Gene · 638
BIK: BCL2 interacting killer
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BIK: BCL2 interacting killer. Genes, record 638. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/638
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13323 | Bcl-2-interacting killer | 160 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents73
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025529142 A | 2025-09-04 | 584 | Q13323 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 584 | Q13323 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 8772 | Q13323 | Espacenet |
| JP 2025509333 A | 2025-04-11 | 42 | Q13323 | Espacenet |
| EP 4490205 A2 | 2025-01-15 | 42 | Q13323 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5037 | Q13323 | Espacenet |
| JP 2023532273 A | 2023-07-27 | 42 | Q13323 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1463 | Q13323 | Espacenet |
| US 11656230 B2 | 2023-05-23 | 9 | Q13323 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 8772 | Q13323 | Espacenet |
1 to 10 of 73
See all 73 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,453
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BIK papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 26 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 8 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 8 | 2025 |
| T32CA009686 | Training Grant In Tumor Biology | 8 | 2025 |
| P01CA066996 | Development of Novel Therapeutic Strategies in Human Leukemias | 7 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 7 | 2025 |
| P50CA097190 | Head and Neck Cancer SPORE | 7 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 6 | 2025 |
1 to 10 of 1,453Source NIH's project files
See all 1,453 nih grantsPapers2,521
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A parsimonious three-gene mitochondrial classifier from frontal cortex for Alzheimer's disease: Nested cross-validation and multicenter external validation. | J Alzheimers Dis | 2026 | 42742534 | PubTator, text mining | PubMed |
| DNAJB12/14 redox switching directs chaperone- and Bax/Bak-dependent ER protein reflux. | Redox Biol | 2026 | 42508238 | PubTator, text mining | PubMed |
| Exploring Omeprazole Effect on Pro-apoptotic Factors in Colorectal Cancer Treatment: Insights from In Silico Studies and Antiproliferative Assessment on HT29 Cells. | Curr Comput Aided Drug Des | 2026 | 42483915 | PubTator, text mining | PubMed |
| LDHA, BIK, and CNIH4 Are Diagnostic Markers of Endoplasmic Reticulum Stress in Lung Cancer Comorbid With Sepsis: Integrating Machine Learning and Single-Cell Analysis of Immune Signaling. | Mediators Inflamm | 2026 | 42434863 | PubTator, text mining | PubMed |
| Apoptotic Signaling Across Breast Cancer Subtypes and Cryoablation-Induced Tissue Injury. | Int J Mol Sci | 2026 | 42352901 | PubTator, text mining | PubMed |
| Comprehensive Analysis of Genomic and Phenomic Data Reveals Context-Dependent Function of A20 (TNFAIP3) in Renal Cell Carcinoma. | Cancers (Basel) | 2026 | 42279358 | PubTator, text mining | PubMed |
| Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications. | Signal Transduct Target Ther | 2026 | 41881983 | PubTator, text mining | PubMed |
| SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells. | PLoS Pathog | 2026 | 41855156 | PubTator, text mining | PubMed |
| Beyond blacklists: a critical assessment of exclusion set generation strategies and alternative approaches. | Bioinformatics | 2026 | 41826793 | PubTator, text mining | PubMed |
| Enhancing cancer killing and natural killer cell persistence by targeting NOXA, a predictor of poor patient survival. | Mol Ther Oncol | 2026 | 41783357 | PubTator, text mining | PubMed |
1 to 10 of 2,521
See all 2,521 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/638
GET https://conductscience.org/api/genes/v1/638/patents?page=2