sources, Exposures, Toxicities, Remediation112,025NIH's project files
T32AR007592Interdisciplinary Training Program in Muscle Biology112,025NIH's project files
R25NS076445Summer Program for Undergraduate Rising Stars (SPURS), a Columbia University biomedical sciences pipeline program82,025NIH's project files
U01HG006379EHR-based Genomic Discovery and Implementation [Funded Extension]82,025NIH's project files

Papers 5457

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42813047PubTator, text miningPubMed
42810161PubTator, text miningPubMed
42807949PubTator, text miningPubMed
42794754PubTator, text miningPubMed
42792972PubTator, text miningPubMed
42786160PubTator, text miningPubMed
42756029PubTator, text miningPubMed
42741200PubTator, text miningPubMed
42737696PubTator, text miningPubMed
42700229PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license