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Gene · 63976

PRDM16: PR/SET domain 16

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRDM16: PR/SET domain 16. Genes, record 63976. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/63976

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Gene

Symbol
PRDM16
HGNC
Name
PR/SET domain 16
HGNC
NCBI Gene ID
63976
NCBI Gene
HGNC ID
HGNC:14000
HGNC
Ensembl
ENSG00000142611
NCBI Gene
Aliases
CMD1LL, KIAA1675, KMT8F, LVNC8, MEL1, MGC166915, PFM13
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HAZ2Histone-lysine N-methyltransferase PRDM161,2762Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458862Q9HAZ2Espacenet
EP 4640849 A22025-10-29340Q9HAZ2Espacenet
EP 4641201 A22025-10-292332Q9HAZ2Espacenet
JP 2025147176 A2025-10-0615529Q9HAZ2Espacenet
JP 2025519096 A2025-06-24340Q9HAZ2Espacenet
JP 2025517969 A2025-06-122332Q9HAZ2Espacenet
JP 2025028160 A2025-02-2815529Q9HAZ2Espacenet
KR 1020250010750 A2025-01-2115529Q9HAZ2Espacenet
JP 2024109657 A2024-08-1415368Q9HAZ2Espacenet
US 11446398 B22022-09-2066110Q9HAZ2Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,992

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRDM16 papersNewest fiscal year
R01DK097441Molecular mechanisms of UCP1-independent pathways in metabolic health212025
P30DK036836Diabetes Research Center152025
P30DK020572Michigan Diabetes Research Center (MDRC)122025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)112025
R01DK082659Developmental genes, miRNAs and adipose tissue102025
P30CA008748Cancer Center Support Grant92025
P30DK026687New York Obesity Research Center92025
R01HD067449Maternal obesity, AMPK and Developmental Programming92025
P30DK063491Diabetes Research Center (DRC)82025
ZIADK075112The Molecular, Cellular, and Genetic characterization of Human Adipose Tissue and its Role in Metabolism82025

1 to 10 of 1,992Source NIH's project files

See all 1,992 nih grants

Papers2,448

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ETS-2 deficiency impairs brown adipose tissue function through Prdm16 repression.Metabolism202642800535PubTator, text miningPubMed
PRDM16 as a Multifaceted Pharmacological Target in Kidney Diseases: From Epigenetic Mechanisms to Therapeutic Strategies.Pharmaceuticals (Basel)202642797514PubTator, text miningPubMed
Concurrent RUNX1::MECOM and RUNX1::PRDM16 Fusions from a Novel Genomic Breakpoint: First Report of a Dual-Fusion Mechanism in Acute Myeloid Leukemia.Onco Targets Ther202642764945PubTator, text miningPubMed
An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy.Circulation202642708185PubTator, text miningPubMed
Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults.Environ Epigenet202642698993PubTator, text miningPubMed
Integrative functional bioinformatic analysis of NAD+-associated protein coding genes in adipose tissue (dys)function - evidence from targeted rodent transcriptomic studies.Front Endocrinol (Lausanne)202642553099PubTator, text miningPubMed
[Analysis of Genetic Characteristics and Clinical Efficacy in Pediatric Acute Myeloid Leukemia with NUP98∷KDM5A Fusion Gene Positive].Zhongguo Shi Yan Xue Ye Xue Za Zhi202642544647PubTator, text miningPubMed
Epigenetic Signature of the Metastable Epiallele VTRNA2-1: Adipose Dysfunction and Suboptimal Bariatric Outcomes.Obesity (Silver Spring)202642532515PubTator, text miningPubMed
Dieckol suppresses lipid accumulation and promotes thermogenic markers in 3T3-L1 adipocytes via ERK/p38 MAPK signaling.J Physiol Biochem202642530711PubTator, text miningPubMed
SPEN deficiency contributes to the development of orofacial clefts in humans and mice.Hum Mol Genet202642456047PubTator, text miningPubMed

1 to 10 of 2,448

See all 2,448 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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