SCN5A: sodium voltage-gated channel alpha subunit 5
1 protein, 66 patents, 93 drugs, 1,385 trials, 3,568 NIH grants and 8,126 papers.
Gene 7
Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.
Proteins 1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in | Source |
|---|---|---|---|---|---|
| Q14524 | Sodium channel protein type 5 subunit alpha | 2,016 | 16 | Ensembl, GeneID, HGNC | UniProt |
Patents 66
Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63914 | Q14524 | Espacenet |
| WO 2025229182 A1 | 2025-11-06 | 1 | Q14524 | Espacenet |
| EP 4644902 A1 | 2025-11-05 | 1 | Q14524 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5475 | Q14524 | Espacenet |
| EP 4614149 A1 | 2025-09-10 | 1 | Q14524 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3848 | Q14524 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3848 | Q14524 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5475 | Q14524 | Espacenet |
| WO 2025021888 A1 | 2025-01-30 | 1 | Q14524 | Espacenet |
| EP 4498088 A1 | 2025-01-29 | 1 | Q14524 | Espacenet |
Drugs 93
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ARTICAINE | CHEMBL1093 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| ARTICAINE HYDROCHLORIDE | CHEMBL1200819 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| AZD1305 | CHEMBL3545169 | Sodium channel protein type V alpha subunit blocker | BLOCKER | ChEMBL |
| AZD7009 | CHEMBL3545040 | Sodium channel protein type V alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE | CHEMBL1200 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE HYDROCHLORIDE | CHEMBL1200654 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CARBAMAZEPINE | CHEMBL108 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | Sodium channel alpha subunit inhibitor | INHIBITOR | ChEMBL |
| CHLOROPROCAINE | CHEMBL1179047 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CHLOROPROCAINE HYDROCHLORIDE | CHEMBL944 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
Trials 1385
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07599800 | LIDOCAINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07592143 | LIDOCAINE | PHASE3 | ClinicalTrials.gov | |
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07572994 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07568496 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07547371 | ARTICAINE HYDROCHLORIDE | ClinicalTrials.gov | ||
| NCT07546370 | PRILOCAINE | PHASE4 | ClinicalTrials.gov | |
| NCT07546370 | LIDOCAINE | PHASE4 | ClinicalTrials.gov | |
| NCT07536594 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07511400 | LIDOCAINE | EARLY_PHASE1 | ClinicalTrials.gov |
NIH grants 3568
NIH projects whose papers are about the gene, through NIH's grant-paper links.
| Project | Title | Its papers about the gene | Newest fiscal year | Source |
|---|---|---|---|---|
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 33 | 2,025 | NIH's project files |
| R01DK052766 | Mechanotransduction in Intestinal Smooth Muscle Cells | 28 | 2,025 | NIH's project files |
| P30DK063491 | Diabetes Research Center (DRC) | 21 | 2,025 | NIH's project files |
| R01DK057061 | Calcium Dynamics in Interstitial Cells of Cajal | 15 | 2,025 | NIH's project files |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 15 | 2,025 | NIH's project files |
| P30CA068485 | Cancer Center Support Grant | 12 | 2,025 | NIH's project files |
| U01HG006379 | EHR-based Genomic Discovery and Implementation [Funded Extension] | 12 | 2,025 | NIH's project files |
| R01HL135109 | Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation | 11 | 2,025 | NIH's project files |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 10 | 2,025 | NIH's project files |
| R01HL113006 | Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling | 10 | 2,025 | NIH's project files |
Papers 8126
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| PMID | Found by | Source |
|---|---|---|
| 42815839 | PubTator, text mining | PubMed |
| 42813533 | PubTator, text mining | PubMed |
| 42798645 | PubTator, text mining | PubMed |
| 42787793 | PubTator, text mining | PubMed |
| 42781677 | PubTator, text mining | PubMed |
| 42780784 | PubTator, text mining | PubMed |
| 42764720 | PubTator, text mining | PubMed |
| 42758283 | PubTator, text mining | PubMed |
| 42753271 | PubTator, text mining | PubMed |
| 42750665 | PubTator, text mining | PubMed |
Release gene-search-2026-11-11-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
HGNC: CC0: https://www.genenames.org/about/license/
NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH's project files and grant-paper links: Public domain (NIH RePORTER)
Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubTator 3: Public domain
UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license