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CX3CL1: C-X3-C motif chemokine ligand 1

1 protein, 176 patents, 1 drug, 7 trials, 4,985 NIH grants and 8,627 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCX3CL1HGNC
NameC-X3-C motif chemokine ligand 1HGNC
NCBI Gene ID6376NCBI Gene
HGNC IDHGNC:10647HGNC
EnsemblENSG00000006210NCBI Gene
AliasesABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactinNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P78423Fractalkine39710Ensembl, GeneID, HGNCUniProt

Patents 176

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120675 A2026-07-22764P78423Espacenet
EP 4705273 A22026-03-11244P78423Espacenet
JP 2026004568 A2026-01-1441072P78423Espacenet
EP 4650780 A22025-11-1924P78423Espacenet
JP 2025147176 A2025-10-063787P78423Espacenet
JP 2025147176 A2025-10-0616692P78423Espacenet
JP 2025529142 A2025-09-041156P78423Espacenet
JP 2025529142 A2025-09-046069P78423Espacenet
US 12371689 B22025-07-291156P78423Espacenet
US 12371689 B22025-07-296069P78423Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
QUETMOLIMABCHEMBL4297942Fractalkine inhibitorINHIBITORChEMBL

Trials 7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03733314QUETMOLIMABPHASE22025-04-02ClinicalTrials.gov
NCT03092765QUETMOLIMABPHASE2ClinicalTrials.gov
NCT02960490QUETMOLIMABPHASE22021-08-23ClinicalTrials.gov
NCT02960438QUETMOLIMABPHASE22021-06-21ClinicalTrials.gov
NCT02249078QUETMOLIMABPHASE1ClinicalTrials.gov
NCT02196558QUETMOLIMABPHASE1/PHASE22020-08-13ClinicalTrials.gov
NCT02039063QUETMOLIMABPHASE1/PHASE22023-01-30ClinicalTrials.gov

NIH grants 4985

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant162,025NIH's project files
P30CA016672Cancer Center Support Grant162,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award122,025NIH's project files
ZIAAI000615Molecular Analysis Of Leukocyte Activation By Chemoattractants122,025NIH's project files
P30AI036214San Diego Center for AIDS Research (SD CFAR)102,025NIH's project files
P30AI036219Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)92,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research82,025NIH's project files
P30CA023108Cancer Center Support Grant82,025NIH's project files
P30DK019525University of Pennsylvania Diabetes Research Center82,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology82,025NIH's project files

Papers 8627

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42808228PubTator, text miningPubMed
42807254PubTator, text miningPubMed
42801162PubTator, text miningPubMed
42795418PubTator, text miningPubMed
42791438PubTator, text miningPubMed
42771561PubTator, text miningPubMed
42768014PubTator, text miningPubMed
42755124PubTator, text miningPubMed
42732855PubTator, text miningPubMed
42725064PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license