Gene · 6392
SDHD: succinate dehydrogenase complex subunit D
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SDHD: succinate dehydrogenase complex subunit D. Genes, record 6392. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6392
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14521 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 159 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65708 | O14521 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9649 | O14521 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 11757 | O14521 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3863 | O14521 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7646 | O14521 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3863 | O14521 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7646 | O14521 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9649 | O14521 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 11757 | O14521 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 11757 | O14521 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,119
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SDHD papers | Newest fiscal year |
|---|---|---|---|
| ZIABC011028 | Clinical Studies of the Molecular Genetic Basis of Kidney Cancer | 20 | 2025 |
| ZIABC011038 | Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene | 20 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 19 | 2025 |
| ZIDBC011089 | Clinical Nursing and Data Management Core | 18 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 11 | 2025 |
| ZIABC011043 | Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene | 11 | 2025 |
| ZIESC000853 | Translational Surgical Pathology | 11 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 10 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 9 | 2025 |
1 to 10 of 1,119Source NIH's project files
See all 1,119 nih grantsPapers2,836
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Succinate dehydrogenase (SDHB, SDHC, and SDHD) gene variants significantly modify clinical outcomes in paraganglioma-pheochromocytoma but have a limited impact on head and neck paraganglioma. | Genet Med | 2026 | 42813377 | PubTator, text mining | PubMed |
| Calcitonin-negative 'MTC-like' thyroid paraganglioma revealing an SDHD-related hereditary paraganglioma syndrome: functional confirmation of a non-canonical splice-site variant. | Eur Thyroid J | 2026 | 42804417 | PubTator, text mining | PubMed |
| Succinate Dehydrogenase Subunit D as a Redox-Responsive Mitochondrial Component Linked to Aquaporin-Associated Hydrogen Peroxide Signaling in Glioblastoma Cells. | Antioxidants (Basel) | 2026 | 42792164 | PubTator, text mining | PubMed |
| Investigating the clinical utility of plasma succinate with insights from an Sdhb-deficient murine model. | Endocr Relat Cancer | 2026 | 42758527 | PubTator, text mining | PubMed |
| N-Acetyl-L-Cysteine Promotes Porcine Oocyte In Vitro Maturation and Subsequent Embryonic Development by Regulating Oxidative Stress. | Biology (Basel) | 2026 | 42737891 | PubTator, text mining | PubMed |
| Somatic-only SDHD variant with tumor-specific loss of heterozygosity in metastatic carotid body tumor: a case report with review of literature. | Endocr J | 2026 | 42732958 | PubTator, text mining | PubMed |
| Complex landscape of somatic copy number alterations in head and neck paragangliomas. | Front Endocrinol (Lausanne) | 2026 | 42666236 | PubTator, text mining | PubMed |
| Virulence Profiles and Fungicide-Target-Gene Variability in Puccinia graminis f. sp. tritici Populations from Russian Regions. | J Fungi (Basel) | 2026 | 42646131 | PubTator, text mining | PubMed |
| Genetic testing in pituitary adenomas: a Pituitary Society International Consensus Statement. | Nat Rev Endocrinol | 2026 | 42642458 | PubTator, text mining | PubMed |
| Genetic, cellular, and environmental factors influencing tumourigenesis in carriers of succinate dehydrogenase germline mutations. | Endocr Relat Cancer | 2026 | 42626917 | PubTator, text mining | PubMed |
1 to 10 of 2,836
See all 2,836 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6392
GET https://conductscience.org/api/genes/v1/6392/patents?page=2