Gene · 63895
PIEZO2: piezo type mechanosensitive ion channel component 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PIEZO2: piezo type mechanosensitive ion channel component 2. Genes, record 63895. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/63895
On this page
Gene
- Aliases
- C18orf30, C18orf58, DA3, DA5, DAIPT, FAM38B, FAM38B2, FLJ23144, FLJ23403, FLJ34907, HsT748, HsT771, MWKS
- NCBI Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H5I5 | Piezo-type mechanosensitive ion channel component 2 | 2,752 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents20
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58066 | Q9H5I5 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 17042 | Q9H5I5 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3469 | Q9H5I5 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3469 | Q9H5I5 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 17042 | Q9H5I5 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33409 | Q9H5I5 | Espacenet |
| US 12178902 B1 | 2024-12-31 | 4 | Q9H5I5 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33409 | Q9H5I5 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 33409 | Q9H5I5 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 63720 | Q9H5I5 | Espacenet |
1 to 10 of 20
See all 20 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants902
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PIEZO2 papers | Newest fiscal year |
|---|---|---|---|
| ZIAAT000028 | Studies on the molecular, cells, and circuit that underlie somatosensation and pain | 14 | 2025 |
| R35NS105067 | Mechanisms of force sensing in the nervous system | 10 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 8 | 2025 |
| R01NS070711 | Nociceptive Mechanisms Underlying Sickle Cell Pain | 8 | 2025 |
| R01DK052766 | Mechanotransduction in Intestinal Smooth Muscle Cells | 7 | 2025 |
| R37NS108278 | Pain Mechanisms in Fabry Disease | 6 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 5 | 2025 |
| R01DE023090 | Cellular and Ion Channel Mechanisms Underlying the Sense of Light Touch in Mammals | 5 | 2025 |
| R01NS097547 | Mechanism of touch sensitivity in rapidly-adapting mechanosensory corpuscles | 5 | 2025 |
| ZIANS003129 | Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies | 5 | 2025 |
1 to 10 of 902Source NIH's project files
See all 902 nih grantsPapers1,323
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Energy-responsive multi-catalytic nanogenerator hydrogels synergistically enhance diabetic tendon-to-bone healing via the ages/RAGE/PIEZO2 axis. | Biomaterials | 2027 | 42442283 | PubTator, text mining | PubMed |
| Mechanosensitive ion channels in intestinal homeostasis and disease. | eGastroenterology | 2026 | 42824911 | PubTator, text mining | PubMed |
| Loss of novel mechanosensitive ion channel TMEM63A impairs osteogenic differentiation and proliferation via disruption of cellular mechanotransduction. | Mechanobiol Med | 2026 | 42787916 | PubTator, text mining | PubMed |
| Vagal PIEZO2-Positive Neurons Mediate Blood Volume Sensing and Circulatory Homeostasis Regulation. | Neurosci Bull | 2026 | 42730848 | PubTator, text mining | PubMed |
| Mechanosensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology. | Cardiovasc Res | 2026 | 42687771 | PubTator, text mining | PubMed |
| Piezo1 and Piezo2 in neurological disorders: From mechanotransduction to therapeutic potential. | Curr Opin Pharmacol | 2026 | 42679748 | PubTator, text mining | PubMed |
| Corticosteroid-induced alterations in cytoskeletal organization and mechanosensing of osteoarthritic synoviocytes. | Eur J Cell Biol | 2026 | 42679564 | PubTator, text mining | PubMed |
| A Propeller with a Flexible Twist: A Computational Analysis of Intrinsically Disordered Regions in PIEZO Gating and PIEZO-Associated Channelopathies. | Proteomes | 2026 | 42647377 | PubTator, text mining | PubMed |
| Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neurons. | bioRxiv | 2026 | 42619858 | PubTator, text mining | PubMed |
| Decoding osteosarcoma mechanobiology: PIEZO channels in tumor progression, immune remodeling, and pain. | Cancer Metastasis Rev | 2026 | 42616189 | PubTator, text mining | PubMed |
1 to 10 of 1,323
See all 1,323 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/63895
GET https://conductscience.org/api/genes/v1/63895/patents