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Gene · 6385

SDC4: syndecan 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SDC4: syndecan 4. Genes, record 6385. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6385

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Gene

Symbol
SDC4
HGNC
Name
syndecan 4
HGNC
NCBI Gene ID
6385
NCBI Gene
HGNC ID
HGNC:10661
HGNC
Ensembl
ENSG00000124145
NCBI Gene
Aliases
SYND4, amphiglycan, ryudocan
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P31431Syndecan-41985Ensembl, GeneID, HGNC

Source UniProt

Patents75

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026209808 A12026-10-087P31431Espacenet
JP 2026090543 A2026-06-02756P31431Espacenet
JP 2026004568 A2026-01-1466158P31431Espacenet
EP 4650780 A22025-11-199161P31431Espacenet
WO 2025228986 A12025-11-0614P31431Espacenet
EP 4644537 A12025-11-0514P31431Espacenet
EP 4641202 A22025-10-29525P31431Espacenet
EP 4641203 A22025-10-29271P31431Espacenet
JP 2025517967 A2025-06-12271P31431Espacenet
JP 2025517970 A2025-06-129161P31431Espacenet

1 to 10 of 75

See all 75 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
REPOTRECTINIBCHEMBL4298138ROS1-SDC4 inhibitorINHIBITOR

Source ChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07599007REPOTRECTINIBClinicalTrials.gov
NCT06552234REPOTRECTINIBPHASE2ClinicalTrials.gov
NCT06408168REPOTRECTINIBPHASE2ClinicalTrials.gov
NCT06315010REPOTRECTINIBPHASE2ClinicalTrials.gov
NCT06140836REPOTRECTINIBPHASE3ClinicalTrials.gov
NCT05004116REPOTRECTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT04772235REPOTRECTINIBPHASE1ClinicalTrials.gov
NCT04094610REPOTRECTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT03093116REPOTRECTINIBPHASE1/PHASE2ClinicalTrials.gov

NIH grants1,634

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSDC4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant192025
P30CA046934University of Colorado Cancer Center Support Grant92025
P30EY016665Core Grant for Vision Research92025
R01CA164273Overcoming Resistance Mechanisms to Anaplastic Lymphoma Kinase Inhibitors72025
K12CA086913Paul Calabresi Award in Clinical Oncology Research62025
P30CA016672Cancer Center Support Grant52025
P30DK056336UAB Nutrition Obesity Research Center (NORC)52025
P30EY010572Ophthalmology Core Facility52025
P30CA014520UW Comprehensive Cancer Center Support42025
P30CA068485Cancer Center Support Grant42025

1 to 10 of 1,634Source NIH's project files

See all 1,634 nih grants

Papers3,062

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Glycocalyx and Metabolomic Profiles After Trauma Across Age and Frailty Groups: A Pilot Study.J Surg Res202642785046PubTator, text miningPubMed
Exploring the impact of syndecans in prostate cancer: Stage-specific roles and therapeutic implications.Eur J Cell Biol202642721521PubTator, text miningPubMed
Myofibroblastic CAF and Malignant Ductal Cell Crosstalk Drives Epithelial-Mesenchymal Transition and Progression in Pancreatic Ductal Adenocarcinoma via THBS2-SDC/Integrin Axes.Int J Mol Sci202642589604PubTator, text miningPubMed
Mechanosensors Collaborate to Regulate DNA Damage Repair in Hepatocellular Carcinoma.Cancer Res202642525956PubTator, text miningPubMed
Single-cell and spatial transcriptomics uncover a THBS2⁺ CAF-KRT17⁺ malignant cell axis drives progression and immunotherapy resistance in pancreatic cancer.Transl Oncol202642520475PubTator, text miningPubMed
ANGPTL4 in gestational diabetes: a diagnostic biomarker linked to placental senescence.Funct Integr Genomics202642487020PubTator, text miningPubMed
Analytical and clinical validation of a novel proximity extension assay-based plasma biomarker panel in a cohort of prevalent neurodegenerative dementias.Alzheimers Res Ther202642436533PubTator, text miningPubMed
Deep Proteomic Analysis With Machine Learning Identifies Aqueous Humor Biomarkers of ADAMTSL4-associated Congenital Ectopia Lentis.Invest Ophthalmol Vis Sci202642423409PubTator, text miningPubMed
Heparan Sulfate Proteoglycans in Immunity.Proteoglycan Res202642383138PubTator, text miningPubMed
Association of circulating biomarkers of glycocalyx injury, sirtuin 1, and NFκB p65 in individuals with type 2 diabetes and concurrent arterial hypertension.Microvasc Res202642320824PubTator, text miningPubMed

1 to 10 of 3,062

See all 3,062 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6385

GET https://conductscience.org/api/genes/v1/6385/patents?page=2