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Gene · 6272

SORT1: sortilin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SORT1: sortilin 1. Genes, record 6272. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6272

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Gene

Symbol
SORT1
HGNC
Name
sortilin 1
HGNC
NCBI Gene ID
6272
NCBI Gene
HGNC ID
HGNC:11186
HGNC
Ensembl
ENSG00000134243
NCBI Gene
Aliases
Gp95, LDLCQ6, NT3, NTR3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99523Sortilin83117Ensembl, GeneID, HGNC

Source UniProt

Patents118

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026210020 A12026-10-081Q99523Espacenet
EP 4650780 A22025-11-191594Q99523Espacenet
JP 2025169942 A2025-11-141297Q99523Espacenet
EP 4640849 A22025-10-29187Q99523Espacenet
EP 4641201 A22025-10-291203Q99523Espacenet
EP 4641202 A22025-10-2960Q99523Espacenet
EP 4641203 A22025-10-2944Q99523Espacenet
EP 4630558 A22025-10-1514Q99523Espacenet
EP 4619041 A12025-09-2449Q99523Espacenet
JP 2025529142 A2025-09-044401Q99523Espacenet

1 to 10 of 118

See all 118 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,739

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSORT1 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)192025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal122025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)112025
U01HG006379EHR-based Genomic Discovery and Implementation [Funded Extension]102025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions82025
P30DK020572Michigan Diabetes Research Center (MDRC)82025
ZIAHL006001Framingham Project/Levy82025
ZIAHL006170Cardiovascular Genomics and Bioinformatics projects82025
R01NS088448Function of TMEM106B in Neurodegeneration72025
UL1TR001863Yale Clinical and Translational Science Award72025

1 to 10 of 2,739Source NIH's project files

See all 2,739 nih grants

Papers2,809

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multiplatform single-cell and spatial transcriptomics reveal sex-specific malignant states and architecture in male breast cancer.Sci Adv202642789703PubTator, text miningPubMed
Tumor-homing peptides in precision oncology.J Control Release202642749136PubTator, text miningPubMed
Sortilin Immunoreactivity Is Associated with Lymphatic and Extrathyroidal Invasion in Medullary Thyroid Carcinoma: A Preliminary Single-Center Study.Endocr Res202642747799PubTator, text miningPubMed
Integrative analysis of single-cell multi-omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's disease.Clin Transl Med202642728785PubTator, text miningPubMed
Assessing genetic risk factors for early-onset coronary artery disease in Iranians.Res Pract Thromb Haemost202642699092PubTator, text miningPubMed
The highest clinical trial failure rate for any disease in modern medicine: How both amyloid- and non-amyloid-targeting therapies failed to alter disease course in Alzheimer's disease.Free Neuropathol202642683436PubTator, text miningPubMed
Integrative single-nucleus transcriptomic analysis identifies UBE2C+ proliferative tumor cells and immune-stromal regulatory crosstalk in small cell lung cancer.Front Immunol202642614523PubTator, text miningPubMed
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia.Oral Dis202642576356PubTator, text miningPubMed
Toxicological impact of benzo[a]pyrene on esophageal cancer: an integrated analysis via network toxicology, machine learning, and molecular docking.Front Immunol202642528957PubTator, text miningPubMed

1 to 10 of 2,809

See all 2,809 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6272

GET https://conductscience.org/api/genes/v1/6272/patents?page=2