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RYR2: ryanodine receptor 2

1 protein, 18 patents, 0 drugs, 0 trials, 3,972 NIH grants and 7,619 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRYR2HGNC
Nameryanodine receptor 2HGNC
NCBI Gene ID6262NCBI Gene
HGNC IDHGNC:10484HGNC
EnsemblENSG00000198626NCBI Gene
AliasesARVC2, ARVD2, RYR-2, RyR, VACRDS, VTSIPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q92736Ryanodine receptor 24,96726Ensembl, GeneID, HGNCUniProt

Patents 18

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462514Q92736Espacenet
EP 4641201 A22025-10-298212Q92736Espacenet
JP 2025529142 A2025-09-043807Q92736Espacenet
US 12371689 B22025-07-293807Q92736Espacenet
JP 2025517969 A2025-06-128212Q92736Espacenet
JP 2025032204 A2025-03-1135181Q92736Espacenet
EP 4461818 A22024-11-1335181Q92736Espacenet
JP 2023058610 A2023-04-2535181Q92736Espacenet
JP 2022141755 A2022-09-29138Q92736Espacenet
US 11446398 B22022-09-2076239Q92736Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3972

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL092097Calmodulin and Regulation of Cardiac Ryanodine Receptor and CaMKII332,025NIH's project files
R01ES014901Molecular and Cellular Basis of PCB Developmental Neurotoxicity252,025NIH's project files
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation242,025NIH's project files
R01HL140934Exploring the Molecular Physiology of Atrial Fibrillation192,025NIH's project files
R01HL136389The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis182,025NIH's project files
P42ES013661Iowa Superfund Research Program: Airborne PCBs: Sources, Exposures, Toxicities, Remediation172,025NIH's project files
P30ES005605Environmental Health Sciences Research Center162,025NIH's project files
R35HL144980Toward a Mechanism-Based Approach to Treating Cardiac Arrhythmia162,025NIH's project files
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology142,025NIH's project files
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling122,025NIH's project files

Papers 7619

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820874PubTator, text miningPubMed
42817169PubTator, text miningPubMed
42794576PubTator, text miningPubMed
42785170PubTator, text miningPubMed
42769728PubTator, text miningPubMed
42761222PubTator, text miningPubMed
42753271PubTator, text miningPubMed
42721222PubTator, text miningPubMed
42717762PubTator, text miningPubMed
42697419PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license