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Gene · 635

BHMT: betaine--homocysteine S-methyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BHMT: betaine--homocysteine S-methyltransferase. Genes, record 635. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/635

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Gene

Symbol
BHMT
HGNC
Name
betaine--homocysteine S-methyltransferase
HGNC
NCBI Gene ID
635
NCBI Gene
HGNC ID
HGNC:1047
HGNC
Ensembl
ENSG00000145692
NCBI Gene
Aliases
BHMT1, HEL-S-61p
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q93088Betaine--homocysteine S-methyltransferase 14064Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438976Q93088Espacenet
EP 4650780 A22025-11-192902Q93088Espacenet
EP 4641201 A22025-10-292465Q93088Espacenet
JP 2025517969 A2025-06-122465Q93088Espacenet
JP 2025517970 A2025-06-122902Q93088Espacenet
JP 2025062604 A2025-04-149051Q93088Espacenet
US 11446398 B22022-09-209051Q93088Espacenet
JP 2022524081 A2022-04-27112022Q93088Espacenet
US 11078247 B22021-08-031152Q93088Espacenet
EP 3609522 A22020-02-19161Q93088Espacenet

1 to 10 of 19

See all 19 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BETAINECHEMBL95889Betaine-homocysteine S-methyltransferase substrateSUBSTRATE

Source ChEMBL

Trials14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07276204BETAINEPHASE2ClinicalTrials.gov
NCT06308367BETAINEPHASE2ClinicalTrials.gov
NCT05342272BETAINEPHASE3ClinicalTrials.gov
NCT02404337BETAINEPHASE2ClinicalTrials.gov
NCT02122211BETAINEPHASE1ClinicalTrials.gov
NCT01950039BETAINEPHASE22021-04-20ClinicalTrials.gov
NCT01838941BETAINEPHASE32016-06-28ClinicalTrials.gov
NCT01371357BETAINEPHASE3ClinicalTrials.gov
NCT00882193BETAINEEARLY_PHASE1ClinicalTrials.gov
NCT00586911BETAINEPHASE2ClinicalTrials.gov

1 to 10 of 14

See all 14 trials

NIH grants849

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBHMT papersNewest fiscal year
P30DK056350Nutrition Obesity Research Center (NORC)182025
P30ES010126UNC Center for Environmental Health and Susceptibility142025
P30ES009089Center for Environmental Health in Northern Manhattan102025
P50AA011999Southern California Research Center for ALPD and Cirrhosis72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
ZIAHG000167The contribution folate and vitamin B12 genes to disease.42025
P30CA046934University of Colorado Cancer Center Support Grant32025
P50AA022538Center for Alcohol Research in Epigenetics32025

1 to 10 of 849Source NIH's project files

See all 849 nih grants

Papers1,275

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Trimethylamine N-oxide and Homocysteine in Kidney Function and Disease: Distinct Metabolic Origins, Shared Renal Determinants and Pathophysiological Pathways.Int J Mol Sci202642737421PubTator, text miningPubMed
Biochemical characterization of a homocysteine S-methyltransferase from Leuconostoc suionicum.J Biochem202642720554PubTator, text miningPubMed
Educational attainment and diabetes risk: triangulation evidence from UK Biobank prospective cohort, NHANES 2011-2018, and cross-trait genomics analyses.Front Endocrinol (Lausanne)202642434303PubTator, text miningPubMed
Choline-dependent methionine metabolism supports leukemia progression.Commun Biol202642393218PubTator, text miningPubMed
(6S)-5-Methyltetrahydrofolate Dicholine Salt Modulates Methyl-Donor Metabolites and Repetitive-Element DNA Methylation in HepaRG Cells.J Diet Suppl202642217246PubTator, text miningPubMed
Optimal replacement value of betaine for dietary methionine in broilers from 22 to 42 days of age.J Anim Sci202642104195PubTator, text miningPubMed
Brain B Vitamin Status and One-Carbon Metabolism Gene Polymorphisms are Associated with Cognitive Impairment in Alzheimer's and Parkinson's Disease.bioRxiv202642079267PubTator, text miningPubMed
BHMT Protects Against Diabetic Cataracts by Reducing Homocysteine and Counteracting Endoplasmic Reticulum Stress in Lens Epithelial Cells.Appl Biochem Biotechnol202641910712PubTator, text miningPubMed
Targeting metabolic dysregulation in HCC: Development and validation of a dual-biomarker diagnostic model integrating ADH1C and BHMT.Clin Res Hepatol Gastroenterol202641895659PubTator, text miningPubMed
Mechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum.Nat Commun202641786780PubTator, text miningPubMed

1 to 10 of 1,275

See all 1,275 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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