Gene · 6329
SCN4A: sodium voltage-gated channel alpha subunit 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SCN4A: sodium voltage-gated channel alpha subunit 4. Genes, record 6329. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6329
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P35499 | Sodium channel protein type 4 subunit alpha | 1,836 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63905 | P35499 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 14213 | P35499 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3846 | P35499 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3846 | P35499 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 14213 | P35499 | Espacenet |
| US 11464217 B2 | 2022-10-11 | 24 | P35499 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80230 | P35499 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 95 | P35499 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 183201 | P35499 | Espacenet |
| JP 2022520819 A | 2022-04-01 | 26 | P35499 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs88
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ARTICAINE | CHEMBL1093 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| ARTICAINE HYDROCHLORIDE | CHEMBL1200819 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE | CHEMBL1200 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE HYDROCHLORIDE | CHEMBL1200654 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BUPIVACAINE | CHEMBL1098 | Sodium channel protein type IV alpha subunit blocker | BLOCKER | ChEMBL |
| BUPIVACAINE HYDROCHLORIDE | CHEMBL1200396 | Sodium channel protein type IV alpha subunit blocker | BLOCKER | ChEMBL |
| CARBAMAZEPINE | CHEMBL108 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | Sodium channel alpha subunit inhibitor | INHIBITOR | ChEMBL |
| CHLOROPROCAINE | CHEMBL1179047 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CHLOROPROCAINE HYDROCHLORIDE | CHEMBL944 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
1 to 10 of 88
See all 88 drugsTrials1,648
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07599800 | LIDOCAINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07592143 | BUPIVACAINE | PHASE3 | ClinicalTrials.gov | |
| NCT07592143 | LIDOCAINE | PHASE3 | ClinicalTrials.gov | |
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07573969 | BUPIVACAINE | PHASE3 | ClinicalTrials.gov | |
| NCT07572994 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07568496 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07547371 | ARTICAINE HYDROCHLORIDE | ClinicalTrials.gov | ||
| NCT07546370 | PRILOCAINE | PHASE4 | ClinicalTrials.gov | |
| NCT07546370 | LIDOCAINE | PHASE4 | ClinicalTrials.gov |
1 to 10 of 1,648
See all 1,648 trialsNIH grants840
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SCN4A papers | Newest fiscal year |
|---|---|---|---|
| R01AR063182 | Disease Pathogenesis and Modification for CaV1.1-Associated Hypokalemic Periodic Paralysis | 10 | 2025 |
| R01GM030376 | The Electrophysiological Studies of Voltage Gated Channels | 6 | 2025 |
| R01HL112808 | Structural Basis for Antiarrhythmic Drug Action | 6 | 2025 |
| P20GM103408 | Idaho INBRE Program | 4 | 2025 |
| R01DC007664 | Structural Studies of Ion Channel Assembly and Signaling Complexes | 4 | 2025 |
| R01GM042699 | Biochemistry of Pre-mRNA Splicing | 4 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| R01AR074985 | Novel Approaches to Therapy of Muscle Ion Channelopathies | 3 | 2025 |
| R01NS034509 | Functional Genetics of the Neuronal Sodium Channel Gene SCN8A | 3 | 2025 |
1 to 10 of 840Source NIH's project files
See all 840 nih grantsPapers1,928
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| SCN4A Channelopathies: From Disease Mechanisms to Variant Interpretation. | Genes (Basel) | 2026 | 42793010 | PubTator, text mining | PubMed |
| A structure-based model that describes activation and inactivation of a sodium channel. | J Physiol | 2026 | 42786725 | PubTator, text mining | PubMed |
| A New Disease Gene for Hypokalemic Periodic Paralysis, KCNA7 , Established in a Multigenerational Family. | bioRxiv | 2026 | 42780157 | PubTator, text mining | PubMed |
| Recurrent Severe Viral-Induced Rhabdomyolysis Associated With Underlying Genetic Variants in a Young Adult: A Case Report. | Cureus | 2026 | 42755847 | PubTator, text mining | PubMed |
| Inclusion-Body Myopathy with Paget Disease of the Bone and Frontotemporal Dementia (IBMPFD) with SCN4A Mutation: Modifying Factor or Not? | Diagnostics (Basel) | 2026 | 42739263 | PubTator, text mining | PubMed |
| Adult-Onset Hypokalemic Periodic Paralysis With the p.Arg672Cys Variant in the SCN4A Gene: A Case Report. | Cureus | 2026 | 42666319 | PubTator, text mining | PubMed |
| Palpebral myotonia mimicking intermittent strabismus in a child with SCN4A-related sodium channel myotonia. | Strabismus | 2026 | 42663436 | PubTator, text mining | PubMed |
| Batrachotoxin-sensitive sodium channels in toxic birds challenge "target mutation" strategy of toxin autoresistance. | iScience | 2026 | 42592513 | PubTator, text mining | PubMed |
| Systematic reanalysis of next-generation sequencing data in 101 neuromuscular disorder families enhances diagnostic yield, reveals intronic variants, and identifies a novel disease gene. | J Neurol | 2026 | 42474733 | PubTator, text mining | PubMed |
| Myotonia Mimicking Paroxysmal Dystonia: Two Cases of SCN4A Temperature-Sensitive Sodium Channelopathy. | Mov Disord Clin Pract | 2026 | 42433115 | PubTator, text mining | PubMed |
1 to 10 of 1,928
See all 1,928 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6329
GET https://conductscience.org/api/genes/v1/6329/patents?page=2