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Gene · 6303

SAT1: spermidine/spermine N1-acetyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SAT1: spermidine/spermine N1-acetyltransferase 1. Genes, record 6303. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6303

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Gene

Symbol
SAT1
HGNC
Name
spermidine/spermine N1-acetyltransferase 1
HGNC
NCBI Gene ID
6303
NCBI Gene
HGNC ID
HGNC:10540
HGNC
Ensembl
ENSG00000130066
NCBI Gene
Aliases
DC21, KFSD, KFSDX, SAT, SLEB19, SSAT, SSAT-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P21673Diamine acetyltransferase 117110Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465257P21673Espacenet
EP 4650780 A22025-11-1910138P21673Espacenet
EP 4641202 A22025-10-295729P21673Espacenet
JP 2025517970 A2025-06-1210138P21673Espacenet
JP 2025032204 A2025-03-1135231P21673Espacenet
KR 1020250017231 A2025-02-045729P21673Espacenet
EP 4461818 A22024-11-1335231P21673Espacenet
JP 2024516160 A2024-04-126P21673Espacenet
KR 1020240001182 A2024-01-036P21673Espacenet
JP 2023058610 A2023-04-2535231P21673Espacenet

1 to 10 of 52

See all 52 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,364

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSAT1 papersNewest fiscal year
P30CA016056Roswell Park Cancer Center Support Grant172025
P30CA016672Cancer Center Support Grant132025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant102025
P30CA006973Regional Oncology Research Center92025
P30DK058404Molecular and Cellular Basis for Digestive Diseases62025
P50HD052120Learning Disabilities Translational Science Collective: Building on the Florida LDRC62025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer52025
P30CA062203Cancer Center Support Grant52025
P30CA008748Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025

1 to 10 of 1,364Source NIH's project files

See all 1,364 nih grants

Papers2,973

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated Single-Cell and Machine-Learning Analysis Identifies Antigen-Presenting Macrophage-Associated Genes in Pediatric Community-Acquired Pneumonia.Curr Med Chem202642816984PubTator, text miningPubMed
Integrative machine learning and transcriptomic analysis reveal a ferroptosis gene signature for pediatric Mycoplasma pneumoniae pneumonia.Front Cell Dev Biol202642812455PubTator, text miningPubMed
A biomarker-driven approach to targeting polyamine depletion in triple negative breast cancer.Biomark Res202642811374PubTator, text miningPubMed
High-Density Type I Collagen Promotes IFN-γ+ CD8+ T Cell Exhaustion via SAT1-ASS1-Mediated Glutamine Accumulation and Ferroptosis in Triple-Negative Breast Cancer.Adv Sci (Weinh)202642801687PubTator, text miningPubMed
Evolutionary and Spatiotemporal Dynamics of Foot-and-Mouth Disease Virus in Ethiopia (1957-2025): A Molecular Perspective on Serotype Persistence and Emergence.Transbound Emerg Dis202642799644PubTator, text miningPubMed
Unravelling Ferroptosis in Sepsis: A Comprehensive Integrative Transcriptomic Analysis Across Age and Disease Severity.Bioinform Biol Insights202642756334PubTator, text miningPubMed
SAT1 promotes prostate cancer progression and decreases enzalutamide sensitivity by enhancing spermine catabolism.Hum Cell202642744967PubTator, text miningPubMed
Polyethylene terephthalate micro-/nanoplastics suppress SAT1-dependent ferroptosis in triple-negative breast cancer.Environ Int202642731238PubTator, text miningPubMed
Divergent transcriptional programs and constrained metabolic states reveal selective metabolic dependencies in chemoresistant luminal breast cancer.Cancer Drug Resist202642729982PubTator, text miningPubMed
Polyamine Metabolism in Brain Health and Disease.Neuropharmacol Ther202642631064PubTator, text miningPubMed

1 to 10 of 2,973

See all 2,973 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6303

GET https://conductscience.org/api/genes/v1/6303/patents?page=2