ConductScience.org, home

Gene · 6300

MAPK12: mitogen-activated protein kinase 12

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. MAPK12: mitogen-activated protein kinase 12. Genes, record 6300. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6300

On this page

Gene

Symbol
MAPK12
HGNC
Name
mitogen-activated protein kinase 12
HGNC
NCBI Gene ID
6300
NCBI Gene
HGNC ID
HGNC:6874
HGNC
Ensembl
ENSG00000188130
NCBI Gene
Aliases
ERK-6, ERK3, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3, p38gamma
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P53778Mitogen-activated protein kinase 123674Ensembl, GeneID, HGNC

Source UniProt

Patents68

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0350P53778Espacenet
JP 2026000906 A2026-01-06234P53778Espacenet
US 12252709 B22025-03-1826P53778Espacenet
JP 2025032204 A2025-03-1131190P53778Espacenet
EP 4461818 A22024-11-1331190P53778Espacenet
US 12133879 B22024-11-0550P53778Espacenet
JP 2024123008 A2024-09-107034P53778Espacenet
US 11920164 B22024-03-0544P53778Espacenet
US 11872193 B22024-01-1650P53778Espacenet
US 11726090 B22023-08-1517P53778Espacenet

1 to 10 of 68

See all 68 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,295

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAPK12 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA033572Cancer Center Support Grant42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
R01AA015407Endoplasmic Reticulum Stress and Alcohol Neurotoxicity42025
P30CA046934University of Colorado Cancer Center Support Grant32025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant32025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA008748Cancer Center Support Grant22025
P30CA013148Comprehensive Cancer Center Support Grant22025

1 to 10 of 1,295Source NIH's project files

See all 1,295 nih grants

Papers1,954

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Triple-Frequency Electromagnetic Stimulation Combined with Fingolimod Reduces Breast Cancer Cell Proliferation and Metastasis-Associated Extracellular Vesicle Protein Levels.Pharmaceuticals (Basel)202642797444PubTator, text miningPubMed
USP32-mediated stabilization of MAPK12 promotes lung adenocarcinoma progression by inhibiting autophagy-ferroptosis.Commun Biol202642477452PubTator, text miningPubMed
Discrete On-DNA Screening: A Frontier for Rapid Hit-to-Lead Optimization Applied to p38α.ACS Med Chem Lett202642445005PubTator, text miningPubMed
Single-cell RNA sequencing and cross-species analysis revealed the role of T cell-driven inflammatory responses in the pathogenesis of aortic dissection.BMC Cardiovasc Disord202642436415PubTator, text miningPubMed
P38γ drives aerobic glycolysis in liver sinusoidal endothelial cells and regulates alcoholic liver disease via the PFKFB3 signaling pathway.Mol Biol Rep202642201586PubTator, text miningPubMed
An exploration of GuaLouQuMaiWan related novel prognostic model and search for potential compound pachymic acid in bladder cancer.Front Oncol202642063714PubTator, text miningPubMed
Gut microbiome in type 2 diabetes: insights from metagenomics, multi-omics, and diet-microbe interactions.Gut Microbes202641845564PubTator, text miningPubMed
Targeting p38α, p38γ, and ERα with bioactive compounds from royal jelly for anti-breast cancer activity: A comprehensive in-silico study using fingerprint analysis, molecular dynamics, MEP, and PCA.Biochem Biophys Res Commun202641819753PubTator, text miningPubMed
GNAQ positive hepatic vascular tumors in a patient with neurofibromatosis type 1: A case report.JAAD Case Rep202641808682PubTator, text miningPubMed
USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination.Int J Biol Sci202641800264PubTator, text miningPubMed

1 to 10 of 1,954

See all 1,954 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6300

GET https://conductscience.org/api/genes/v1/6300/patents?page=2