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Gene · 638

BIK: BCL2 interacting killer

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BIK: BCL2 interacting killer. Genes, record 638. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/638

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Gene

Symbol
BIK
HGNC
Name
BCL2 interacting killer
HGNC
NCBI Gene ID
638
NCBI Gene
HGNC ID
HGNC:1051
HGNC
Ensembl
ENSG00000100290
NCBI Gene
Aliases
BIP1, BP4, NBK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13323Bcl-2-interacting killer1600Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-04584Q13323Espacenet
US 12371689 B22025-07-29584Q13323Espacenet
JP 2025062604 A2025-04-148772Q13323Espacenet
JP 2025509333 A2025-04-1142Q13323Espacenet
EP 4490205 A22025-01-1542Q13323Espacenet
JP 2024123008 A2024-09-105037Q13323Espacenet
JP 2023532273 A2023-07-2742Q13323Espacenet
US 11708396 B22023-07-251463Q13323Espacenet
US 11656230 B22023-05-239Q13323Espacenet
US 11446398 B22022-09-208772Q13323Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,453

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBIK papersNewest fiscal year
P30CA016672Cancer Center Support Grant262025
P30CA008748Cancer Center Support Grant122025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant82025
P30CA016059Massey Cancer Center - Cancer Center Support Grant82025
T32CA009686Training Grant In Tumor Biology82025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias72025
P30CA047904Cancer Center Support Grant72025
P50CA097190Head and Neck Cancer SPORE72025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology62025

1 to 10 of 1,453Source NIH's project files

See all 1,453 nih grants

Papers2,521

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A parsimonious three-gene mitochondrial classifier from frontal cortex for Alzheimer's disease: Nested cross-validation and multicenter external validation.J Alzheimers Dis202642742534PubTator, text miningPubMed
DNAJB12/14 redox switching directs chaperone- and Bax/Bak-dependent ER protein reflux.Redox Biol202642508238PubTator, text miningPubMed
Exploring Omeprazole Effect on Pro-apoptotic Factors in Colorectal Cancer Treatment: Insights from In Silico Studies and Antiproliferative Assessment on HT29 Cells.Curr Comput Aided Drug Des202642483915PubTator, text miningPubMed
LDHA, BIK, and CNIH4 Are Diagnostic Markers of Endoplasmic Reticulum Stress in Lung Cancer Comorbid With Sepsis: Integrating Machine Learning and Single-Cell Analysis of Immune Signaling.Mediators Inflamm202642434863PubTator, text miningPubMed
Apoptotic Signaling Across Breast Cancer Subtypes and Cryoablation-Induced Tissue Injury.Int J Mol Sci202642352901PubTator, text miningPubMed
Comprehensive Analysis of Genomic and Phenomic Data Reveals Context-Dependent Function of A20 (TNFAIP3) in Renal Cell Carcinoma.Cancers (Basel)202642279358PubTator, text miningPubMed
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.Signal Transduct Target Ther202641881983PubTator, text miningPubMed
SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells.PLoS Pathog202641855156PubTator, text miningPubMed
Beyond blacklists: a critical assessment of exclusion set generation strategies and alternative approaches.Bioinformatics202641826793PubTator, text miningPubMed
Enhancing cancer killing and natural killer cell persistence by targeting NOXA, a predictor of poor patient survival.Mol Ther Oncol202641783357PubTator, text miningPubMed

1 to 10 of 2,521

See all 2,521 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/638

GET https://conductscience.org/api/genes/v1/638/patents?page=2