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Gene · 63895

PIEZO2: piezo type mechanosensitive ion channel component 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIEZO2: piezo type mechanosensitive ion channel component 2. Genes, record 63895. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/63895

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Gene

Symbol
PIEZO2
HGNC
Name
piezo type mechanosensitive ion channel component 2
HGNC
NCBI Gene ID
63895
NCBI Gene
HGNC ID
HGNC:26270
HGNC
Ensembl
ENSG00000154864
NCBI Gene
Aliases
C18orf30, C18orf58, DA3, DA5, DAIPT, FAM38B, FAM38B2, FLJ23144, FLJ23403, FLJ34907, HsT748, HsT771, MWKS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H5I5Piezo-type mechanosensitive ion channel component 22,7522Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458066Q9H5I5Espacenet
EP 4641201 A22025-10-2917042Q9H5I5Espacenet
JP 2025529142 A2025-09-043469Q9H5I5Espacenet
US 12371689 B22025-07-293469Q9H5I5Espacenet
JP 2025517969 A2025-06-1217042Q9H5I5Espacenet
JP 2025032204 A2025-03-1133409Q9H5I5Espacenet
US 12178902 B12024-12-314Q9H5I5Espacenet
EP 4461818 A22024-11-1333409Q9H5I5Espacenet
JP 2023058610 A2023-04-2533409Q9H5I5Espacenet
US 11446398 B22022-09-2063720Q9H5I5Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants902

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIEZO2 papersNewest fiscal year
ZIAAT000028Studies on the molecular, cells, and circuit that underlie somatosensation and pain142025
R35NS105067Mechanisms of force sensing in the nervous system102025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology82025
R01NS070711Nociceptive Mechanisms Underlying Sickle Cell Pain82025
R01DK052766Mechanotransduction in Intestinal Smooth Muscle Cells72025
R37NS108278Pain Mechanisms in Fabry Disease62025
P40OD010440Caenorhabditis Genetics Center52025
R01DE023090Cellular and Ion Channel Mechanisms Underlying the Sense of Light Touch in Mammals52025
R01NS097547Mechanism of touch sensitivity in rapidly-adapting mechanosensory corpuscles52025
ZIANS003129Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies52025

1 to 10 of 902Source NIH's project files

See all 902 nih grants

Papers1,323

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Energy-responsive multi-catalytic nanogenerator hydrogels synergistically enhance diabetic tendon-to-bone healing via the ages/RAGE/PIEZO2 axis.Biomaterials202742442283PubTator, text miningPubMed
Mechanosensitive ion channels in intestinal homeostasis and disease.eGastroenterology202642824911PubTator, text miningPubMed
Loss of novel mechanosensitive ion channel TMEM63A impairs osteogenic differentiation and proliferation via disruption of cellular mechanotransduction.Mechanobiol Med202642787916PubTator, text miningPubMed
Vagal PIEZO2-Positive Neurons Mediate Blood Volume Sensing and Circulatory Homeostasis Regulation.Neurosci Bull202642730848PubTator, text miningPubMed
Mechanosensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology.Cardiovasc Res202642687771PubTator, text miningPubMed
Piezo1 and Piezo2 in neurological disorders: From mechanotransduction to therapeutic potential.Curr Opin Pharmacol202642679748PubTator, text miningPubMed
Corticosteroid-induced alterations in cytoskeletal organization and mechanosensing of osteoarthritic synoviocytes.Eur J Cell Biol202642679564PubTator, text miningPubMed
A Propeller with a Flexible Twist: A Computational Analysis of Intrinsically Disordered Regions in PIEZO Gating and PIEZO-Associated Channelopathies.Proteomes202642647377PubTator, text miningPubMed
Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neurons.bioRxiv202642619858PubTator, text miningPubMed
Decoding osteosarcoma mechanobiology: PIEZO channels in tumor progression, immune remodeling, and pain.Cancer Metastasis Rev202642616189PubTator, text miningPubMed

1 to 10 of 1,323

See all 1,323 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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