ConductScience.org, home

Library / Genes

CFB: complement factor B

1 protein, 185 patents, 2 drugs, 29 trials, 2,572 NIH grants and 5,137 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCFBHGNC
Namecomplement factor BHGNC
NCBI Gene ID629NCBI Gene
HGNC IDHGNC:1037HGNC
EnsemblENSG00000243649NCBI Gene
AliasesAHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00751Complement factor B76428Ensembl, GeneID, HGNCUniProt

Patents 185

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026222481 A12026-10-221P00751Espacenet
JP 2026515744 A2026-05-19122P00751Espacenet
JP 2026069789 A2026-04-2449P00751Espacenet
JP 2026510831 A2026-04-1066P00751Espacenet
JP 2026004568 A2026-01-1442107P00751Espacenet
JP 2026004568 A2026-01-1442108P00751Espacenet
JP 2026004568 A2026-01-1442110P00751Espacenet
JP 2026004568 A2026-01-1442111P00751Espacenet
JP 2026004568 A2026-01-1442112P00751Espacenet
JP 2026004568 A2026-01-1442113P00751Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IPTACOPANCHEMBL4594448Complement factor B inhibitorINHIBITORChEMBL
IPTACOPAN HYDROCHLORIDECHEMBL5095401Complement factor B inhibitorINHIBITORChEMBL

Trials 29

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07347990IPTACOPANClinicalTrials.gov
NCT06994845IPTACOPANPHASE3ClinicalTrials.gov
NCT06934967IPTACOPANPHASE3ClinicalTrials.gov
NCT06931691IPTACOPANClinicalTrials.gov
NCT06903234IPTACOPANClinicalTrials.gov
NCT06847607IPTACOPANClinicalTrials.gov
NCT06797518IPTACOPANPHASE2ClinicalTrials.gov
NCT06517758IPTACOPANPHASE3ClinicalTrials.gov
NCT06388941IPTACOPANPHASE2ClinicalTrials.gov
NCT05935215IPTACOPANPHASE3ClinicalTrials.gov

NIH grants 2572

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies202,025NIH's project files
R01DK110023C3 Glomerulopathy -- A Collaborative Study122,025NIH's project files
P30EY014800University of Utah Core Vision Research Grant102,025NIH's project files
ZIAEY000489Age-Related Eye Disease Follow-up Study (AREDS) Follow-up Study102,025NIH's project files
K12EY016335Harvard-Vision Clinical Scientist Development Program82,025NIH's project files
P30CA008748Cancer Center Support Grant82,025NIH's project files
P30EY001583P30 Core Grant For Vision Research82,025NIH's project files
R01AR051749Complement in the Pathogenesis of Autoimmune Arthritis82,025NIH's project files
I01RX000444Complement Factor H-based Therapeutic Strategies in Macular Degeneration72,025NIH's project files
R01EY022445Use of Correlated Data Methods in Ophthalmology72,025NIH's project files

Papers 5137

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42781234PubTator, text miningPubMed
42780117PubTator, text miningPubMed
42769061PubTator, text miningPubMed
42762750PubTator, text miningPubMed
42755451PubTator, text miningPubMed
42746023PubTator, text miningPubMed
42718940PubTator, text miningPubMed
42713733PubTator, text miningPubMed
42697461PubTator, text miningPubMed
42575336PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license