Gene · 6300
MAPK12: mitogen-activated protein kinase 12
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MAPK12: mitogen-activated protein kinase 12. Genes, record 6300. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6300
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P53778 | Mitogen-activated protein kinase 12 | 367 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents68
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12539325 B2 | 2026-02-03 | 50 | P53778 | Espacenet |
| JP 2026000906 A | 2026-01-06 | 234 | P53778 | Espacenet |
| US 12252709 B2 | 2025-03-18 | 26 | P53778 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 31190 | P53778 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 31190 | P53778 | Espacenet |
| US 12133879 B2 | 2024-11-05 | 50 | P53778 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7034 | P53778 | Espacenet |
| US 11920164 B2 | 2024-03-05 | 44 | P53778 | Espacenet |
| US 11872193 B2 | 2024-01-16 | 50 | P53778 | Espacenet |
| US 11726090 B2 | 2023-08-15 | 17 | P53778 | Espacenet |
1 to 10 of 68
See all 68 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,295
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MAPK12 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 4 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
| R01AA015407 | Endoplasmic Reticulum Stress and Alcohol Neurotoxicity | 4 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 3 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 3 | 2025 |
| R01HL016037 | Molecular Regulation of Cardiovascular 7 TM Receptors | 3 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,295Source NIH's project files
See all 1,295 nih grantsPapers1,954
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Triple-Frequency Electromagnetic Stimulation Combined with Fingolimod Reduces Breast Cancer Cell Proliferation and Metastasis-Associated Extracellular Vesicle Protein Levels. | Pharmaceuticals (Basel) | 2026 | 42797444 | PubTator, text mining | PubMed |
| USP32-mediated stabilization of MAPK12 promotes lung adenocarcinoma progression by inhibiting autophagy-ferroptosis. | Commun Biol | 2026 | 42477452 | PubTator, text mining | PubMed |
| Discrete On-DNA Screening: A Frontier for Rapid Hit-to-Lead Optimization Applied to p38α. | ACS Med Chem Lett | 2026 | 42445005 | PubTator, text mining | PubMed |
| Single-cell RNA sequencing and cross-species analysis revealed the role of T cell-driven inflammatory responses in the pathogenesis of aortic dissection. | BMC Cardiovasc Disord | 2026 | 42436415 | PubTator, text mining | PubMed |
| P38γ drives aerobic glycolysis in liver sinusoidal endothelial cells and regulates alcoholic liver disease via the PFKFB3 signaling pathway. | Mol Biol Rep | 2026 | 42201586 | PubTator, text mining | PubMed |
| An exploration of GuaLouQuMaiWan related novel prognostic model and search for potential compound pachymic acid in bladder cancer. | Front Oncol | 2026 | 42063714 | PubTator, text mining | PubMed |
| Gut microbiome in type 2 diabetes: insights from metagenomics, multi-omics, and diet-microbe interactions. | Gut Microbes | 2026 | 41845564 | PubTator, text mining | PubMed |
| Targeting p38α, p38γ, and ERα with bioactive compounds from royal jelly for anti-breast cancer activity: A comprehensive in-silico study using fingerprint analysis, molecular dynamics, MEP, and PCA. | Biochem Biophys Res Commun | 2026 | 41819753 | PubTator, text mining | PubMed |
| GNAQ positive hepatic vascular tumors in a patient with neurofibromatosis type 1: A case report. | JAAD Case Rep | 2026 | 41808682 | PubTator, text mining | PubMed |
| USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination. | Int J Biol Sci | 2026 | 41800264 | PubTator, text mining | PubMed |
1 to 10 of 1,954
See all 1,954 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6300
GET https://conductscience.org/api/genes/v1/6300/patents?page=2