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SCN5A: sodium voltage-gated channel alpha subunit 5

1 protein, 66 patents, 93 drugs, 1,385 trials, 3,568 NIH grants and 8,126 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSCN5AHGNC
Namesodium voltage-gated channel alpha subunit 5HGNC
NCBI Gene ID6331NCBI Gene
HGNC IDHGNC:10593HGNC
EnsemblENSG00000183873NCBI Gene
AliasesCDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q14524Sodium channel protein type 5 subunit alpha2,01616Ensembl, GeneID, HGNCUniProt

Patents 66

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463914Q14524Espacenet
WO 2025229182 A12025-11-061Q14524Espacenet
EP 4644902 A12025-11-051Q14524Espacenet
EP 4641201 A22025-10-295475Q14524Espacenet
EP 4614149 A12025-09-101Q14524Espacenet
JP 2025529142 A2025-09-043848Q14524Espacenet
US 12371689 B22025-07-293848Q14524Espacenet
JP 2025517969 A2025-06-125475Q14524Espacenet
WO 2025021888 A12025-01-301Q14524Espacenet
EP 4498088 A12025-01-291Q14524Espacenet

Drugs 93

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
AZD1305CHEMBL3545169Sodium channel protein type V alpha subunit blockerBLOCKERChEMBL
AZD7009CHEMBL3545040Sodium channel protein type V alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL

Trials 1385

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07599800LIDOCAINEPHASE2/PHASE3ClinicalTrials.gov
NCT07592143LIDOCAINEPHASE3ClinicalTrials.gov
NCT07588750TOPIRAMATEClinicalTrials.gov
NCT07572994LIDOCAINEClinicalTrials.gov
NCT07568496LIDOCAINEClinicalTrials.gov
NCT07547371ARTICAINE HYDROCHLORIDEClinicalTrials.gov
NCT07546370PRILOCAINEPHASE4ClinicalTrials.gov
NCT07546370LIDOCAINEPHASE4ClinicalTrials.gov
NCT07536594LIDOCAINEClinicalTrials.gov
NCT07511400LIDOCAINEEARLY_PHASE1ClinicalTrials.gov

NIH grants 3568

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL332,025NIH's project files
R01DK052766Mechanotransduction in Intestinal Smooth Muscle Cells282,025NIH's project files
P30DK063491Diabetes Research Center (DRC)212,025NIH's project files
R01DK057061Calcium Dynamics in Interstitial Cells of Cajal152,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal152,025NIH's project files
P30CA068485Cancer Center Support Grant122,025NIH's project files
U01HG006379EHR-based Genomic Discovery and Implementation [Funded Extension]122,025NIH's project files
R01HL135109Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation112,025NIH's project files
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology102,025NIH's project files
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling102,025NIH's project files

Papers 8126

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42815839PubTator, text miningPubMed
42813533PubTator, text miningPubMed
42798645PubTator, text miningPubMed
42787793PubTator, text miningPubMed
42781677PubTator, text miningPubMed
42780784PubTator, text miningPubMed
42764720PubTator, text miningPubMed
42758283PubTator, text miningPubMed
42753271PubTator, text miningPubMed
42750665PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license