ConductScience.org, home

Gene · 6392

SDHD: succinate dehydrogenase complex subunit D

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. SDHD: succinate dehydrogenase complex subunit D. Genes, record 6392. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6392

On this page

Gene

Symbol
SDHD
HGNC
Name
succinate dehydrogenase complex subunit D
HGNC
NCBI Gene ID
6392
NCBI Gene
HGNC ID
HGNC:10683
HGNC
Ensembl
ENSG00000204370
NCBI Gene
Aliases
CBT1, CII-4, CWS3, MC2DN3, PGL, PGL1, PPGL1, QPs3, SDH4, cybS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14521Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial1592Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465708O14521Espacenet
EP 4650780 A22025-11-199649O14521Espacenet
JP 2025147176 A2025-10-0611757O14521Espacenet
JP 2025529142 A2025-09-043863O14521Espacenet
JP 2025529142 A2025-09-047646O14521Espacenet
US 12371689 B22025-07-293863O14521Espacenet
US 12371689 B22025-07-297646O14521Espacenet
JP 2025517970 A2025-06-129649O14521Espacenet
JP 2025028160 A2025-02-2811757O14521Espacenet
KR 1020250010750 A2025-01-2111757O14521Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,119

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSDHD papersNewest fiscal year
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer202025
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene202025
P30CA008748Cancer Center Support Grant192025
P30CA016672Cancer Center Support Grant192025
ZIDBC011089Clinical Nursing and Data Management Core182025
P30CA016058Cancer Center Support Grant112025
ZIABC011043Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene112025
ZIESC000853Translational Surgical Pathology112025
P30CA006927Comprehensive Cancer Center Program at Fox Chase102025
P30CA054174Mays Cancer Center at UT Health SA92025

1 to 10 of 1,119Source NIH's project files

See all 1,119 nih grants

Papers2,836

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Succinate dehydrogenase (SDHB, SDHC, and SDHD) gene variants significantly modify clinical outcomes in paraganglioma-pheochromocytoma but have a limited impact on head and neck paraganglioma.Genet Med202642813377PubTator, text miningPubMed
Calcitonin-negative 'MTC-like' thyroid paraganglioma revealing an SDHD-related hereditary paraganglioma syndrome: functional confirmation of a non-canonical splice-site variant.Eur Thyroid J202642804417PubTator, text miningPubMed
Succinate Dehydrogenase Subunit D as a Redox-Responsive Mitochondrial Component Linked to Aquaporin-Associated Hydrogen Peroxide Signaling in Glioblastoma Cells.Antioxidants (Basel)202642792164PubTator, text miningPubMed
Investigating the clinical utility of plasma succinate with insights from an Sdhb-deficient murine model.Endocr Relat Cancer202642758527PubTator, text miningPubMed
N-Acetyl-L-Cysteine Promotes Porcine Oocyte In Vitro Maturation and Subsequent Embryonic Development by Regulating Oxidative Stress.Biology (Basel)202642737891PubTator, text miningPubMed
Somatic-only SDHD variant with tumor-specific loss of heterozygosity in metastatic carotid body tumor: a case report with review of literature.Endocr J202642732958PubTator, text miningPubMed
Complex landscape of somatic copy number alterations in head and neck paragangliomas.Front Endocrinol (Lausanne)202642666236PubTator, text miningPubMed
Virulence Profiles and Fungicide-Target-Gene Variability in Puccinia graminis f. sp. tritici Populations from Russian Regions.J Fungi (Basel)202642646131PubTator, text miningPubMed
Genetic testing in pituitary adenomas: a Pituitary Society International Consensus Statement.Nat Rev Endocrinol202642642458PubTator, text miningPubMed
Genetic, cellular, and environmental factors influencing tumourigenesis in carriers of succinate dehydrogenase germline mutations.Endocr Relat Cancer202642626917PubTator, text miningPubMed

1 to 10 of 2,836

See all 2,836 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6392

GET https://conductscience.org/api/genes/v1/6392/patents?page=2