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Gene · 6329

SCN4A: sodium voltage-gated channel alpha subunit 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCN4A: sodium voltage-gated channel alpha subunit 4. Genes, record 6329. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6329

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Gene

Symbol
SCN4A
HGNC
Name
sodium voltage-gated channel alpha subunit 4
HGNC
NCBI Gene ID
6329
NCBI Gene
HGNC ID
HGNC:10591
HGNC
Ensembl
ENSG00000007314
NCBI Gene
Aliases
CMS16, CMYO22A, CMYP22A, HOKPP2, HYKPP, HYPP, NAC1A, Na(V)1.4, Nav1.4, SkM1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35499Sodium channel protein type 4 subunit alpha1,8363Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463905P35499Espacenet
EP 4641201 A22025-10-2914213P35499Espacenet
JP 2025529142 A2025-09-043846P35499Espacenet
US 12371689 B22025-07-293846P35499Espacenet
JP 2025517969 A2025-06-1214213P35499Espacenet
US 11464217 B22022-10-1124P35499Espacenet
US 11446398 B22022-09-2080230P35499Espacenet
US 11400116 B22022-08-0295P35499Espacenet
JP 2022524081 A2022-04-27183201P35499Espacenet
JP 2022520819 A2022-04-0126P35499Espacenet

1 to 10 of 22

See all 22 patents

Drugs88

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
BUPIVACAINECHEMBL1098Sodium channel protein type IV alpha subunit blockerBLOCKERChEMBL
BUPIVACAINE HYDROCHLORIDECHEMBL1200396Sodium channel protein type IV alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL

1 to 10 of 88

See all 88 drugs

Trials1,648

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 1,648

See all 1,648 trials

NIH grants840

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCN4A papersNewest fiscal year
R01AR063182Disease Pathogenesis and Modification for CaV1.1-Associated Hypokalemic Periodic Paralysis102025
R01GM030376The Electrophysiological Studies of Voltage Gated Channels62025
R01HL112808Structural Basis for Antiarrhythmic Drug Action62025
P20GM103408Idaho INBRE Program42025
R01DC007664Structural Studies of Ion Channel Assembly and Signaling Complexes42025
R01GM042699Biochemistry of Pre-mRNA Splicing42025
P30CA016520Abramson Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
R01AR074985Novel Approaches to Therapy of Muscle Ion Channelopathies32025
R01NS034509Functional Genetics of the Neuronal Sodium Channel Gene SCN8A32025

1 to 10 of 840Source NIH's project files

See all 840 nih grants

Papers1,928

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SCN4A Channelopathies: From Disease Mechanisms to Variant Interpretation.Genes (Basel)202642793010PubTator, text miningPubMed
A structure-based model that describes activation and inactivation of a sodium channel.J Physiol202642786725PubTator, text miningPubMed
A New Disease Gene for Hypokalemic Periodic Paralysis, KCNA7 , Established in a Multigenerational Family.bioRxiv202642780157PubTator, text miningPubMed
Recurrent Severe Viral-Induced Rhabdomyolysis Associated With Underlying Genetic Variants in a Young Adult: A Case Report.Cureus202642755847PubTator, text miningPubMed
Inclusion-Body Myopathy with Paget Disease of the Bone and Frontotemporal Dementia (IBMPFD) with SCN4A Mutation: Modifying Factor or Not?Diagnostics (Basel)202642739263PubTator, text miningPubMed
Adult-Onset Hypokalemic Periodic Paralysis With the p.Arg672Cys Variant in the SCN4A Gene: A Case Report.Cureus202642666319PubTator, text miningPubMed
Palpebral myotonia mimicking intermittent strabismus in a child with SCN4A-related sodium channel myotonia.Strabismus202642663436PubTator, text miningPubMed
Batrachotoxin-sensitive sodium channels in toxic birds challenge "target mutation" strategy of toxin autoresistance.iScience202642592513PubTator, text miningPubMed
Systematic reanalysis of next-generation sequencing data in 101 neuromuscular disorder families enhances diagnostic yield, reveals intronic variants, and identifies a novel disease gene.J Neurol202642474733PubTator, text miningPubMed
Myotonia Mimicking Paroxysmal Dystonia: Two Cases of SCN4A Temperature-Sensitive Sodium Channelopathy.Mov Disord Clin Pract202642433115PubTator, text miningPubMed

1 to 10 of 1,928

See all 1,928 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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