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CXCL12: C-X-C motif chemokine ligand 12

1 protein, 231 patents, 1 drug, 4 trials, 12,972 NIH grants and 31,740 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCXCL12HGNC
NameC-X-C motif chemokine ligand 12HGNC
NCBI Gene ID6387NCBI Gene
HGNC IDHGNC:10672HGNC
EnsemblENSG00000107562NCBI Gene
AliasesIRH, PBSF, SCYB12, SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, TLSF, TLSF-a, TLSF-b, TPAR1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P48061Stromal cell-derived factor 19334Ensembl, GeneID, HGNCUniProt

Patents 231

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120675 A2026-07-22756P48061Espacenet
JP 2026094382 A2026-06-0929P48061Espacenet
EP 4705273 A22026-03-11260P48061Espacenet
EP 4650780 A22025-11-199464P48061Espacenet
WO 2025219552 A12025-10-2315P48061Espacenet
JP 2025147176 A2025-10-063801P48061Espacenet
JP 2025147176 A2025-10-0616697P48061Espacenet
JP 2025529142 A2025-09-046074P48061Espacenet
US 12371689 B22025-07-296074P48061Espacenet
US 12365876 B22025-07-222P48061Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
OLAPTESED PEGOLCHEMBL4594485Stromal cell-derived factor 1 inhibitorINHIBITORChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04121455OLAPTESED PEGOLPHASE1/PHASE2ClinicalTrials.gov
NCT03168139OLAPTESED PEGOLPHASE1/PHASE2ClinicalTrials.gov
NCT01521533OLAPTESED PEGOLPHASE2ClinicalTrials.gov
NCT01486797OLAPTESED PEGOLPHASE2ClinicalTrials.gov

NIH grants 12972

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1562,025NIH's project files
P30CA008748Cancer Center Support Grant832,025NIH's project files
P30CA006973Regional Oncology Research Center492,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award312,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028272,025NIH's project files
P30CA068485Cancer Center Support Grant272,025NIH's project files
P30CA047904Cancer Center Support Grant262,025NIH's project files
ZIAAI000615Molecular Analysis Of Leukocyte Activation By Chemoattractants262,025NIH's project files
R01EY012601Hematopoietic cell mobilization from distinct bone marrow compartments following retinal injury252,025NIH's project files
P30CA016058Cancer Center Support Grant242,025NIH's project files

Papers 31740

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816584PubTator, text miningPubMed
42812889PubTator, text miningPubMed
42811017PubTator, text miningPubMed
42801211PubTator, text miningPubMed
42793037PubTator, text miningPubMed
42792164PubTator, text miningPubMed
42789016PubTator, text miningPubMed
42788441PubTator, text miningPubMed
42786580PubTator, text miningPubMed
42781331PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license