ConductScience.org, home

Library / Genes

SCN1A: sodium voltage-gated channel alpha subunit 1

1 protein, 92 patents, 83 drugs, 1,301 trials, 2,165 NIH grants and 4,695 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSCN1AHGNC
Namesodium voltage-gated channel alpha subunit 1HGNC
NCBI Gene ID6323NCBI Gene
HGNC IDHGNC:10585HGNC
EnsemblENSG00000144285NCBI Gene
AliasesDEE6, DEE6A, DEE6B, DRVT, EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEINCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P35498Sodium channel protein type 1 subunit alpha2,0091Ensembl, GeneID, HGNCUniProt

Patents 92

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4791883 A12026-08-19155P35498Espacenet
EP 4791886 A12026-08-19155P35498Espacenet
JP 2026094314 A2026-06-09104P35498Espacenet
JP 2026021360 A2026-02-10132P35498Espacenet
JP 2026004568 A2026-01-1463883P35498Espacenet
JP 2026004568 A2026-01-1463886P35498Espacenet
EP 4641201 A22025-10-293778P35498Espacenet
JP 2025148444 A2025-10-07863P35498Espacenet
JP 2025529142 A2025-09-043840P35498Espacenet
JP 2025118768 A2025-08-131P35498Espacenet

Drugs 83

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINECHEMBL370805Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINE HYDROCHLORIDECHEMBL529437Sodium channel alpha subunit blockerBLOCKERChEMBL

Trials 1301

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07599800LIDOCAINEPHASE2/PHASE3ClinicalTrials.gov
NCT07592143LIDOCAINEPHASE3ClinicalTrials.gov
NCT07588750TOPIRAMATEClinicalTrials.gov
NCT07572994LIDOCAINEClinicalTrials.gov
NCT07568496LIDOCAINEClinicalTrials.gov
NCT07547371ARTICAINE HYDROCHLORIDEClinicalTrials.gov
NCT07546370PRILOCAINEPHASE4ClinicalTrials.gov
NCT07546370LIDOCAINEPHASE4ClinicalTrials.gov
NCT07536594LIDOCAINEClinicalTrials.gov
NCT07511400LIDOCAINEEARLY_PHASE1ClinicalTrials.gov

NIH grants 2165

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01NS034509Functional Genetics of the Neuronal Sodium Channel Gene SCN8A372,025NIH's project files
U24NS120854ClinGen Expert Curation Panel for the Epilepsies132,025NIH's project files
UL1TR001878Institutional Clinical and Translational Science Award112,025NIH's project files
T32MH065215Postdoctoral Program in Functional Neurogenomics102,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award82,025NIH's project files
R01NS029709Excitability and Plasticity of Developing Epileptic Brain62,025NIH's project files
R01NS032457Cell Identity Determination in Human Brain: Somatic Mutation and Cell Lineage62,025NIH's project files
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center52,025NIH's project files
R01MH101221Rare Mutations and Autism Spectrum Disorders52,025NIH's project files
R01NS110869Interneuron axonopathy underlies circuit dysfunction in a mouse model of Dravet syndrome52,025NIH's project files

Papers 4695

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42751003PubTator, text miningPubMed
42749564PubTator, text miningPubMed
42742013PubTator, text miningPubMed
42731411PubTator, text miningPubMed
42720997PubTator, text miningPubMed
42711132PubTator, text miningPubMed
42707628PubTator, text miningPubMed
42700752PubTator, text miningPubMed
42679814PubTator, text miningPubMed
42667410PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license